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The Larynx in Leprosy

The Larynx in Leprosy Abstract Leprosy, the tragically dreaded, disfiguring, and mutilating disease, one of the oldest afflictions exclusively of mankind, is a contagious wasting constitutional disordercaused by the acid-fast Mycobacterium leprae, first described by Hansen in 1874 (Fig. 1). Both from the clinical and histopathological points of view, the manifestations of leprosy may be varied. The classification which divides the disease into three distinct types—the lepromatous (malignant or gravis), the tuberculoid (benign or mitis), and the indeterminate (undifferentiated) — is being used at our leprosarium, and we will adhere to it throughout this presentation. Histopathology In the lepromatous type the lesions are characterized by the presence of diffuse infiltration of the skin and nerves with vacuolated large mononuclear cells, or "lepra cells" (Figs. 2 and 3). In some of the viscera there may appear small groups of them as miliary lepromata. Bacilli are numerous within these cells, and in tissue spaces known as "globi." References 1. Sulphetrone is tetrasodium 4,4'-bis(γ-phenylpropylamino)-diphenylsulfone α,γ,α'γ'-tetrasulfonate. 2. Muir, E: Manual of Leprosy . Baltimore, Williams & Wilkins Company, 1948. 3. Chiyuto, S.: Leprosy Control Based on Transmission, Susceptibility and Pathogenesis , Month. Bull. Bur. Health Philippines 24:3-15, 1948. 4. Pinkerton, F. J.: Leprosy of the Upper Respiratory Tract , J.A. M. A. 111:1437-1443, 1938.Crossref 5. Elliott, D. C.: Leprosy, a Disease of Childhood , J. Pediat. 35:189-196, 1949.Crossref 6. Saunders, G. M.: Our Leprosy Problem , U. S. Nav. M. Bull. 44:54-64, 1945. 7. Andrews, G. C.: Diseases of the Skin , Philadelphia, W. B. Saunders Company, 1930. 8. Estella: Personal communication to the author. 9. Lie, H. P.: Tracheitis and Bronchitis Leprosa , Internat. J. Leprosy 4:281-288, 1936. 10. Evans, A.: A Specimen of Leprosy of the Larynx , J. Laryng. & Otol. 23:78-79, 1908. 11. Thomson, St. C.: A Case of Leprosy Showing Lesions in Soft Palate and Pharynx , J. Laryng. & Otol. 23:188, 1908. 12. Mostajo Barrera, J. J.: Estudio otorrinolaringologico de 114 enfermos de lepra , Rev. méd. peruana 22:605-619, 1951. 13. Sloan, N.: Tracheotomy in Leprosy , Internat. J. Leprosy 12:11-30, 1944. 14. Erickson, P. T., and Johansen, F. A.: Bone Changes in Leprosy Under Sulfone Therapy , Internat. J. Leprosy 16:147-156, 1948. 15. Sloan, N. R.: Effects of Sulfone Treatment on the Larynx in Leprosy , Internat. J. Leprosy 16:329-333, 1948. 16. Chover Madramany, P.: La Traqueotoimía y las sulfonas en la lepra , Fontilles 2:227-230, 1949 17. Internat. J. Leprosy 19:253-254, 1951. 18. Nemirowsky, S.: La Lepra en otorrinolaringologia , Rev. méd. Rosario 28:607-620, 1938 19. Internat. J. Leprosy 8:536, 1940. 20. Pinkerton, F. J.: Leprosy of the Ear, Nose and Throat: Observations on More Than 200 Cases in Hawaii , Arch. otolaryng. 16:469-487, 1932. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

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References (18)

Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1957.03830260024003
Publisher site
See Article on Publisher Site

Abstract

Abstract Leprosy, the tragically dreaded, disfiguring, and mutilating disease, one of the oldest afflictions exclusively of mankind, is a contagious wasting constitutional disordercaused by the acid-fast Mycobacterium leprae, first described by Hansen in 1874 (Fig. 1). Both from the clinical and histopathological points of view, the manifestations of leprosy may be varied. The classification which divides the disease into three distinct types—the lepromatous (malignant or gravis), the tuberculoid (benign or mitis), and the indeterminate (undifferentiated) — is being used at our leprosarium, and we will adhere to it throughout this presentation. Histopathology In the lepromatous type the lesions are characterized by the presence of diffuse infiltration of the skin and nerves with vacuolated large mononuclear cells, or "lepra cells" (Figs. 2 and 3). In some of the viscera there may appear small groups of them as miliary lepromata. Bacilli are numerous within these cells, and in tissue spaces known as "globi." References 1. Sulphetrone is tetrasodium 4,4'-bis(γ-phenylpropylamino)-diphenylsulfone α,γ,α'γ'-tetrasulfonate. 2. Muir, E: Manual of Leprosy . Baltimore, Williams & Wilkins Company, 1948. 3. Chiyuto, S.: Leprosy Control Based on Transmission, Susceptibility and Pathogenesis , Month. Bull. Bur. Health Philippines 24:3-15, 1948. 4. Pinkerton, F. J.: Leprosy of the Upper Respiratory Tract , J.A. M. A. 111:1437-1443, 1938.Crossref 5. Elliott, D. C.: Leprosy, a Disease of Childhood , J. Pediat. 35:189-196, 1949.Crossref 6. Saunders, G. M.: Our Leprosy Problem , U. S. Nav. M. Bull. 44:54-64, 1945. 7. Andrews, G. C.: Diseases of the Skin , Philadelphia, W. B. Saunders Company, 1930. 8. Estella: Personal communication to the author. 9. Lie, H. P.: Tracheitis and Bronchitis Leprosa , Internat. J. Leprosy 4:281-288, 1936. 10. Evans, A.: A Specimen of Leprosy of the Larynx , J. Laryng. & Otol. 23:78-79, 1908. 11. Thomson, St. C.: A Case of Leprosy Showing Lesions in Soft Palate and Pharynx , J. Laryng. & Otol. 23:188, 1908. 12. Mostajo Barrera, J. J.: Estudio otorrinolaringologico de 114 enfermos de lepra , Rev. méd. peruana 22:605-619, 1951. 13. Sloan, N.: Tracheotomy in Leprosy , Internat. J. Leprosy 12:11-30, 1944. 14. Erickson, P. T., and Johansen, F. A.: Bone Changes in Leprosy Under Sulfone Therapy , Internat. J. Leprosy 16:147-156, 1948. 15. Sloan, N. R.: Effects of Sulfone Treatment on the Larynx in Leprosy , Internat. J. Leprosy 16:329-333, 1948. 16. Chover Madramany, P.: La Traqueotoimía y las sulfonas en la lepra , Fontilles 2:227-230, 1949 17. Internat. J. Leprosy 19:253-254, 1951. 18. Nemirowsky, S.: La Lepra en otorrinolaringologia , Rev. méd. Rosario 28:607-620, 1938 19. Internat. J. Leprosy 8:536, 1940. 20. Pinkerton, F. J.: Leprosy of the Ear, Nose and Throat: Observations on More Than 200 Cases in Hawaii , Arch. otolaryng. 16:469-487, 1932.

Journal

A.M.A. Archives of OtolaryngologyAmerican Medical Association

Published: Aug 1, 1957

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