Access the full text.
Sign up today, get DeepDyve free for 14 days.
W. Howell (1911)
THE RÔLE OF ANTITHROMBIN AND THROMBOPLASTIN (THROMBOPLASTIC SUBSTANCE) IN THE COAGULATION OF BLOODAmerican Journal of Physiology, 29
J. S. Spoto (1933)
Treatment of Hemophilia with Ovarian Extract: Report of Two CasesJ. Florida M. A., 20
C. Birch (1931)
HEMOPHILIA AND THE FEMALE SEX HORMONE: PRELIMINARY REPORTJAMA, 97
Carroll L. Birch (1932)
HemophiliaJ. A. M. A., 99
Abstract The primary investigations of Carrol Birch,1 of Chicago, in 1931 led to the use of ovarian extract in the treatment of hemophilia. Birch reasoned that since the disease occurs only in the male there is something lacking in the male organism which is present in the transmitting female which prevents the development of clinical manifestations of the disease. Working on this theory, she has treated hemophilia with ovarian extract with excellent results, and the use of this in the hands of many others since that time has proved the value of her work. It was also shown that the addition of ovarian substance lowers the coagulation time of blood from a hemophiliac in vitro. At the suggestion of A. J. Carlson, Birch demonstrated that when the urine from normal men is concentrated and injected in sufficient quantities into castrated female rats an estrus cycle is produced. The urine References 1. Birch, Carroll L.: Hemophilia , J. A. M. A. 99:1566-1572 ( (Nov. 15) ) 1932Crossref 2. Hemophilia and the Female Sex Hormone: Preliminary Report , Birch, Carroll L.: J. A. M. A. 97:244 ( (July 25) ) 1931.Crossref 3. Spoto, J. S.: Treatment of Hemophilia with Ovarian Extract: Report of Two Cases , J. Florida M. A. 20:9 ( (July) ) 1933. 4. Howell, W. H.: The Rôle of Antithrombin and Thromboplastin (Thromboplastic Substance) in the Coagulation of Blood , Am. J. Physiol. 29:187, 1911.
Archives of Otolaryngology – American Medical Association
Published: Dec 1, 1936
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.