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Metabolic Memory in Diabetes Is True Long-term Memory

Metabolic Memory in Diabetes Is True Long-term Memory EDITORIAL Metabolic Memory in Diabetes Is True Long-term Memory N 1993, THE DIABETES CONTROL AND COMPLI- lactosemic dogs, which develop a retinopathy that is simi- cations Trial’s (DCCT’s) demonstration that strict lar in many respects to nonproliferative diabetic reti- control of blood glucose to near-normal levels nopathy in humans (pericyte loss, microaneurysms, and during an average of 6.5 years in subjects with acellular capillaries). Much earlier, Caird et al made the I type 1 diabetes significantly reduced the pro- astute observation that their young diabetic patients who gression of retinopathy as well as other chronic micro- maintained good control of their blood glucose during vascular complications of the disease was among the most the first 5 years of their diabetes seemed to be protected important results from a randomized controlled clinical from the later development of severe retinopathy. In 1990, 1 10 trial in medical history. This was followed, a few years Roy and his collaborators reported increased fibronec- later, by the results of another randomized controlled trial, tin messenger RNA levels, which persisted long after the the United Kingdom Prospective Diabetes Study, which restoration of near normoglycemia, in the kidney cortex demonstrated the same result for subjects with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Metabolic Memory in Diabetes Is True Long-term Memory

Frank, Robert N.
JAMA Ophthalmology , Volume 127 (3) – Mar 1, 2009
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References (22)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/archophthalmol.2008.607
pmid
19273799
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Metabolic Memory in Diabetes Is True Long-term Memory N 1993, THE DIABETES CONTROL AND COMPLI- lactosemic dogs, which develop a retinopathy that is simi- cations Trial’s (DCCT’s) demonstration that strict lar in many respects to nonproliferative diabetic reti- control of blood glucose to near-normal levels nopathy in humans (pericyte loss, microaneurysms, and during an average of 6.5 years in subjects with acellular capillaries). Much earlier, Caird et al made the I type 1 diabetes significantly reduced the pro- astute observation that their young diabetic patients who gression of retinopathy as well as other chronic micro- maintained good control of their blood glucose during vascular complications of the disease was among the most the first 5 years of their diabetes seemed to be protected important results from a randomized controlled clinical from the later development of severe retinopathy. In 1990, 1 10 trial in medical history. This was followed, a few years Roy and his collaborators reported increased fibronec- later, by the results of another randomized controlled trial, tin messenger RNA levels, which persisted long after the the United Kingdom Prospective Diabetes Study, which restoration of near normoglycemia, in the kidney cortex demonstrated the same result for subjects with

Journal

JAMA Ophthalmology – American Medical Association

Published: Mar 1, 2009

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