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SPONTANEOUS HEMORRHAGE: A Clinical Entity, with Special Reference to Epistaxis

SPONTANEOUS HEMORRHAGE: A Clinical Entity, with Special Reference to Epistaxis Abstract THE CHARACTER and significance of epistaxis have never been understood. In 1941 I proposed the hypothesis that spontaneous hemorrhage is a clinical entity in itself and that epistaxis is the commonest form of this disease.1 Some time later an elaboration of this concept, with a report of 49 patients who had 73 bleeding episodes, was published.2 Since then this study has continued and broadened into other fields, but no similar experience appeared until 1952, when Koch and his associates3 reported five patients with hereditary hemorrhagic telangiectasia relieved by the same means as I had employed. Although I have had the experience of successfully treating well over 300 patients with nosebleeding by the intramuscular administration of estrogens, this contribution contains the important features of the cases of only eight patients with overwhelming epistaxis controlled by huge doses of estrogens administered intravenously. Four other cases of peculiar interest will References 1. Jacobson, P.: Vicarious or Endocrine Bleeding: A New Theory Concerning Spontaneous Hemorrhage , Virginia M. Month. 68:37, 1941. 2. Jacobson, P.: The Psycho-Endocrine Origin and Therapy of Recurrent Spontaneous Hemorrhage , Virginia M. Month. 72:73, 1945. 3. Koch, H. J., Jr.; Escher, G. C., and Lewis, J. S.: Hormonal Management of Hereditary Hemorrhagic Telangiectasia , J. A. M. A. 149:1376, 1952.Crossref 4. Smith, O. W., and Smith, G. V. S.: Studies Concerning the Cause and Purpose of Menstruation , J. Clin. Endocrinol. 6:483, 1946.Crossref 5. Smith, O. W.: Menstrual Toxin: I. Experimental Studies , Am. J. Obst. & Gynec. 54:201, 1947. 6. Smith, G. V. S.: Menstrual Toxin: II. Clinical Significance , Am. J. Obst. & Gynec. 54:212, 1947. 7. Paterson, J. C.: Capillary Rupture with Intimal Hemorrhage as a Causative Factor in Coronary Thrombosis , Arch. Path. 25:474, 1938. 8. Wartman, W. B.: Occlusion of the Coronary Arteries by Hemorrhage into Their Walls , Am. Heart J. 15:459, 1938. 9. Winternitz, M. C.; Thomas, R. M., and LeCompte, P. M.: The Biology of Arteriosclerosis , Springfield, Ill., Charles C Thomas, Publisher, 1938, p. 94. 10. Rivin, A. U., and Dimitroff, S. P.: The Incidence and Severity of Atherosclerosis in Estrogen-Treated Males, and in Females with a Hypoestrogenic or a Hyperestrogenic State , Circulation 9:533, 1954. 11. Jordan, S. M.: Correlation of Gastroenterology and Surgery , J. A. M. A. 138:791, 1948. 12. Lewison, E. F.: Collective Review: Bleeding Peptic Ulcer, in International Abstracts of Surgery , Surg., Gynec. & Obst. 90:1, 1950. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

SPONTANEOUS HEMORRHAGE: A Clinical Entity, with Special Reference to Epistaxis

A.M.A. Archives of Otolaryngology , Volume 59 (5) – May 1, 1954

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1954.00710050535001
Publisher site
See Article on Publisher Site

Abstract

Abstract THE CHARACTER and significance of epistaxis have never been understood. In 1941 I proposed the hypothesis that spontaneous hemorrhage is a clinical entity in itself and that epistaxis is the commonest form of this disease.1 Some time later an elaboration of this concept, with a report of 49 patients who had 73 bleeding episodes, was published.2 Since then this study has continued and broadened into other fields, but no similar experience appeared until 1952, when Koch and his associates3 reported five patients with hereditary hemorrhagic telangiectasia relieved by the same means as I had employed. Although I have had the experience of successfully treating well over 300 patients with nosebleeding by the intramuscular administration of estrogens, this contribution contains the important features of the cases of only eight patients with overwhelming epistaxis controlled by huge doses of estrogens administered intravenously. Four other cases of peculiar interest will References 1. Jacobson, P.: Vicarious or Endocrine Bleeding: A New Theory Concerning Spontaneous Hemorrhage , Virginia M. Month. 68:37, 1941. 2. Jacobson, P.: The Psycho-Endocrine Origin and Therapy of Recurrent Spontaneous Hemorrhage , Virginia M. Month. 72:73, 1945. 3. Koch, H. J., Jr.; Escher, G. C., and Lewis, J. S.: Hormonal Management of Hereditary Hemorrhagic Telangiectasia , J. A. M. A. 149:1376, 1952.Crossref 4. Smith, O. W., and Smith, G. V. S.: Studies Concerning the Cause and Purpose of Menstruation , J. Clin. Endocrinol. 6:483, 1946.Crossref 5. Smith, O. W.: Menstrual Toxin: I. Experimental Studies , Am. J. Obst. & Gynec. 54:201, 1947. 6. Smith, G. V. S.: Menstrual Toxin: II. Clinical Significance , Am. J. Obst. & Gynec. 54:212, 1947. 7. Paterson, J. C.: Capillary Rupture with Intimal Hemorrhage as a Causative Factor in Coronary Thrombosis , Arch. Path. 25:474, 1938. 8. Wartman, W. B.: Occlusion of the Coronary Arteries by Hemorrhage into Their Walls , Am. Heart J. 15:459, 1938. 9. Winternitz, M. C.; Thomas, R. M., and LeCompte, P. M.: The Biology of Arteriosclerosis , Springfield, Ill., Charles C Thomas, Publisher, 1938, p. 94. 10. Rivin, A. U., and Dimitroff, S. P.: The Incidence and Severity of Atherosclerosis in Estrogen-Treated Males, and in Females with a Hypoestrogenic or a Hyperestrogenic State , Circulation 9:533, 1954. 11. Jordan, S. M.: Correlation of Gastroenterology and Surgery , J. A. M. A. 138:791, 1948. 12. Lewison, E. F.: Collective Review: Bleeding Peptic Ulcer, in International Abstracts of Surgery , Surg., Gynec. & Obst. 90:1, 1950.

Journal

A.M.A. Archives of OtolaryngologyAmerican Medical Association

Published: May 1, 1954

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