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Optic Neuritis and Ischemic Neuropathy: What We Thought We Already Knew

Optic Neuritis and Ischemic Neuropathy: What We Thought We Already Knew Abstract Inflammatory neuritis in the young and middle-aged and ischemic infarction in the late-midlife and older populations, are the most commonly encountered disorders of the optic nerves, glaucoma aside. For decades, these all too frequent clinical syndromes have seemed well defined in terms of chronology of visual loss, patterns of acuity and field depressions, efficacy of therapy, and associated diseases or risk factors. Two important studies published in this issue of the Archives raise questions about "What we thought we already knew." See also pp 1668 and 1673. Under the auspices of The National Institutes of Health (Bethesda, Md), 15 clinical centers began recruiting subjects for the Optic Neuritis Treatment Trial (ONTT) in 1988, in an attempt to settle the controversial issue of corticosteroid therapy. While awaiting the conclusions of this therapeutic assessment, the Optic Neuritis Study Group1 reports herein the baseline "clinical profile of acute optic neuritis." This study provides References 1. Optic Neuritis Study Group. The clinical profile of optic neuritis: experience of the optic neuritis treatment trial . Arch Ophthalmol . 1991;109:1673-1678.Crossref 2. Rizzo JF III, Lessell S. Optic neuritis and ischemic optic neuropathy: overlapping clinical profiles . Arch Ophthalmol . 1991;109:1668-1672.Crossref 3. Lepore FE. The origin of pain in optic neuritis: determinants of pain in 101 eyes with optic neuritis . Arch Neurol . 1991;48:748-749.Crossref 4. Parmley VC, Schiffman JS, Maitland CG, Miller NR, Dreyer RF, Hoyt WF. Does neuroretinitis rule out multiple sclerosis? Arch Neurol . 1987;44:1045.Crossref 5. Perkins GD, Rose FC. Optic Neuritis and Its Differential Diagnosis . Oxford, England: Oxford University Press; 1979:194-200. 6. Gould ES, Bird AC, Leaver PK, McDonald WI. Treatment of optic neuritis by retrobulbar injection of triamcinolone . BMJ . 1977;1:1495-1499.Crossref 7. Fleishman JA, Beck RW, Linares OA, Klein JW. Deficits in visual function after resolution of optic neuritis . Ophthalmology . 1987;94:1029-1034.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Optic Neuritis and Ischemic Neuropathy: What We Thought We Already Knew

Archives of Ophthalmology , Volume 109 (12) – Dec 1, 1991

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1991.01080120050023
Publisher site
See Article on Publisher Site

Abstract

Abstract Inflammatory neuritis in the young and middle-aged and ischemic infarction in the late-midlife and older populations, are the most commonly encountered disorders of the optic nerves, glaucoma aside. For decades, these all too frequent clinical syndromes have seemed well defined in terms of chronology of visual loss, patterns of acuity and field depressions, efficacy of therapy, and associated diseases or risk factors. Two important studies published in this issue of the Archives raise questions about "What we thought we already knew." See also pp 1668 and 1673. Under the auspices of The National Institutes of Health (Bethesda, Md), 15 clinical centers began recruiting subjects for the Optic Neuritis Treatment Trial (ONTT) in 1988, in an attempt to settle the controversial issue of corticosteroid therapy. While awaiting the conclusions of this therapeutic assessment, the Optic Neuritis Study Group1 reports herein the baseline "clinical profile of acute optic neuritis." This study provides References 1. Optic Neuritis Study Group. The clinical profile of optic neuritis: experience of the optic neuritis treatment trial . Arch Ophthalmol . 1991;109:1673-1678.Crossref 2. Rizzo JF III, Lessell S. Optic neuritis and ischemic optic neuropathy: overlapping clinical profiles . Arch Ophthalmol . 1991;109:1668-1672.Crossref 3. Lepore FE. The origin of pain in optic neuritis: determinants of pain in 101 eyes with optic neuritis . Arch Neurol . 1991;48:748-749.Crossref 4. Parmley VC, Schiffman JS, Maitland CG, Miller NR, Dreyer RF, Hoyt WF. Does neuroretinitis rule out multiple sclerosis? Arch Neurol . 1987;44:1045.Crossref 5. Perkins GD, Rose FC. Optic Neuritis and Its Differential Diagnosis . Oxford, England: Oxford University Press; 1979:194-200. 6. Gould ES, Bird AC, Leaver PK, McDonald WI. Treatment of optic neuritis by retrobulbar injection of triamcinolone . BMJ . 1977;1:1495-1499.Crossref 7. Fleishman JA, Beck RW, Linares OA, Klein JW. Deficits in visual function after resolution of optic neuritis . Ophthalmology . 1987;94:1029-1034.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1991

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