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Giant-Cell Reaction in Surgically Excised Subretinal Neovascular Membrane

Giant-Cell Reaction in Surgically Excised Subretinal Neovascular Membrane Abstract Surgical excision of subretinal neovascular membrane is a treatment currently offered for selected patients with subfoveal neovascularization.1 Pathologic study of excised membranes has provided insight into the pathogenesis of subretinal neovascularization.2 We report herein a case in which pathologic examination of an excised membrane revealed a foreign-body giant-cell reaction. Report of a Case. —A 79-year-old white woman was examined for subfoveal neovascularization in her left eye. The patient had a history of age-related macular degeneration and had previously undergone laser photocoagulation in her right eye. The patient's medical history was significant for non-insulin-dependent diabetes mellitus. Initial examination revealed that the patient's visual acuity was counting fingers at 1 ft in her right eye and 20/60 OS.External examination showed mild blepharitis and cataracts in both eyes. Fundus examination showed a posterior vitreous detachment and scattered discrete nodular drusen in both eyes. There was no evidence of intraocular inflammation. References 1. Lambert HM, Capone AC, Aaberg TM, Sternberg P Jr, Lopez PF. Surgical excision of subfoveal neovascular membranes . Am J Ophthalmol . 1992;113:257-262. 2. Lopez PF, Grossniklaus HE, Lambert HM, et al. Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration . Am J Ophthalmol . 1991;112:647-656. 3. Penfold PL, Killingsworth MC, Sarks SH. Senile macular degeneration: the involvement of immunocompetent cells . Graefes Arch Exp Ophthalmol . 1985;223:69-76.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Giant-Cell Reaction in Surgically Excised Subretinal Neovascular Membrane

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1993.01090060020010
Publisher site
See Article on Publisher Site

Abstract

Abstract Surgical excision of subretinal neovascular membrane is a treatment currently offered for selected patients with subfoveal neovascularization.1 Pathologic study of excised membranes has provided insight into the pathogenesis of subretinal neovascularization.2 We report herein a case in which pathologic examination of an excised membrane revealed a foreign-body giant-cell reaction. Report of a Case. —A 79-year-old white woman was examined for subfoveal neovascularization in her left eye. The patient had a history of age-related macular degeneration and had previously undergone laser photocoagulation in her right eye. The patient's medical history was significant for non-insulin-dependent diabetes mellitus. Initial examination revealed that the patient's visual acuity was counting fingers at 1 ft in her right eye and 20/60 OS.External examination showed mild blepharitis and cataracts in both eyes. Fundus examination showed a posterior vitreous detachment and scattered discrete nodular drusen in both eyes. There was no evidence of intraocular inflammation. References 1. Lambert HM, Capone AC, Aaberg TM, Sternberg P Jr, Lopez PF. Surgical excision of subfoveal neovascular membranes . Am J Ophthalmol . 1992;113:257-262. 2. Lopez PF, Grossniklaus HE, Lambert HM, et al. Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration . Am J Ophthalmol . 1991;112:647-656. 3. Penfold PL, Killingsworth MC, Sarks SH. Senile macular degeneration: the involvement of immunocompetent cells . Graefes Arch Exp Ophthalmol . 1985;223:69-76.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Jun 1, 1993

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