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TREATMENT OF HEMORRHAGE IN NONHEMOPHILIC PATIENTS WITH AN ESTROGENIC SUBSTANCE

TREATMENT OF HEMORRHAGE IN NONHEMOPHILIC PATIENTS WITH AN ESTROGENIC SUBSTANCE Abstract The primary investigations of Carrol Birch,1 of Chicago, in 1931 led to the use of ovarian extract in the treatment of hemophilia. Birch reasoned that since the disease occurs only in the male there is something lacking in the male organism which is present in the transmitting female which prevents the development of clinical manifestations of the disease. Working on this theory, she has treated hemophilia with ovarian extract with excellent results, and the use of this in the hands of many others since that time has proved the value of her work. It was also shown that the addition of ovarian substance lowers the coagulation time of blood from a hemophiliac in vitro. At the suggestion of A. J. Carlson, Birch demonstrated that when the urine from normal men is concentrated and injected in sufficient quantities into castrated female rats an estrus cycle is produced. The urine References 1. Birch, Carroll L.: Hemophilia , J. A. M. A. 99:1566-1572 ( (Nov. 15) ) 1932Crossref 2. Hemophilia and the Female Sex Hormone: Preliminary Report , Birch, Carroll L.: J. A. M. A. 97:244 ( (July 25) ) 1931.Crossref 3. Spoto, J. S.: Treatment of Hemophilia with Ovarian Extract: Report of Two Cases , J. Florida M. A. 20:9 ( (July) ) 1933. 4. Howell, W. H.: The Rôle of Antithrombin and Thromboplastin (Thromboplastic Substance) in the Coagulation of Blood , Am. J. Physiol. 29:187, 1911. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

TREATMENT OF HEMORRHAGE IN NONHEMOPHILIC PATIENTS WITH AN ESTROGENIC SUBSTANCE

Archives of Otolaryngology , Volume 24 (6) – Dec 1, 1936

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1936.00640050773008
Publisher site
See Article on Publisher Site

Abstract

Abstract The primary investigations of Carrol Birch,1 of Chicago, in 1931 led to the use of ovarian extract in the treatment of hemophilia. Birch reasoned that since the disease occurs only in the male there is something lacking in the male organism which is present in the transmitting female which prevents the development of clinical manifestations of the disease. Working on this theory, she has treated hemophilia with ovarian extract with excellent results, and the use of this in the hands of many others since that time has proved the value of her work. It was also shown that the addition of ovarian substance lowers the coagulation time of blood from a hemophiliac in vitro. At the suggestion of A. J. Carlson, Birch demonstrated that when the urine from normal men is concentrated and injected in sufficient quantities into castrated female rats an estrus cycle is produced. The urine References 1. Birch, Carroll L.: Hemophilia , J. A. M. A. 99:1566-1572 ( (Nov. 15) ) 1932Crossref 2. Hemophilia and the Female Sex Hormone: Preliminary Report , Birch, Carroll L.: J. A. M. A. 97:244 ( (July 25) ) 1931.Crossref 3. Spoto, J. S.: Treatment of Hemophilia with Ovarian Extract: Report of Two Cases , J. Florida M. A. 20:9 ( (July) ) 1933. 4. Howell, W. H.: The Rôle of Antithrombin and Thromboplastin (Thromboplastic Substance) in the Coagulation of Blood , Am. J. Physiol. 29:187, 1911.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Dec 1, 1936

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