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Diffuse Intranasal Papillomatosis and Its Association With Human Papillomavirus

Diffuse Intranasal Papillomatosis and Its Association With Human Papillomavirus CLINICAL NOTE Diffuse Intranasal Papillomatosis and Its Association With Human Papillomavirus Benjamin S. Bleier, MD; Charles S. Gawthrop, MD; Erica R. Thaler, MD; Duane A. Sewell, MD; Kathleen T. Montone, MD; Douglas M. Marvel, BA; Alexander G. Chiu, MD ntranasal papillomas may be categorized by histologic origin as those arising from squa- mous or schneiderian epithelium. Squamous papillomas result from a proliferation of squa- mous epithelium into exophytic papillary fronds, are almost exclusively unilateral, and are I usually pedicled in the nasal vestibule. Bilateral diffuse intranasal squamous papillomato- sis represents a poorly described variant of this disease, which may represent a distinct pathologic process derived from an underlying human papillomavirus (HPV) infection, and its treatment should address this etiology. We report on 2 rare cases of diffuse intranasal papillomatosis and discuss their presentation, workup, HPV characterization, and treatment. tibular lesion and a resection of the re- REPORT OF CASES maining bilateral lesions utilizing a powered microdebrider (Figure 1). Af- CASE 1 ter complete debridement, the patient un- derwent intralesional injection of cidofo- A 43-year-old man presented to our oto- vir, 5 mg/mL. laryngology clinic with a chief complaint The final pathologic finding from the of left nasal congestion of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

Diffuse Intranasal Papillomatosis and Its Association With Human Papillomavirus

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References (11)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/archotol.134.7.778
pmid
18645131
Publisher site
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Abstract

CLINICAL NOTE Diffuse Intranasal Papillomatosis and Its Association With Human Papillomavirus Benjamin S. Bleier, MD; Charles S. Gawthrop, MD; Erica R. Thaler, MD; Duane A. Sewell, MD; Kathleen T. Montone, MD; Douglas M. Marvel, BA; Alexander G. Chiu, MD ntranasal papillomas may be categorized by histologic origin as those arising from squa- mous or schneiderian epithelium. Squamous papillomas result from a proliferation of squa- mous epithelium into exophytic papillary fronds, are almost exclusively unilateral, and are I usually pedicled in the nasal vestibule. Bilateral diffuse intranasal squamous papillomato- sis represents a poorly described variant of this disease, which may represent a distinct pathologic process derived from an underlying human papillomavirus (HPV) infection, and its treatment should address this etiology. We report on 2 rare cases of diffuse intranasal papillomatosis and discuss their presentation, workup, HPV characterization, and treatment. tibular lesion and a resection of the re- REPORT OF CASES maining bilateral lesions utilizing a powered microdebrider (Figure 1). Af- CASE 1 ter complete debridement, the patient un- derwent intralesional injection of cidofo- A 43-year-old man presented to our oto- vir, 5 mg/mL. laryngology clinic with a chief complaint The final pathologic finding from the of left nasal congestion of

Journal

JAMA Otolaryngology - Head & Neck Surgery – American Medical Association

Published: Jul 1, 2008

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