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Histopathologic Results of Retinal Diode Laser Photocoagulation in Rabbit Eyes

Histopathologic Results of Retinal Diode Laser Photocoagulation in Rabbit Eyes Abstract • Diode laser photocoagulation was applied to rabbit retina simulating scatter treatment using an endolaser probe and in a manner simulating treatment of peripheral retinal breaks using a transscleral retinopexy probe. Clinically appearing mild, moderate, and severe burns were created by altering the burn duration in one eye and by altering the power setting in the fellow eye. Histopathologic results demonstrated the clinically evident dose-response effect with sparing of inner retinal cellular elements with mild burns and full-thickness retinal cell loss with severe burns. Bruch's membrane ruptures were seen in three of 42 endophotocoagulation severe spots placed with high power, but in none of the 42 severe spots placed with long burn duration. Thus, longer burn duration appeared to be a safer way to produce a severe burn than higher power. Burns characteristically bloomed during the several seconds following laser application by both modalities, possibly indicating a deep source of energy absorption. Scleral effects, seen only when high energy levels were used to treat atrophic areas, were mild. References 1. Brancato R, Pratesi R. Applications of diode laser in ophthalmology . Lasers Light Ophthalmol . 1987;1:119-129. 2. Puliafito CA, Deutsch TF, Holl JK. Semiconductor laser endophotocoagulation of the retina . Arch Ophthalmol . 1987;105:424-427.Crossref 3. Duker JS, Federman JL, Schubert HD, Talboc C. Semiconductor diode laser endophotocoagulation . Ophthalmic Surg . 1989;20:717-719. 4. Brancato R, Pratesi R, Leoni G, Trabucchi G, Giovannoni L, Vanni U. Retinal photocoagulation with diode laser operating from a slit lamp microscope . Lasers Light Ophthalmol . 1988;2:73-78. 5. McHugh JDA, Marshall J, Capon M, Rothery S, Raven A, Naylor RP. Transpupillary retinal photocoagulation in the eyes of rabbit and human using a diode laser . Lasers Light Ophthalmol . 1988;2:125-143. 6. McHugh JDA, Marshall J, Ffytche TJ, Hamilton AM, Raven A, Keeler CR. Initial clinical experience using a diode laser in the treatment of retinal vascular disease . Eye . 1989;3:516-527.Crossref 7. McHugh JDA, Marshall J, Ffytche TJ, Hamilton AM, Raven A. Macular photocoagulation of human retina with a diode laser: a comparative histopathological study . Lasers Light Ophthalmol . 1990;3:11-28. 8. Balles MW, Puliafito CA, D'Amico DJ, Jacobsen JJ, Birngruber R. Semiconductor diode laser photocoagulation in retinal vascular disease . Ophthalmology . 1990;97:1553-1561.Crossref 9. Noyori K, Noyori S, Ohki R. Clinical trial of diode laser photocoagulator: preliminary report . Lasers Light Ophthalmol . 1990;3:81-87. 10. Wallow IHL, Sponsel WE, Stevens TS. Clinicopathologic correlation of diode laser burns in monkeys . Arch Ophthalmol . 1991;109:648-653.Crossref 11. Benner JD, Huang M, Ishigooka H, et al. A comparison of argon, krypton and diode binocular indirect ophthalmoscopic laser photocoagulation in the rabbit . Invest Ophthalmol Vis Sci . 1991;32:2764. 12. Avery RL, Repka MX, Green WR, D'Anna S, Goldberg MF. A comparative study of diode and argon laser indirect photocoagulation of primate retina . Invest Ophthalmol Vis Sci . 1991;32( (suppl) ):2766. 13. Jennings T, Fuller T, Vukich JA, et al. Trans-scleral retinal photocoagulation with an 810-nm semiconductor diode laser . Ophthalmic Surg . 1990;21:492-496. 14. Peyman GA, Naguib K, Gaasterland DE. Trans-scleral application of semi-conductor diode laser . Lasers Surg Med . 1990;10:569-575.Crossref 15. Okamoto S. Takahashi H, Fukado Y, Ozawa T. Laser diode application for trans-scleral photocoagulation . Lasers Light Ophthalmol . 1990;3:29-37. 16. Marshall J, Bird A. A comparative histopathologic study of argon and krypton laser irradiations of the human retina . Br J Ophthalmol . 1979;63:657-668.Crossref 17. Peyman GA, Li M, Yoneya S, Goldberg MF, Raichand M. Fundus photocoagulation with the argon and krypton lasers: a comparative study . Ophthalmic Surg . 1981;12:481-490. 18. Smiddy WE, Fine SL, Quigley AJ, Hohman RM, Addicks EM. Comparison of krypton and argon laser photocoagulation in primate retina . Arch Ophthalmol . 1984;102:1086-1092.Crossref 19. Blankenship GW, Gerke E, Batlle JF. Red krypton and blue-green argon laser diabetic panretinal photocoagulation . Graefes Arch Clin Exp Ophthalmol . 1989;227:364-368.Crossref 20. L'Esperance FA. The ocular histopathologic effect of krypton and argon laser radiation . Am J Ophthalmol . 1969;68:263-273. 21. Blankenship GW. Red krypton and bluegreen argon panretinal laser photocoagulation for proliferative diabetic retinopathy: a laboratory and clinical comparison . Trans Am Ophthalmol Soc . 1986;84:967-1003. 22. Macular Photocoagulation Study Group. Argon laser photocoagulation for senile macular degeneration: results of a randomized trial . Arch Ophthalmol . 1982;100:912-918.Crossref 23. Beetham WP, Aiello LM, Balodinos MC, Koncz L. Ruby laser photocoagulation of early diabetic retinopathy: a preliminary report . Trans Am Ophthalmol Soc . 1969;67:40-67. 24. Diabetic Retinopathy Study Research Group. Photocoagulation of proliferative diabetic retinopathy: the second report of the diabetic retinopathy study findings . Ophthalmology . 1978;85:82-105.Crossref 25. Early Treatment Diabetic Retinopathy Study Group. Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema: Early Treatment Diabetic Retinopathy Study report number 2 . Ophthalmology . 1987;94:761-774.Crossref 26. Campbell CJ, Ritter MC, Noyori KS, Swope GH, Koester CJ. The threshold of the retina to damage by laser energy . Arch Ophthalmol . 1966;76:437-442.Crossref 27. Peyman GA, Katoh N, Tawakol M, Khoobehi B, Federman J. Trans-scleral and intravitreal contact Nd: YAG laser application . Retina . 1987;7:190-197.Crossref 28. Geeraets WJ, Berry ER. Ocular special characteristics as related to hazards from lasers and other light sources . Am J Ophthalmol . 1968;66:15-20. 29. Birngruber R, Hillenkamp F, Gabel V-P. Theoretical investigations of laser thermal retinal injury . Health Phys . 1985;48:781-796.Crossref 30. Boettner EA, Wolter JR. Transmission of the ocular media . Invest Ophthalmol Vis Sci . 1962;1:776-783. 31. Balles MW, Puliafito CA, Kliman GH, El-Koumy HA, Reidy WT. Indocyanine green dye enhanced diode laser photocoagulation of subretinal neovascular membranes . Invest Ophthalmol Vis Sci . 1990;31( (suppl) ):282. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Histopathologic Results of Retinal Diode Laser Photocoagulation in Rabbit Eyes

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References (34)

Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1992.01080170115037
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Abstract

Abstract • Diode laser photocoagulation was applied to rabbit retina simulating scatter treatment using an endolaser probe and in a manner simulating treatment of peripheral retinal breaks using a transscleral retinopexy probe. Clinically appearing mild, moderate, and severe burns were created by altering the burn duration in one eye and by altering the power setting in the fellow eye. Histopathologic results demonstrated the clinically evident dose-response effect with sparing of inner retinal cellular elements with mild burns and full-thickness retinal cell loss with severe burns. Bruch's membrane ruptures were seen in three of 42 endophotocoagulation severe spots placed with high power, but in none of the 42 severe spots placed with long burn duration. Thus, longer burn duration appeared to be a safer way to produce a severe burn than higher power. Burns characteristically bloomed during the several seconds following laser application by both modalities, possibly indicating a deep source of energy absorption. Scleral effects, seen only when high energy levels were used to treat atrophic areas, were mild. References 1. Brancato R, Pratesi R. Applications of diode laser in ophthalmology . Lasers Light Ophthalmol . 1987;1:119-129. 2. Puliafito CA, Deutsch TF, Holl JK. Semiconductor laser endophotocoagulation of the retina . Arch Ophthalmol . 1987;105:424-427.Crossref 3. Duker JS, Federman JL, Schubert HD, Talboc C. Semiconductor diode laser endophotocoagulation . Ophthalmic Surg . 1989;20:717-719. 4. Brancato R, Pratesi R, Leoni G, Trabucchi G, Giovannoni L, Vanni U. Retinal photocoagulation with diode laser operating from a slit lamp microscope . Lasers Light Ophthalmol . 1988;2:73-78. 5. McHugh JDA, Marshall J, Capon M, Rothery S, Raven A, Naylor RP. Transpupillary retinal photocoagulation in the eyes of rabbit and human using a diode laser . Lasers Light Ophthalmol . 1988;2:125-143. 6. McHugh JDA, Marshall J, Ffytche TJ, Hamilton AM, Raven A, Keeler CR. Initial clinical experience using a diode laser in the treatment of retinal vascular disease . Eye . 1989;3:516-527.Crossref 7. McHugh JDA, Marshall J, Ffytche TJ, Hamilton AM, Raven A. Macular photocoagulation of human retina with a diode laser: a comparative histopathological study . Lasers Light Ophthalmol . 1990;3:11-28. 8. Balles MW, Puliafito CA, D'Amico DJ, Jacobsen JJ, Birngruber R. Semiconductor diode laser photocoagulation in retinal vascular disease . Ophthalmology . 1990;97:1553-1561.Crossref 9. Noyori K, Noyori S, Ohki R. Clinical trial of diode laser photocoagulator: preliminary report . Lasers Light Ophthalmol . 1990;3:81-87. 10. Wallow IHL, Sponsel WE, Stevens TS. Clinicopathologic correlation of diode laser burns in monkeys . Arch Ophthalmol . 1991;109:648-653.Crossref 11. Benner JD, Huang M, Ishigooka H, et al. A comparison of argon, krypton and diode binocular indirect ophthalmoscopic laser photocoagulation in the rabbit . Invest Ophthalmol Vis Sci . 1991;32:2764. 12. Avery RL, Repka MX, Green WR, D'Anna S, Goldberg MF. A comparative study of diode and argon laser indirect photocoagulation of primate retina . Invest Ophthalmol Vis Sci . 1991;32( (suppl) ):2766. 13. Jennings T, Fuller T, Vukich JA, et al. Trans-scleral retinal photocoagulation with an 810-nm semiconductor diode laser . Ophthalmic Surg . 1990;21:492-496. 14. Peyman GA, Naguib K, Gaasterland DE. Trans-scleral application of semi-conductor diode laser . Lasers Surg Med . 1990;10:569-575.Crossref 15. Okamoto S. Takahashi H, Fukado Y, Ozawa T. Laser diode application for trans-scleral photocoagulation . Lasers Light Ophthalmol . 1990;3:29-37. 16. Marshall J, Bird A. A comparative histopathologic study of argon and krypton laser irradiations of the human retina . Br J Ophthalmol . 1979;63:657-668.Crossref 17. Peyman GA, Li M, Yoneya S, Goldberg MF, Raichand M. Fundus photocoagulation with the argon and krypton lasers: a comparative study . Ophthalmic Surg . 1981;12:481-490. 18. Smiddy WE, Fine SL, Quigley AJ, Hohman RM, Addicks EM. Comparison of krypton and argon laser photocoagulation in primate retina . Arch Ophthalmol . 1984;102:1086-1092.Crossref 19. Blankenship GW, Gerke E, Batlle JF. Red krypton and blue-green argon laser diabetic panretinal photocoagulation . Graefes Arch Clin Exp Ophthalmol . 1989;227:364-368.Crossref 20. L'Esperance FA. The ocular histopathologic effect of krypton and argon laser radiation . Am J Ophthalmol . 1969;68:263-273. 21. Blankenship GW. Red krypton and bluegreen argon panretinal laser photocoagulation for proliferative diabetic retinopathy: a laboratory and clinical comparison . Trans Am Ophthalmol Soc . 1986;84:967-1003. 22. Macular Photocoagulation Study Group. Argon laser photocoagulation for senile macular degeneration: results of a randomized trial . Arch Ophthalmol . 1982;100:912-918.Crossref 23. Beetham WP, Aiello LM, Balodinos MC, Koncz L. Ruby laser photocoagulation of early diabetic retinopathy: a preliminary report . Trans Am Ophthalmol Soc . 1969;67:40-67. 24. Diabetic Retinopathy Study Research Group. Photocoagulation of proliferative diabetic retinopathy: the second report of the diabetic retinopathy study findings . Ophthalmology . 1978;85:82-105.Crossref 25. Early Treatment Diabetic Retinopathy Study Group. Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema: Early Treatment Diabetic Retinopathy Study report number 2 . Ophthalmology . 1987;94:761-774.Crossref 26. Campbell CJ, Ritter MC, Noyori KS, Swope GH, Koester CJ. The threshold of the retina to damage by laser energy . Arch Ophthalmol . 1966;76:437-442.Crossref 27. Peyman GA, Katoh N, Tawakol M, Khoobehi B, Federman J. Trans-scleral and intravitreal contact Nd: YAG laser application . Retina . 1987;7:190-197.Crossref 28. Geeraets WJ, Berry ER. Ocular special characteristics as related to hazards from lasers and other light sources . Am J Ophthalmol . 1968;66:15-20. 29. Birngruber R, Hillenkamp F, Gabel V-P. Theoretical investigations of laser thermal retinal injury . Health Phys . 1985;48:781-796.Crossref 30. Boettner EA, Wolter JR. Transmission of the ocular media . Invest Ophthalmol Vis Sci . 1962;1:776-783. 31. Balles MW, Puliafito CA, Kliman GH, El-Koumy HA, Reidy WT. Indocyanine green dye enhanced diode laser photocoagulation of subretinal neovascular membranes . Invest Ophthalmol Vis Sci . 1990;31( (suppl) ):282.

Journal

Archives of Ophthalmology – American Medical Association

Published: May 1, 1992

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