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A Spindle-Cell Myoepithelioma of the Lacrimal Gland

A Spindle-Cell Myoepithelioma of the Lacrimal Gland Abstract • A middle-aged woman developed unilateral, painless proptosis that increased slowly over 1 year. A clinical diagnosis of pleomorphic adenoma of the lacrimal gland was supported by computed tomographic scanning and the tumor was excised. On histological examination the tumor proved to be a benign, myxoid myoepithelioma of spindle-cell type. Although occasionally seen in the salivary glands, to our knowledge, this tumor has not previously been described in the lacrimal gland. References 1. Cho KJ, Kim YI. Monomorphic adenomas of the salivary glands: a clinicopathologic study of 12 cases with immunohistochemical observation . Pathol Res Pract . 1989;184:614-620.Crossref 2. Dardick I, van Nostrand AWP. Morphogenesis of salivary gland tumors: a prerequisite to improving classification . Pathol Annu . 1987;22:1-53. 3. Reese AB. The treatment of expanding lesions of the orbit . Am J Ophthalmol . 1956;41:3-11. 4. Henderson JW, Farrow GM. Orbital Tumors . Philadelphia, Pa: WB Saunders Co; 1973:409-443. 5. Font RL, Gamel JW. Epithelial tumors of the lacrimal gland: an analysis of 265 cases . In: Jakobiec FA, ed. Ocular and Adnexal Tumors . New York, NY: Aesculapius Publishers Inc; 1978:787-805. 6. Stewart WB, Krohel GB, Wright JE. Lacrimal gland and fossa lesions . Ophthalmology . 1979;86:886-895.Crossref 7. Ni C, Cheng SC, Dryja TP, Cheng TY. Lacrimal gland tumors: a clinicopathological analysis of 160 cases . Int Ophthalmol Clin . 1982;22:99-120.Crossref 8. Rootman J. Diseases of the Orbit: A Multidisciplinary Approach . Philadelphia, Pa: JB Lippincott Co; 1988:384-405. 9. Shields CL, Shields JA, Eagle RC, Rathwell JP. Clinicopathologic review of 142 cases of lacrimal gland lesions . Ophthalmology . 1989;96:431-435.Crossref 10. Iwamoto T, Jakobiec FA. A comparative ultrastructural study of the normal lacrimal gland and its epithelial tumors . Hum Pathol . 1982;13:236-262.Crossref 11. Dardick I, Rippstein P, Skimming L, Boivin M, Dairkee SH. Immunohistochemistry and ultrastructure of myoepithelium and modified myoepithelium of the ducts of human major salivary glands: histogenetic implications for salivary gland tumors . Oral Surg . 1987;64:703-715.Crossref 12. Batsakis JG. Myoepithelioma . Ann Otol Rhinol Laryngol . 1985;94:523-524. 13. Palmer RM. The identification of myoepithelial cells in human salivary glands: a review and comparison of light microscopical methods . J Oral Pathol . 1986;15:221-229.Crossref 14. Dardick I, Thomas MJ, van Nostrand AWP. Myoepithelioma—new concepts of histology and classification: a light and electron microscopic study . Ultrastruct Pathol . 1989;13:187-224.Crossref 15. Luna MA, Mackay B, Gomez-Araujo J. Myoepithelioma of the palate . Cancer . 1973;32:1429-1435.Crossref 16. Barnes L, Appel BN, Perez H, El-Attar AM. Myoepitheliomas of the head and neck: case report and review . J Surg Oncol . 1985;28:21-28.Crossref 17. Mori M, Ninomiya T, Okada Y, Tsukitani K. Myoepitheliomas and myoepithelial adenomas of salivary gland origin: immunohistochemical evaluation of filament proteins, S-100 α and β glial fibrillary acidic protein, neuron-specific enolase, and lactoferrin . Pathol Res Pract . 1989;184:168-178.Crossref 18. Sciubba JJ, Brannon RB. Myoepithelioma of salivary glands: report of 23 cases . Cancer . 1982;49:562-572.Crossref 19. Zarbo RJ, Regezi JA, Hatfield JS, et al. Immunoreactive glial fibrillary acidic protein in normal and neoplastic salivary glands: a combined immunohistochemical and immunoblot study . Surg Pathol . 1988;1:55-63. 20. Gray MH, Rosenberg AE, Dickersin GR, Bhan AK. Glial fibrillary acidic protein and keratin expression by benign and malignant nerve sheath tumors . Hum Pathol . 1989;20:1089-1096.Crossref 21. Ashton N. Epithelial tumors of the lacrimal gland . Mod Probl Ophthalmol . 1975;14:306-323. 22. Collina G, Eusebi V, Carasoli PT. Pleomorphic adenoma with lymph-node metastases: report of two cases . Pathol Res Pract . 1989;184:188-193.Crossref 23. Biggs SL, Font RL. Oncocytic lesions of the caruncle and other ocular adnexa . Arch Ophthalmol . 1977;95:474-478.Crossref 24. Peel RL, Gnepp DR. Diseases of the salivary glands . In: Barnes L, ed. Surgical Pathology of the Head and Neck . New York, NY: Marcel Dekker Inc; 1985:533-645. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

A Spindle-Cell Myoepithelioma of the Lacrimal Gland

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References (31)

Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1990.01070100091041
Publisher site
See Article on Publisher Site

Abstract

Abstract • A middle-aged woman developed unilateral, painless proptosis that increased slowly over 1 year. A clinical diagnosis of pleomorphic adenoma of the lacrimal gland was supported by computed tomographic scanning and the tumor was excised. On histological examination the tumor proved to be a benign, myxoid myoepithelioma of spindle-cell type. Although occasionally seen in the salivary glands, to our knowledge, this tumor has not previously been described in the lacrimal gland. References 1. Cho KJ, Kim YI. Monomorphic adenomas of the salivary glands: a clinicopathologic study of 12 cases with immunohistochemical observation . Pathol Res Pract . 1989;184:614-620.Crossref 2. Dardick I, van Nostrand AWP. Morphogenesis of salivary gland tumors: a prerequisite to improving classification . Pathol Annu . 1987;22:1-53. 3. Reese AB. The treatment of expanding lesions of the orbit . Am J Ophthalmol . 1956;41:3-11. 4. Henderson JW, Farrow GM. Orbital Tumors . Philadelphia, Pa: WB Saunders Co; 1973:409-443. 5. Font RL, Gamel JW. Epithelial tumors of the lacrimal gland: an analysis of 265 cases . In: Jakobiec FA, ed. Ocular and Adnexal Tumors . New York, NY: Aesculapius Publishers Inc; 1978:787-805. 6. Stewart WB, Krohel GB, Wright JE. Lacrimal gland and fossa lesions . Ophthalmology . 1979;86:886-895.Crossref 7. Ni C, Cheng SC, Dryja TP, Cheng TY. Lacrimal gland tumors: a clinicopathological analysis of 160 cases . Int Ophthalmol Clin . 1982;22:99-120.Crossref 8. Rootman J. Diseases of the Orbit: A Multidisciplinary Approach . Philadelphia, Pa: JB Lippincott Co; 1988:384-405. 9. Shields CL, Shields JA, Eagle RC, Rathwell JP. Clinicopathologic review of 142 cases of lacrimal gland lesions . Ophthalmology . 1989;96:431-435.Crossref 10. Iwamoto T, Jakobiec FA. A comparative ultrastructural study of the normal lacrimal gland and its epithelial tumors . Hum Pathol . 1982;13:236-262.Crossref 11. Dardick I, Rippstein P, Skimming L, Boivin M, Dairkee SH. Immunohistochemistry and ultrastructure of myoepithelium and modified myoepithelium of the ducts of human major salivary glands: histogenetic implications for salivary gland tumors . Oral Surg . 1987;64:703-715.Crossref 12. Batsakis JG. Myoepithelioma . Ann Otol Rhinol Laryngol . 1985;94:523-524. 13. Palmer RM. The identification of myoepithelial cells in human salivary glands: a review and comparison of light microscopical methods . J Oral Pathol . 1986;15:221-229.Crossref 14. Dardick I, Thomas MJ, van Nostrand AWP. Myoepithelioma—new concepts of histology and classification: a light and electron microscopic study . Ultrastruct Pathol . 1989;13:187-224.Crossref 15. Luna MA, Mackay B, Gomez-Araujo J. Myoepithelioma of the palate . Cancer . 1973;32:1429-1435.Crossref 16. Barnes L, Appel BN, Perez H, El-Attar AM. Myoepitheliomas of the head and neck: case report and review . J Surg Oncol . 1985;28:21-28.Crossref 17. Mori M, Ninomiya T, Okada Y, Tsukitani K. Myoepitheliomas and myoepithelial adenomas of salivary gland origin: immunohistochemical evaluation of filament proteins, S-100 α and β glial fibrillary acidic protein, neuron-specific enolase, and lactoferrin . Pathol Res Pract . 1989;184:168-178.Crossref 18. Sciubba JJ, Brannon RB. Myoepithelioma of salivary glands: report of 23 cases . Cancer . 1982;49:562-572.Crossref 19. Zarbo RJ, Regezi JA, Hatfield JS, et al. Immunoreactive glial fibrillary acidic protein in normal and neoplastic salivary glands: a combined immunohistochemical and immunoblot study . Surg Pathol . 1988;1:55-63. 20. Gray MH, Rosenberg AE, Dickersin GR, Bhan AK. Glial fibrillary acidic protein and keratin expression by benign and malignant nerve sheath tumors . Hum Pathol . 1989;20:1089-1096.Crossref 21. Ashton N. Epithelial tumors of the lacrimal gland . Mod Probl Ophthalmol . 1975;14:306-323. 22. Collina G, Eusebi V, Carasoli PT. Pleomorphic adenoma with lymph-node metastases: report of two cases . Pathol Res Pract . 1989;184:188-193.Crossref 23. Biggs SL, Font RL. Oncocytic lesions of the caruncle and other ocular adnexa . Arch Ophthalmol . 1977;95:474-478.Crossref 24. Peel RL, Gnepp DR. Diseases of the salivary glands . In: Barnes L, ed. Surgical Pathology of the Head and Neck . New York, NY: Marcel Dekker Inc; 1985:533-645.

Journal

Archives of Ophthalmology – American Medical Association

Published: Aug 1, 1990

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