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L. Stevenson, E. Alvord, J. Correll (1947)
Degeneration and Necrosis of Neurones in Eighth Cranial Nuclei Caused by StreptomycinProceedings of the Society for Experimental Biology and Medicine, 65
J. Winston (1948)
An Experimental Study of the Toxic Effects of Streptomycin on the Vestibular Apparatus of the Cat: Central Nervous SystemAnn. Otol., Rhin. & Laryng., 57
L. Floberg, C. Hamberger, H. Hydén (1949)
Inhibition of nucleic acid production in vestibular nerve cells by streptomycin.Acta oto-laryngologica, 28 Suppl. 75
T. Hunnicutt , W. J. Graf, M. Hamburger, E. B. Ferris (1948)
Fatal Toxic Encephalopathy Apparently Caused by StreptomycinJ. A. M. A., 137
H. Williams (1947)
LIV The Present Status of the Diagnosis and Treatment of Endolymphatic Hydrops (Ménière's Disease)Annals of Otology, Rhinology & Laryngology, 56
R. Farrington, H. HULL-SMITH (1947)
Streptomycin toxicity; reactions to highly purified drug on long-continued administration to human subjects.Journal of the American Medical Association, 134 8
R. Dow (1938)
EFFECT OF LESIONS IN THE VESTIBULAR PART OF THE CEREBELLUM IN PRIMATESJournal of Nervous and Mental Disease, 40
F. R. Ford (1936)
Clinical Observations upon the Importance of the Vestibular Reflexes in Ocular Movements: The Effects of Section of One or Both Vestibular NervesBull. Johns Hopkins Hosp., 58
T. Hunnicutt, W. Graf (1948)
Fatal toxic encephalopathy apparently caused by streptomycin.Journal of the American Medical Association, 137 7
Mushett Cw, Martland Hs (1946)
Pathologic changes resulting from the administration of streptomycin.Archives of pathology, 42
J. Fulton, R. Dow (1937)
The Cerebellum: A Summary of Functional Localization *The Yale Journal of Biology and Medicine, 10
H. A. Brown (1946)
Toxic Reactions of Streptomycin on the Eighth Nerve ApparatusProc. Staff Meet., Mayo Clin., 21
K. Berg (1949)
The Toxic Effect of Streptomycin on the Eighth Cranial NerveAnn. Otol., Rhin. & Laryng., 55
L. Wallner (1949)
The otologic effects of streptomycin therapy.The Annals of otology, rhinology, and laryngology, 58 1
E. Fowler, E. Seligman (1947)
Otic complications of streptomycin therapy; a preliminary report.Journal of the American Medical Association, 133 2
James W. (1882)
The Sense of Dizziness in Deaf-MutesAm. J. Otol., 4
E. Hobhouse (1924)
Aural VertigoLancet, 1
P. Northington (1934)
Effects of Unilateral and Bilateral Labyrinthectomy and Intracranial Section of Eighth Nerve: Experiments on MonkeysArch. Neurol. & Psychiat., 32
R. F. Farrington , H. H. Smith, P. A. Bunn (1947)
Streptomycin Toxicity: Reactions to Highly Purified Drug on Long-Continued Administration to Human SubjectsJ. A. M. A., 134
P. Northington, S. Barrera (1934)
EFFECTS OF UNILATERAL AND BILATERAL LABYRINTHECTOMY AND INTRACRANIAL SECTION OF EIGHTH NERVE: EXPERIMENTS ON MONKEYSJournal of Nervous and Mental Disease, 32
M. Camis, R. Creed (1930)
The physiology of the vestibular apparatusThe American Journal of the Medical Sciences, 180
A. Glorig, E. Fowler (1947)
Tests for labyrinth function following streptomycin therapy.The Annals of otology, rhinology, and laryngology, 56 2
P. Northington (1936)
Hearing in Patients with Intracranial TumorsBull. Neurol. Inst. New York, 5
R. Nó (1933)
VESTIBULO-OCULAR REFLEX ARCJournal of Nervous and Mental Disease, 30
R. S. Dow (1938)
Effect of Lesions in the Vestibular Part of the Cerebellum in PrimatesArch. Neurol. & Psychiat., 40
H. B. Perlman (1944)
Mechanisms of Ocular Movement in ManArch. Otolaryng., 40
E. P. Fowler (1947)
Otitic Complications of Streptomycin TherapyJ. A. M. A., 133
G. Holmes (1938)
The Cerebral Integration of the Ocular MovementsBrit. M. J., 2
J. Winston, F. Lewey, A. Parenteau, P. Marden, Faith Cramer (1948)
LXII An Experimental Study of the Toxic Effects of Streptomycin on the Vestibular Apparatus of the CatAnnals of Otology, Rhinology & Laryngology, 57
R. de No (1933)
Vestibulo-Ocular ReflexArch. Neurol. & Psychiat., 30
I. Jones, W. Spiller (1925)
THE CENTRAL TRACTS OF THE NERVUS VESTIBULARISBrain, 48
W. E. Dandy (1941)
The Surgical Treatment of Ménière's DiseaseSurg., Gynec. & Obst., 72
E. A. Spiegel (1944)
Neurology of the Eye, Ear, Nose and Throat
F. H. Pike (1923)
Function of the Vestibular ApparatusPhysiol. Rev., 3
F. Snell (1948)
Some otic complications of streptomycin therapy.Military surgeon, 102 3
P. Levin (1939)
THE SYNDROME OF VESTIBULAR PARALYSIS IN MANThe Journal of Nervous and Mental Disease, 89
J. Winston (1948)
VESTIBULAR FINDINGS BEFORE, DURING AND AFTER VESTIBULAR DAMAGE RESULTING FROM STREPTOMYCIN THERAPYArchives of Otolaryngology-head & Neck Surgery, 47
J. Chusid, C. Gutiérrez-Mahoney (1946)
THE SYNDROME OF BILATERAL VESTIBULAR PARALYSISThe Journal of Nervous and Mental Disease, 103
P. Northington (1948)
Effects of Streptomycin on Eighth Cranial Nerve Function, read before the Otolaryngologic Scientific Session at the Thirty-Fourth Clinical Congress of the American College of Surgeons
O. Mowrer (1932)
XXXII. Concerning the Normal Function of the Vestibular ApparatusAnnals of Otology, Rhinology & Laryngology, 41
A. Ferraro (1938)
The Effects of Lesions of Various Portions of the Vestibular Complex in the Macaccus RhesusTr. Am. Neurol. A., 64
Abstract THE DISTURBANCE of equilibrium caused by bilateral loss of vestibular function from streptomycin therapy appears to be basically similar to that of bilateral vestibular paralysis from other causes, whether the site of the lesion is in the peripheral or the central components of the vestibular nervous system. The syndrome of bilateral vestibular paralysis has rarely been noted in the literature, and not before its happening as an untoward effect of streptomycin therapy has there been an opportunity to observe a considerable number of patients with this syndrome from its onset and through the stages of its regression. The practice of prescribing smaller doses of streptomycin than formerly and of substituting other antibiotics with less neurotoxic effects makes the study of the symptomatology of the toxicity of streptomycin, including its pathologic foci, of importance chiefly in obtaining a better understanding of disorders of the function of the acoustic nerve as an References 1. Northington, P.: Effects of Streptomycin on Eighth Cranial Nerve Function, read before the Otolaryngologic Scientific Session at the Thirty-Fourth Clinical Congress of the American College of Surgeons , Los Angeles, Calif., (Oct. 20) , 1948. 2. Brown, H. A., and Hinslaw, H. C.: Toxic Reactions of Streptomycin on the Eighth Nerve Apparatus , Proc. Staff Meet., Mayo Clin. 21:347 ( (Sept. 4) ) 1946. 3. Farrington, R. F.; Smith, H. H.; Bunn, P. A., and McDermott, W. L.: Streptomycin Toxicity: Reactions to Highly Purified Drug on Long-Continued Administration to Human Subjects , J. A. M. A. 134:679 ( (June 21) ) 1947.Crossref 4. Fowler, E. P., Jr., and Seligman, E. L.: Otitic Complications of Streptomycin Therapy , J. A. M. A. 133:87 ( (Jan. 11) ) 1947.Crossref 5. Glorig, A., and Fowler, E. P., Jr.: Tests for Labyrinth Function Following Streptomycin Therapy , Ann. Otol., Rhin. & Laryng. 56:379 ( (June) ) 1947. 6. Snell, F. B.: Otitic Complications of Streptomycin Therapy , Mil. Surgeon 102:202 ( (March) ) 1948. 7. Winston, J.: Vestibular Findings Before, During and After Vestibular Damage Resulting from Streptomycin Therapy , Arch. Otolaryng. 77:746 ( (June) ) 1948. 8. Wallner, L. J.: The Otologic Effects of Streptomycin Therapy , Ann. Otol., Rhin. & Laryng. 58:111 ( (March) ) 1949. 9. James W.: The Sense of Dizziness in Deaf-Mutes , Am. J. Otol. 4:239 ( (Oct.) ) 1882. 10. Dandy, W. E.: The Surgical Treatment of Ménière's Disease , Surg., Gynec. & Obst. 72:421 (Feb. no. (2 A) ) 1941. 11. Williams, H. L.: The Present Status of the Diagnosis and Treatment of Endolymphatic Hydrops (Ménière's Disease) , Ann. Otol., Rhin. & Laryng. 56:614 ( (Sept.) ) 1947. 12. Levin, P. M.: The Syndrome of Vestibular Paralysis in Man , J. Nerv. & Ment. Dis. 89:335 ( (March) ) 1939. 13. Chusid, J. G., and de Gutiérrez-Mahoney, C. G.: The Syndrome of Bilateral Vestibular Paralysis , J. Nerv. & Ment. Dis. 103:172 ( (Feb.) ) 1946. 14. Pike, F. H.: Function of the Vestibular Apparatus , Physiol. Rev. 3:209 ( (April) ) 1923. 15. Mowrer, O. H.: Concerning the Normal Function of the Vestibular Apparatus , Ann. Otol., Rhin. & Larygn. 41:412 ( (June) ) 1932. 16. Hobhouse, E.: Aural Vertigo , Lancet 1:821 ( (April) ) 1924. 17. Ferraro, A., and Barrera, S. E.: The Effects of Lesions of Various Portions of the Vestibular Complex in the Macaccus Rhesus , Tr. Am. Neurol. A. 64:69, 1938. 18. Flourens, cited by Fulton and Dow.14 19. Northington, P., and Barrera, S. E.: Effects of Unilateral and Bilateral Labyrinthectomy and Intracranial Section of Eighth Nerve: Experiments on Monkeys , Arch. Neurol. & Psychiat. 32:51 ( (July) ) 1934. 20. Ferraro and Barrera.11 21. Fulton, J. F., and Dow, R. S.: The Cerebellum: A Summary of Functional Localization , Yale J. Biol. & Med. 10:89 ( (Oct.) ) 1937. 22. Dow, R. S.: Effect of Lesions in the Vestibular Part of the Cerebellum in Primates , Arch. Neurol. & Psychiat. 40:500 ( (Sept.) ) 1938. 23. de Kleijn, A., and Magnus, R., cited by Camis, M.: Physiology of the Vestibular Apparatus , translated and annotated by R. S. Creed, London, Oxford University Press, 1930. 24. Lorente de No, R.: Vestibulo-Ocular Reflex , Arch. Neurol. & Psychiat. 30:245 ( (Aug.) ) 1933. 25. Spiegel, E. A., and Sommer, I.: Neurology of the Eye, Ear, Nose and Throat , New York, Grune & Stratton, Inc., 1944. 26. Holmes, G.: The Cerebral Integration of the Ocular Movements , Brit. M. J. 2:4045 ( (July 16) ) 1938. 27. Perlman, H. B., and Case, T. J.: Mechanisms of Ocular Movement in Man , Arch. Otolaryng. 40:457 ( (Sept.) ) 1944.Crossref 28. Fowler, E. P., Jr.: Personal communication to the author. 29. Muschett, C. W., and Martland, H. S.: Pathologic Changes Resulting from the Administration of Streptomycin , Arch. Path. 42:619 ( (Dec.) ) 1947. 30. Berg, K.: The Toxic Effect of Streptomycin on the Eighth Cranial Nerve , Ann. Otol., Rhin. & Laryng. 55:448 ( (June) ) 1949. 31. Stevenson, D.; Alvord, C., and Correll, W.: Degeneration and Necrosis of Neurones in Eighth Cranial Nuclei Caused by Streptomycin , Proc. Soc. Exper. Biol. & Med. 65:86 ( (May) ) 1947. 32. Winston, J., and others: An Experimental Study of the Toxic Effects of Streptomycin on the Vestibular Apparatus of the Cat: Central Nervous System , Ann. Otol., Rhin. & Laryng. 57:738 ( (Sept.) ) 1948. 33. Floberg, L. E.; Hamberger, C. A., and Hydén, H.: Inhibition of Nucleic Acid Production in Vestibular Nerve Cells by Streptomycin , Acta oto-laryng. , 1949, (supp. 75) , p. 36. 34. Hunnicutt, T.; Graf, W. J.; Hamburger, M.; Ferris, E. B., and Scheinker, I. M.: Fatal Toxic Encephalopathy Apparently Caused by Streptomycin , J. A. M. A. 137:599 ( (June 12) ) 1948. 35. Jones, I. H., and Spiller, W. G.: The Central Tracts of the Nervus Vestibularis , Brain 48:334 ( (Sept.) ) 1925. 36. Ford, F. R., and Walsh, F. B.: Clinical Observations upon the Importance of the Vestibular Reflexes in Ocular Movements: The Effects of Section of One or Both Vestibular Nerves , Bull. Johns Hopkins Hosp. 58:80 ( (Feb.) ) 1936. 37. Northington, P.: Hearing in Patients with Intracranial Tumors , Bull. Neurol. Inst. New York 5:289 ( (Aug.) ) 1936.
Archives of Otolaryngology – American Medical Association
Published: Sep 1, 1950
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