Corneal Toxicity From Acidic Vancomycin Solution
Abstract
Abstract To the Editor. —Pflugfelder and Murchison1 reported a case of corneal toxicity with a 12-hour collagen shield soaked in tobramycin sulfate (40 mg/mL), vancomycin hydrochloride (50 mg/mL), and dexamethasone sodium phosphate (4 mg/mL) in the January 1992 issue of the Archives. When reconstituted in water, vancomycin has a pH of 2.5 to 4.5. Topical application of a solution with such a low pH to the cornea is toxic, whether or not a collagen shield is used. A collagen shield...