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Risk Factors for Open-angle Glaucoma: The Barbados Eye Study

Risk Factors for Open-angle Glaucoma: The Barbados Eye Study Abstract We read with interest the report of the Barbados Eye Study1 in which Leske and associates reportedly failed to identify blood pressure (BP) as a "risk factor" for primary open-angle glaucoma (POAG). While there were many differences between their study and the Baltimore Eye Survey (which included 2500 African-Americans aged 40 years and older), the Baltimore study was able to identify a complex, biologically plausible relationship between BP and the risk of POAG.2 As we had anticipated, two interesting results came from our analyses. There was moderate evidence to suggest that elevated BP was protective at younger ages, presumably before significant vascular narrowing had occurred. Elevated BP was deleterious in the older age group, perhaps because vascular stenosis from chronic hypertension had reduced perfusion despite an elevated pressure head. There was also a marked relationship between perfusion pressure (BP minus intraocular pressure[IOP]) and the risk of POAG that References 1. Leske MC, Connell AMS, Wu S-Y, Hyman LG, Schachat AP, the Barbados Eye Study Group. Risk factors for open-angle glaucoma. The Barbados Eye Study . Arch Ophthalmol . 1995;113:918-924.Crossref 2. Tielsch JM, Katz J. Sommer A, Quigley HA, Javitt JG. Hypertension, perfusion pressure, and primary open-angle glaucoma: a population-based assessment . Arch Ophthalmol . 1995;113:216-221.Crossref 3. Sommer A. Glaucoma: facts and fancies; the Doyne Memorial Lecture. Eye. In press. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Risk Factors for Open-angle Glaucoma: The Barbados Eye Study

Sommer, Alfred; Tielsch, James M.
Archives of Ophthalmology , Volume 114 (2) – Feb 1, 1996
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Risk Factors for Open-angle Glaucoma: The Barbados Eye Study

Abstract

Abstract We read with interest the report of the Barbados Eye Study1 in which Leske and associates reportedly failed to identify blood pressure (BP) as a "risk factor" for primary open-angle glaucoma (POAG). While there were many differences between their study and the Baltimore Eye Survey (which included 2500 African-Americans aged 40 years and older), the Baltimore study was able to identify a complex, biologically plausible relationship between BP and the risk of POAG.2 As we had...
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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1996.01100130229029
Publisher site
See Article on Publisher Site

Abstract

Abstract We read with interest the report of the Barbados Eye Study1 in which Leske and associates reportedly failed to identify blood pressure (BP) as a "risk factor" for primary open-angle glaucoma (POAG). While there were many differences between their study and the Baltimore Eye Survey (which included 2500 African-Americans aged 40 years and older), the Baltimore study was able to identify a complex, biologically plausible relationship between BP and the risk of POAG.2 As we had anticipated, two interesting results came from our analyses. There was moderate evidence to suggest that elevated BP was protective at younger ages, presumably before significant vascular narrowing had occurred. Elevated BP was deleterious in the older age group, perhaps because vascular stenosis from chronic hypertension had reduced perfusion despite an elevated pressure head. There was also a marked relationship between perfusion pressure (BP minus intraocular pressure[IOP]) and the risk of POAG that References 1. Leske MC, Connell AMS, Wu S-Y, Hyman LG, Schachat AP, the Barbados Eye Study Group. Risk factors for open-angle glaucoma. The Barbados Eye Study . Arch Ophthalmol . 1995;113:918-924.Crossref 2. Tielsch JM, Katz J. Sommer A, Quigley HA, Javitt JG. Hypertension, perfusion pressure, and primary open-angle glaucoma: a population-based assessment . Arch Ophthalmol . 1995;113:216-221.Crossref 3. Sommer A. Glaucoma: facts and fancies; the Doyne Memorial Lecture. Eye. In press.

Journal

Archives of Ophthalmology – American Medical Association

Published: Feb 1, 1996

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