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Recovery From Severe Visual Loss in Optic Neuritis

Recovery From Severe Visual Loss in Optic Neuritis Abstract To the Editor. —In our report of the results of the Optic Neuritis Treatment Trial1 and a subsequent article2 in the Archives, we recommended that intravenous methylprednisolone sodium succinate (250 mg every 6 hours for 3 days) followed by oral prednisone (1 mg/kg per day for 11 days) be considered for treatment of those patients with acute optic neuritis whose visual acuity decreased to less than 20/40. We concluded that there was no benefit to treatment with oral prednisone alone.Since most of the benefit of the intravenous regimen followed by the oral regimen is in the rate of recovery and not in the outcome at 6 months, the decision whether to recommend this regimen or no treatment to a patient with acute optic neuritis is not an easy one. Herein, we provide additional data to assist the clinician making this determination.As can be seen in the References 1. Beck RW, Cleary PA, Anderson MA, et al. A randomized controlled trial of corticosteroids in the treatment of acute optic neuritis . N Engl J Med . 1992;326:581-588.Crossref 2. Optic Neuritis Study Group. The clinical profile of optic neuritis: experience of the Optic Neuritis Treatment Trial . Arch Ophthalmol . 1991;109:1673-1678.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Recovery From Severe Visual Loss in Optic Neuritis

Archives of Ophthalmology , Volume 111 (3) – Mar 1, 1993

Recovery From Severe Visual Loss in Optic Neuritis

Abstract

Abstract To the Editor. —In our report of the results of the Optic Neuritis Treatment Trial1 and a subsequent article2 in the Archives, we recommended that intravenous methylprednisolone sodium succinate (250 mg every 6 hours for 3 days) followed by oral prednisone (1 mg/kg per day for 11 days) be considered for treatment of those patients with acute optic neuritis whose visual acuity decreased to less than 20/40. We concluded that there was no benefit to treatment with oral prednisone...
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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1993.01090030018009
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —In our report of the results of the Optic Neuritis Treatment Trial1 and a subsequent article2 in the Archives, we recommended that intravenous methylprednisolone sodium succinate (250 mg every 6 hours for 3 days) followed by oral prednisone (1 mg/kg per day for 11 days) be considered for treatment of those patients with acute optic neuritis whose visual acuity decreased to less than 20/40. We concluded that there was no benefit to treatment with oral prednisone alone.Since most of the benefit of the intravenous regimen followed by the oral regimen is in the rate of recovery and not in the outcome at 6 months, the decision whether to recommend this regimen or no treatment to a patient with acute optic neuritis is not an easy one. Herein, we provide additional data to assist the clinician making this determination.As can be seen in the References 1. Beck RW, Cleary PA, Anderson MA, et al. A randomized controlled trial of corticosteroids in the treatment of acute optic neuritis . N Engl J Med . 1992;326:581-588.Crossref 2. Optic Neuritis Study Group. The clinical profile of optic neuritis: experience of the Optic Neuritis Treatment Trial . Arch Ophthalmol . 1991;109:1673-1678.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1993

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