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Effect of Meclizine Hydrochloride (Bonamine) upon Vestibular Function: Observations with Notes on Its Value in Comparison with Cyclizine Hydrochloride (Marezine) and Dimenhydrinate (Dramamine)

Effect of Meclizine Hydrochloride (Bonamine) upon Vestibular Function: Observations with Notes on... Abstract Despite the many positive claims that have been made as to the efficacy of the various antivertiginous drugs now available, the search for a more effective compound with fewer side-reactions continues. Ideally, such medication, in addition to exhibiting a high degree of labyrinthine depression, should be relatively free of untoward sideeffects and possess an adequate duration of activity, thus eliminating the necessity for frequent administration. The preparation should, of course, be orally active and not interfere with the daily functions of the patient. Needless to say, such a compound has yet to be formulated. One of the newer drugs suggested for use in disturbances of labyrinthine function and associated disorders is meclizine hydrochloride (Parachloramine, Postafene). Chemically, it is the dihydrochloride of 1 -p -chlorobenzhydryl-4-m-methylbenzylpiperazine, having the accompanying structural formula. This compound has been found to possess antihistaminic and anticholinergic properties, either activity theoretically having some potential therapeutic value References 1. References 6 to 8. 2. References 9 and 10. 3. Eurard, E.: Prevention and Treatment of Air Sickness by a New Antihistaminic , Bruxelles univ. méd. 33:173 ( (Jan.) ) 1953. 4. Chinn, H. I.; Gammon, W. R., and Frantz, M. E.: Prevention of Airsickness Among Airborne Troops , J. Appl. Physiol. 5:599 ( (April) ) 1953. 5. Chinn, H. I.; Handford, S. W.; Smith, P. K.; Cone, T. E., Jr.; Redmond, R. F.; Maloney, J. V., and Smythe, C. McC.: Evaluation of Some Drugs in Seasickness , J. Pharmacol. & Exper. Therap. 108:69 ( (May) ) 1953. 6. Chinn, H. I.; Handford, S. W.; Smith, P. K.; Cone, T. E.; Redmond, R. F.; Maloney, J. V., and Smythe, C. McC.: Further Evaluation of Drugs for the Prevention of Seasickness, Joint Project 21-32-014, Report 10, United States Navy and United States Air Force, Dec., 1952. 7. Handford, S. W.; Cone, T. E.; Chinn, H. L., and Smith, P. K.: Preventing Motion Sickness at Sea , J. Pharmacol. & Exper. Therap. 111:447 ( (Aug) ). 1954. 8. Atkinson, M.: A Simple Quantitative Method of Testing Vestibular Function , Arch. Otolaryng. 30:916 ( (Dec.) ) 1939. 9. Fowler, E. P.: Medicine of the Ear , in Nelson Loose-Leaf Medicine of the Ear , Ed. 2, New York, Thos. Nelson & Sons, 1948, p. 439. 10. McNally, W. J.: The Physiology of the Vestibular Mechanism in Relation to Vertigo , Ann. Otol. Rhin. & Laryng. 56:514 ( (Sept.) ) 1947. 11. Gutner, L. B.; Gould, W. J., and Batterman, R. C.: Action of Dimenhydrinate (Dramamine) and Other Drugs on Vestibular Function , A. M. A. Arch. Otolaryng. 53:308 ( (March) ) 1951. 12. Gutner, L. B.; Gould, W. J., and Cracovaner, A. J.: Effects of Cyclizine Hydrochloride and Chlorcyclizine Hydrochloride upon Vestibular Function , A. M. A. Arch. Otolaryng. 59:503 ( (April) ) 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

Effect of Meclizine Hydrochloride (Bonamine) upon Vestibular Function: Observations with Notes on Its Value in Comparison with Cyclizine Hydrochloride (Marezine) and Dimenhydrinate (Dramamine)

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1955.03830050039009
Publisher site
See Article on Publisher Site

Abstract

Abstract Despite the many positive claims that have been made as to the efficacy of the various antivertiginous drugs now available, the search for a more effective compound with fewer side-reactions continues. Ideally, such medication, in addition to exhibiting a high degree of labyrinthine depression, should be relatively free of untoward sideeffects and possess an adequate duration of activity, thus eliminating the necessity for frequent administration. The preparation should, of course, be orally active and not interfere with the daily functions of the patient. Needless to say, such a compound has yet to be formulated. One of the newer drugs suggested for use in disturbances of labyrinthine function and associated disorders is meclizine hydrochloride (Parachloramine, Postafene). Chemically, it is the dihydrochloride of 1 -p -chlorobenzhydryl-4-m-methylbenzylpiperazine, having the accompanying structural formula. This compound has been found to possess antihistaminic and anticholinergic properties, either activity theoretically having some potential therapeutic value References 1. References 6 to 8. 2. References 9 and 10. 3. Eurard, E.: Prevention and Treatment of Air Sickness by a New Antihistaminic , Bruxelles univ. méd. 33:173 ( (Jan.) ) 1953. 4. Chinn, H. I.; Gammon, W. R., and Frantz, M. E.: Prevention of Airsickness Among Airborne Troops , J. Appl. Physiol. 5:599 ( (April) ) 1953. 5. Chinn, H. I.; Handford, S. W.; Smith, P. K.; Cone, T. E., Jr.; Redmond, R. F.; Maloney, J. V., and Smythe, C. McC.: Evaluation of Some Drugs in Seasickness , J. Pharmacol. & Exper. Therap. 108:69 ( (May) ) 1953. 6. Chinn, H. I.; Handford, S. W.; Smith, P. K.; Cone, T. E.; Redmond, R. F.; Maloney, J. V., and Smythe, C. McC.: Further Evaluation of Drugs for the Prevention of Seasickness, Joint Project 21-32-014, Report 10, United States Navy and United States Air Force, Dec., 1952. 7. Handford, S. W.; Cone, T. E.; Chinn, H. L., and Smith, P. K.: Preventing Motion Sickness at Sea , J. Pharmacol. & Exper. Therap. 111:447 ( (Aug) ). 1954. 8. Atkinson, M.: A Simple Quantitative Method of Testing Vestibular Function , Arch. Otolaryng. 30:916 ( (Dec.) ) 1939. 9. Fowler, E. P.: Medicine of the Ear , in Nelson Loose-Leaf Medicine of the Ear , Ed. 2, New York, Thos. Nelson & Sons, 1948, p. 439. 10. McNally, W. J.: The Physiology of the Vestibular Mechanism in Relation to Vertigo , Ann. Otol. Rhin. & Laryng. 56:514 ( (Sept.) ) 1947. 11. Gutner, L. B.; Gould, W. J., and Batterman, R. C.: Action of Dimenhydrinate (Dramamine) and Other Drugs on Vestibular Function , A. M. A. Arch. Otolaryng. 53:308 ( (March) ) 1951. 12. Gutner, L. B.; Gould, W. J., and Cracovaner, A. J.: Effects of Cyclizine Hydrochloride and Chlorcyclizine Hydrochloride upon Vestibular Function , A. M. A. Arch. Otolaryng. 59:503 ( (April) ) 1954.

Journal

A.M.A. Archives of Otolaryngology – American Medical Association

Published: Nov 1, 1955

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