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LABORATORY SCIENCES ONLINE FIRST Lack of Thrombospondin 1 and Exacerbation of Choroidal Neovascularization Shoujian Wang, MD, PhD; Christine M. Sorenson, PhD; Nader Sheibani, PhD Objectives: To assess the impact of thrombospondin 1 pared with TSP1/ mice. This was consistent with en- (TSP1) deficiency on choroidal neovascularization (CNV) hanced recruitment of macrophages in TSP1−/− mice com- and to determine whether administration of a TSP1 an- pared with TSP1/ mice 3 days postlaser. The tiangiogenic mimetic peptide attenuates CNV. development of CNV was significantly attenuated in mice receiving the TSP1 antiangiogenic mimetic peptide com- Methods: The impact of TSP1 deficiency on laser- pared with those receiving vehicle alone. induced CNV was assessed using wild-type (TSP1/) and TSP1-deficient (TSP1−/−) mice. Three laser burns were Conclusions: Deficiency of TSP1 contributes to en- placed in each eye of TSP1/ and TSP1−/− mice to in- hanced choroidal neovascularization. This is consistent duce CNV. Intravitreal injection of the TSP1 mimetic pep- with the anti-inflammatory and antiangiogenic activity tide was performed on days 1 and 7 postlaser in the mice. of TSP1. The TSP1 antiangiogenic peptide was effective For quantitative measurements of neovascularization, in- in attenuation of CNV. tercellular adhesion molecule 2 staining was performed at 14
JAMA Ophthalmology – American Medical Association
Published: May 1, 2012
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