Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Hypothesis Concerning Carbonic Anhydrase Treatment of Cystoid Macular Edema: Example With Epiretinal Membrane

Hypothesis Concerning Carbonic Anhydrase Treatment of Cystoid Macular Edema: Example With... Abstract Acetazolamide has been shown experimentally to facilitate the transport of water across the retinal pigment epithelium (RPE) from the subretinal space to the choroid.1 Cox et al2 found that carbonic anhydrase inhibitors were effective in promoting the absorption of intraretinal fluid in some cases of cystoid macular edema (CME), and they proposed that these drugs would be most effective in disorders in which the leakage came from the RPE rather than from the retinal vasculature. However, Fishman et al3 found them to be most effective against parafoveal retinal vascular edema in retinitis pigmentosa. There may be a simple explanation for these differing observations. Water is transported across the RPE in conjunction with a net movement of ions (particularly sodium chloride and bicarbonate), and the mammalian RPE membrane contains several active and facilitated transport systems that regulate traffic of those ions.4 These drugs are presumed to work References 1. Marmor MF, Maack T. Enhancement of retinal adhesion and subretinal fluid resorption by acetazolamide . Invest Ophthalmol Vis Sci . 1982;23:121-124. 2. Cox SN, Hay E, Bird AC. Treatment of chronic macular edema with acetazolamide . Arch Ophthalmol . 1988;106:1190-1195.Crossref 3. Fishman GA, Gilbert COT, Fiscella RG, Kimura AE, Jampol LM. Acetazolamide for treatment of chronic macular edema in retinitis pigmentosa . Arch Ophthalmol . 1989;107:1445-1452.Crossref 4. Hughes BA, Adorante JS, Miller SS, Lin H. Apical electrogenic NaHCO3 cotransport: a mechanism for HCO3 absorption across the retinal pigment epithelium . J Gen Physiol . 1989;24:125-150.Crossref 5. Steinsapir KD, Tripathi RC, Millard CB, Tripathi BJ, Ernest JT. Acetazolamide inhibits ocular gamma glutamyltransferase . Invest Ophthalmol Vis Sci . 1990;31( (suppl) ):140. 6. Yagoda AD, Walsh JB, Henkind P. Idiopathic preretinal macular gliosis . Int Ophthalmol Clin . 1981;21:107-118.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Hypothesis Concerning Carbonic Anhydrase Treatment of Cystoid Macular Edema: Example With Epiretinal Membrane

Marmor, Michael F.
Archives of Ophthalmology , Volume 108 (11) – Nov 1, 1990
Download PDF
2 pages

Loading next page...
 
/lp/american-medical-association/hypothesis-concerning-carbonic-anhydrase-treatment-of-cystoid-macular-0Npx91VKfU

References (6)

Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1990.01070130026013
Publisher site
See Article on Publisher Site

Abstract

Abstract Acetazolamide has been shown experimentally to facilitate the transport of water across the retinal pigment epithelium (RPE) from the subretinal space to the choroid.1 Cox et al2 found that carbonic anhydrase inhibitors were effective in promoting the absorption of intraretinal fluid in some cases of cystoid macular edema (CME), and they proposed that these drugs would be most effective in disorders in which the leakage came from the RPE rather than from the retinal vasculature. However, Fishman et al3 found them to be most effective against parafoveal retinal vascular edema in retinitis pigmentosa. There may be a simple explanation for these differing observations. Water is transported across the RPE in conjunction with a net movement of ions (particularly sodium chloride and bicarbonate), and the mammalian RPE membrane contains several active and facilitated transport systems that regulate traffic of those ions.4 These drugs are presumed to work References 1. Marmor MF, Maack T. Enhancement of retinal adhesion and subretinal fluid resorption by acetazolamide . Invest Ophthalmol Vis Sci . 1982;23:121-124. 2. Cox SN, Hay E, Bird AC. Treatment of chronic macular edema with acetazolamide . Arch Ophthalmol . 1988;106:1190-1195.Crossref 3. Fishman GA, Gilbert COT, Fiscella RG, Kimura AE, Jampol LM. Acetazolamide for treatment of chronic macular edema in retinitis pigmentosa . Arch Ophthalmol . 1989;107:1445-1452.Crossref 4. Hughes BA, Adorante JS, Miller SS, Lin H. Apical electrogenic NaHCO3 cotransport: a mechanism for HCO3 absorption across the retinal pigment epithelium . J Gen Physiol . 1989;24:125-150.Crossref 5. Steinsapir KD, Tripathi RC, Millard CB, Tripathi BJ, Ernest JT. Acetazolamide inhibits ocular gamma glutamyltransferase . Invest Ophthalmol Vis Sci . 1990;31( (suppl) ):140. 6. Yagoda AD, Walsh JB, Henkind P. Idiopathic preretinal macular gliosis . Int Ophthalmol Clin . 1981;21:107-118.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Nov 1, 1990

There are no references for this article.