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Cutaneous Melanoma-Associated Retinopathy With Retinal Periphlebitis

Cutaneous Melanoma-Associated Retinopathy With Retinal Periphlebitis Abstract Melanoma-associated retinopathy (MAR) is a visual paraneoplastic syndrome occurring in some patients with metastatic cutaneous malignant melanoma. These patients present with a sudden onset of night blindness; the electroretinograms (ERGs) resemble congenital stationary night blindness with myopia1; and their sera produce heavy immunostaining of the rod bipolar cells in the retina.2 We describe a patient with MAR who also had an unusual angiographic finding of retinal periphlebitis that mimicked retinal vasculitis. Report of a Case. A 52-year-old white man was examined on April 28, 1993, because of decreased visual acuity in both eyes of 2 months' duration and decreased night vision for 2 weeks. He had no history of night blindness or other visual or ocular problems, and there was no family history of night blindness or retinal degeneration. Metastatic cutaneous malignant melanoma of the back had been diagnosed in November 1990 and during the subsequent 2 years References 1. Berson EL, Lessell S. Paraneoplastic night blindness with malignant melanoma . Am J Ophthalmol . 1988;106:307-311.Crossref 2. Milam AH, Saari JC, Jacobson SG, et al. Autoantibodies against retinal bipolar cells in cutaneous melanoma-associated retinopathy . Invest Ophthalmol Vis Sci . 1993;34:91-100. 3. Thirkill CE, Fitzgerald P, Sergott RC, et al. Cancer associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic nerve, and cancer cells . N Engl J Med . 1989;321:1589-1594.Crossref 4. Milam AH. Paraneoplastic retinopathy: CAR and MAR. Djamgoz MBA, Archer SN, Vallerga S, eds. Neurobiology & Clinical Aspects of the Outer Retina. London, England: Chapman & Hall. In press. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Cutaneous Melanoma-Associated Retinopathy With Retinal Periphlebitis

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1995.01100070024015
Publisher site
See Article on Publisher Site

Abstract

Abstract Melanoma-associated retinopathy (MAR) is a visual paraneoplastic syndrome occurring in some patients with metastatic cutaneous malignant melanoma. These patients present with a sudden onset of night blindness; the electroretinograms (ERGs) resemble congenital stationary night blindness with myopia1; and their sera produce heavy immunostaining of the rod bipolar cells in the retina.2 We describe a patient with MAR who also had an unusual angiographic finding of retinal periphlebitis that mimicked retinal vasculitis. Report of a Case. A 52-year-old white man was examined on April 28, 1993, because of decreased visual acuity in both eyes of 2 months' duration and decreased night vision for 2 weeks. He had no history of night blindness or other visual or ocular problems, and there was no family history of night blindness or retinal degeneration. Metastatic cutaneous malignant melanoma of the back had been diagnosed in November 1990 and during the subsequent 2 years References 1. Berson EL, Lessell S. Paraneoplastic night blindness with malignant melanoma . Am J Ophthalmol . 1988;106:307-311.Crossref 2. Milam AH, Saari JC, Jacobson SG, et al. Autoantibodies against retinal bipolar cells in cutaneous melanoma-associated retinopathy . Invest Ophthalmol Vis Sci . 1993;34:91-100. 3. Thirkill CE, Fitzgerald P, Sergott RC, et al. Cancer associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic nerve, and cancer cells . N Engl J Med . 1989;321:1589-1594.Crossref 4. Milam AH. Paraneoplastic retinopathy: CAR and MAR. Djamgoz MBA, Archer SN, Vallerga S, eds. Neurobiology & Clinical Aspects of the Outer Retina. London, England: Chapman & Hall. In press.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1995

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