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Palladium 103 Ophthalmic Plaque Radiotherapy

Palladium 103 Ophthalmic Plaque Radiotherapy Abstract • We compared the ocular radiation distribution of palladium 103 (103Pd) vs iodine 125 (125I) ophthalmic plaques sewn to 12 human donor eyes. We then performed preoperative comparative simulations on the first seven patients to be treated with palladium 103 plaque therapy for choroidal melanoma. The in vitro experiment involved palladium 103 seeds placed into a Silastic seed holder, which was affixed into standard 14-mm gold eye plaques. Then the plaques were sewn onto 12 human donor eyes so as to approximate either the nasal (six eyes) or temporal (six eyes) equator. Three sets of two thermoluminescent dosimeters were used to quantify the amount of radiation delivered by the episcleral plaques. Thermoluminescent dosimeters were sewn to the sclera in three locations: on the center of the cornea, on the sclera beneath the macula, and at the equator in a position opposite the plaque. This experiment was then repeated with iodine 125 seeds and thermoluminescent dosimeters. After the plaques were adjusted to equalize their activity (plaque strength), the palladium 103 plaques were found to deliver less radiation to the three target points. Comparative clinical dosimetry also reflected this difference. Preoperative simulations comparing equal doses to the tumors' apex revealed that the palladium 103 ophthalmic plaques delivered more radiation to the tumor and less radiation to most normal ocular structures. References 1. Packer S, Rotman M. Radiotherapy of choroidal melanoma with iodine-125 . Ophthalmology . 1980;87:582-590.Crossref 2. Bosworth JL, Packer S, Rotman M, Ho TK, Finger PT. Choroidal melanoma: I-125 plaque therapy . Radiology . 1988;169:249-251.Crossref 3. Murphree AL, Rother C. Retinoblastoma . In: Ryan SJ, Schachat AP, eds. Retina . St Louis, Mo: Mosby—Year Book; 1989;1:539. 4. Shields JA, Augsburger JJ, Brady LW, Day JL. Cobalt plaque therapy of posterior uveal melanomas . Ophthalmology . 1982;89:1201-1207.Crossref 5. Anderson LL, Kwan HM, Ding IY. Clinical dosimetry with iodine-125 . In: George FW, ed. Modern Interstitial and Intracavitary Radiation in Cancer Management . New York, NY: Masson Publishing USA Inc; 1981:9-15. 6. Earle J, Kline RW, Robertson DM. Selection of iodine 125 for the collaborative ocular melanoma study . Arch Ophthalmol . 1987;105:763-764.Crossref 7. Meigooni AS, Sabnis S, Nath R. Dosimetry of palladium-103 brachytherapy source for permanent implants . Endocurietherapy Hyperthermia Oncol . 1990;6:107-109. 8. Chiu-Tsao ST, Anderson LL. Thermoluminescent dosimetry for Pd-103 seeds (model 200) in a solid water phantom . Med Phys . 1991;18:449-452.Crossref 9. Van Tuinen R, Arnold W, Elson H, Keene J, Kereiakes J. Radiation dose using thermoluminescent dosimetry . Appl Radiol . (May-June) 1973:27-29. 10. Chiu-Tsao ST, Anderson LL, Stabile L. TLD dosimetry for I-125 plaque. In: Program and abstracts of the World Congress on Medical Physics and Biomedical Engineering; August 6-13, 1988; San Antonio, Tex. Abstract 128. 11. Luxton G, Astrahan MA, Petrovich Z. Backscatter measurements from a single seed of I-125 for ophthalmic plaque dosimetry . Med Phys . 1988;15:397-400.Crossref 12. Astrahan MA, Luxton G, Jozsef G, Ligget PE, Petrovich Z. Optimization of I-125 ophthalmic plaque brachytherapy . Med Phys . 1990;17:1053-1057.Crossref 13. Finger PT, Packer S, Svitra PP, et al. Thermoradiotherapy of intraocular tumors . Arch Ophthalmol . 1985;103:1574-1578.Crossref 14. Finger PT, Packer S, Paglione RW, Gatz JF, Ho TK, Bosworth JL. Thermoradiotherapy of choroidal melanoma: clinical experience . Ophthalmology . 1989;96:1384-1388.Crossref 15. Finger PT, Ho TK, Fastenberg DM, et al. Intraocular radiation blocking . Invest Ophthalmol Vis Sci . 1990;31:1724-1730. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Palladium 103 Ophthalmic Plaque Radiotherapy

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1991.01080110148053
Publisher site
See Article on Publisher Site

Abstract

Abstract • We compared the ocular radiation distribution of palladium 103 (103Pd) vs iodine 125 (125I) ophthalmic plaques sewn to 12 human donor eyes. We then performed preoperative comparative simulations on the first seven patients to be treated with palladium 103 plaque therapy for choroidal melanoma. The in vitro experiment involved palladium 103 seeds placed into a Silastic seed holder, which was affixed into standard 14-mm gold eye plaques. Then the plaques were sewn onto 12 human donor eyes so as to approximate either the nasal (six eyes) or temporal (six eyes) equator. Three sets of two thermoluminescent dosimeters were used to quantify the amount of radiation delivered by the episcleral plaques. Thermoluminescent dosimeters were sewn to the sclera in three locations: on the center of the cornea, on the sclera beneath the macula, and at the equator in a position opposite the plaque. This experiment was then repeated with iodine 125 seeds and thermoluminescent dosimeters. After the plaques were adjusted to equalize their activity (plaque strength), the palladium 103 plaques were found to deliver less radiation to the three target points. Comparative clinical dosimetry also reflected this difference. Preoperative simulations comparing equal doses to the tumors' apex revealed that the palladium 103 ophthalmic plaques delivered more radiation to the tumor and less radiation to most normal ocular structures. References 1. Packer S, Rotman M. Radiotherapy of choroidal melanoma with iodine-125 . Ophthalmology . 1980;87:582-590.Crossref 2. Bosworth JL, Packer S, Rotman M, Ho TK, Finger PT. Choroidal melanoma: I-125 plaque therapy . Radiology . 1988;169:249-251.Crossref 3. Murphree AL, Rother C. Retinoblastoma . In: Ryan SJ, Schachat AP, eds. Retina . St Louis, Mo: Mosby—Year Book; 1989;1:539. 4. Shields JA, Augsburger JJ, Brady LW, Day JL. Cobalt plaque therapy of posterior uveal melanomas . Ophthalmology . 1982;89:1201-1207.Crossref 5. Anderson LL, Kwan HM, Ding IY. Clinical dosimetry with iodine-125 . In: George FW, ed. Modern Interstitial and Intracavitary Radiation in Cancer Management . New York, NY: Masson Publishing USA Inc; 1981:9-15. 6. Earle J, Kline RW, Robertson DM. Selection of iodine 125 for the collaborative ocular melanoma study . Arch Ophthalmol . 1987;105:763-764.Crossref 7. Meigooni AS, Sabnis S, Nath R. Dosimetry of palladium-103 brachytherapy source for permanent implants . Endocurietherapy Hyperthermia Oncol . 1990;6:107-109. 8. Chiu-Tsao ST, Anderson LL. Thermoluminescent dosimetry for Pd-103 seeds (model 200) in a solid water phantom . Med Phys . 1991;18:449-452.Crossref 9. Van Tuinen R, Arnold W, Elson H, Keene J, Kereiakes J. Radiation dose using thermoluminescent dosimetry . Appl Radiol . (May-June) 1973:27-29. 10. Chiu-Tsao ST, Anderson LL, Stabile L. TLD dosimetry for I-125 plaque. In: Program and abstracts of the World Congress on Medical Physics and Biomedical Engineering; August 6-13, 1988; San Antonio, Tex. Abstract 128. 11. Luxton G, Astrahan MA, Petrovich Z. Backscatter measurements from a single seed of I-125 for ophthalmic plaque dosimetry . Med Phys . 1988;15:397-400.Crossref 12. Astrahan MA, Luxton G, Jozsef G, Ligget PE, Petrovich Z. Optimization of I-125 ophthalmic plaque brachytherapy . Med Phys . 1990;17:1053-1057.Crossref 13. Finger PT, Packer S, Svitra PP, et al. Thermoradiotherapy of intraocular tumors . Arch Ophthalmol . 1985;103:1574-1578.Crossref 14. Finger PT, Packer S, Paglione RW, Gatz JF, Ho TK, Bosworth JL. Thermoradiotherapy of choroidal melanoma: clinical experience . Ophthalmology . 1989;96:1384-1388.Crossref 15. Finger PT, Ho TK, Fastenberg DM, et al. Intraocular radiation blocking . Invest Ophthalmol Vis Sci . 1990;31:1724-1730.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1991

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