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Inflammatory Pseudotumor of the Nasopharynx and Skull Base

Inflammatory Pseudotumor of the Nasopharynx and Skull Base CLINICAL NOTE Inflammatory Pseudotumor of the Nasopharynx and Skull Base Mimicking an Aggressive Neoplasm or Infection Wilson B. Chwang, MD, PhD; Ruchika Jain, MD; Ananth Narayan, MD; Jonathan McHugh, MD; Tamer Ghanem, MD; Michael Seidman, MD; Rajan Jain, MD nflammatory pseudotumor of the nasopharynx and skull base is a benign, idiopathic dis- ease that is often mistaken for a neoplasm or infection owing to its aggressive behavior and clinical presentation. It can present as a progressively destructive mass and should be con- I sidered when repeated tissue biopsies reveal acute or chronic inflammation without evi- dence of malignant disease or infection. We present 4 cases of nasopharyngeal inflammatory pseu- dotumor with skull base invasion occurring in patients with diabetes mellitus (DM). These patients had repeated negative results from biopsies and cultures, and none had associated cervical lymph- adenopathy despite having an aggressive destructive mass. We suggest that these findings, coupled with clinical suspicion, will be helpful in making the correct diagnosis of inflammatory pseudo- tumor. This is critical in the management of these patients to institute the correct treatment plan. aggressive treatment with Humulin insu- REPORT OF CASES lin, Novolin insulin, and Lantus. On physical examination, the right side http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

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References (19)

Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/archoto.2012.1540
pmid
22911301
Publisher site
See Article on Publisher Site

Abstract

CLINICAL NOTE Inflammatory Pseudotumor of the Nasopharynx and Skull Base Mimicking an Aggressive Neoplasm or Infection Wilson B. Chwang, MD, PhD; Ruchika Jain, MD; Ananth Narayan, MD; Jonathan McHugh, MD; Tamer Ghanem, MD; Michael Seidman, MD; Rajan Jain, MD nflammatory pseudotumor of the nasopharynx and skull base is a benign, idiopathic dis- ease that is often mistaken for a neoplasm or infection owing to its aggressive behavior and clinical presentation. It can present as a progressively destructive mass and should be con- I sidered when repeated tissue biopsies reveal acute or chronic inflammation without evi- dence of malignant disease or infection. We present 4 cases of nasopharyngeal inflammatory pseu- dotumor with skull base invasion occurring in patients with diabetes mellitus (DM). These patients had repeated negative results from biopsies and cultures, and none had associated cervical lymph- adenopathy despite having an aggressive destructive mass. We suggest that these findings, coupled with clinical suspicion, will be helpful in making the correct diagnosis of inflammatory pseudo- tumor. This is critical in the management of these patients to institute the correct treatment plan. aggressive treatment with Humulin insu- REPORT OF CASES lin, Novolin insulin, and Lantus. On physical examination, the right side

Journal

JAMA Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Aug 1, 2012

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