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CLINICAL SCIENCES ONLINE FIRST Relationship Among CFH and ARMS2 Genotypes, Macular Pigment Optical Density, and Neuroretinal Function in Persons Without Age-Related Macular Degeneration Beatrix Feigl, MD, PhD; C. Phillip Morris, PhD; Brian Brown, PhD; Andrew J. Zele, PhD Objectives: To determine whether there is a differ- pants with low-risk genotypes and in persons with early ence in neuroretinal function and in macular pigment op- AMD after correction for age and smoking (P .05). The tical density between persons with high- and low-risk gene group peak-implicit times for ring 1 were, on average, variants for age-related macular degeneration (AMD) and delayed in the patients with early AMD compared with no ophthalmoscopic signs of AMD, and to compare the the participants with high- or low-risk genotypes, al- results on neuroretinal function to patients with mani- though these differences were not significant. There was fest early AMD. no significant correlation between genotypes and macu- lar pigment optical density. Methods: Neuroretinal function was assessed with the multifocal electroretinogram for 32 participants (22 healthy Conclusions: Increased neuroretinal activity in persons persons with no AMD and 10 patients with early AMD). who carry high-risk AMD genotypes may be due to ge- The 22 healthy participants
JAMA Ophthalmology – American Medical Association
Published: Nov 1, 2012
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