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Salvage Treatment of Late Neck Metastasis in Esthesioneuroblastoma

Salvage Treatment of Late Neck Metastasis in Esthesioneuroblastoma ORIGINAL ARTICLE Salvage Treatment of Late Neck Metastasis in Esthesioneuroblastoma A Meta-analysis Mitchell R. Gore, MD, PhD; Adam M. Zanation, MD Objective: Esthesioneuroblastoma (ENB) is an uncom- vival for at least 1 year, was compared for the 3 treat- mon tumor of the sinonasal region with a 20% rate of ment groups. neck metastases. To our knowledge, the rate of neck me- tastases occurring 6 or more months after diagnosis has Results: The rate of cervical metastases was 20.2%, with not been well characterized. The rate of successful sal- a 12.4% rate of late neck metastases. The combined suc- vage of these late neck metastases, defined in this study cessful salvage rate for late neck metastases with sur- as disease-free survival for at least 1 year, has not been gery, radiation, or combined therapy was 31.2%. An odds previously reported. ratio (OR) analysis revealed that surgery plus radiation provided a statistically significant increase in the rate of Design: Meta-analysis examining 33 articles published successful salvage in patients with late neck metastases, since 1990. with an OR of 8.6 vs single modality therapy and a num- ber-needed-to-treat of 3. We found no difference in the Patients: A total of 678 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

Salvage Treatment of Late Neck Metastasis in Esthesioneuroblastoma

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References (47)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/archoto.2009.143
pmid
19841344
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Salvage Treatment of Late Neck Metastasis in Esthesioneuroblastoma A Meta-analysis Mitchell R. Gore, MD, PhD; Adam M. Zanation, MD Objective: Esthesioneuroblastoma (ENB) is an uncom- vival for at least 1 year, was compared for the 3 treat- mon tumor of the sinonasal region with a 20% rate of ment groups. neck metastases. To our knowledge, the rate of neck me- tastases occurring 6 or more months after diagnosis has Results: The rate of cervical metastases was 20.2%, with not been well characterized. The rate of successful sal- a 12.4% rate of late neck metastases. The combined suc- vage of these late neck metastases, defined in this study cessful salvage rate for late neck metastases with sur- as disease-free survival for at least 1 year, has not been gery, radiation, or combined therapy was 31.2%. An odds previously reported. ratio (OR) analysis revealed that surgery plus radiation provided a statistically significant increase in the rate of Design: Meta-analysis examining 33 articles published successful salvage in patients with late neck metastases, since 1990. with an OR of 8.6 vs single modality therapy and a num- ber-needed-to-treat of 3. We found no difference in the Patients: A total of 678

Journal

JAMA Otolaryngology - Head & Neck Surgery – American Medical Association

Published: Oct 1, 2009

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