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CLINICAL NOTE Inflammatory Pseudotumor of the Nasopharynx and Skull Base Mimicking an Aggressive Neoplasm or Infection Wilson B. Chwang, MD, PhD; Ruchika Jain, MD; Ananth Narayan, MD; Jonathan McHugh, MD; Tamer Ghanem, MD; Michael Seidman, MD; Rajan Jain, MD nflammatory pseudotumor of the nasopharynx and skull base is a benign, idiopathic dis- ease that is often mistaken for a neoplasm or infection owing to its aggressive behavior and clinical presentation. It can present as a progressively destructive mass and should be con- I sidered when repeated tissue biopsies reveal acute or chronic inflammation without evi- dence of malignant disease or infection. We present 4 cases of nasopharyngeal inflammatory pseu- dotumor with skull base invasion occurring in patients with diabetes mellitus (DM). These patients had repeated negative results from biopsies and cultures, and none had associated cervical lymph- adenopathy despite having an aggressive destructive mass. We suggest that these findings, coupled with clinical suspicion, will be helpful in making the correct diagnosis of inflammatory pseudo- tumor. This is critical in the management of these patients to institute the correct treatment plan. aggressive treatment with Humulin insu- REPORT OF CASES lin, Novolin insulin, and Lantus. On physical examination, the right side
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Aug 1, 2012
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