P181 Combination Tumor Antigen–Targeted Immunotherapy in HPV-16–Positive Head and Neck Squamous Cell Carcinoma
Abstract
Objective: To show that E6-induced proteasomal degradation of p53 in human papillomavirus (HPV) 16–positive head and neck squamous cell carcinoma enhances cytotoxic T-lymphocyte recognition and lysis mediated by increased HLA-A2-p53(264-272) complexes. By directly targeting E7 and p53, we can increase efficacy of adjuvant immunotherapy by avoiding viral mutation and the potential loss of a target. Design: Adjuvant treatment was 5% imiquimod cream (Aldara) or aqueous imiquimod, a...