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Bilateral Peripheral Corneal Edema After Cefaclor Therapy

Bilateral Peripheral Corneal Edema After Cefaclor Therapy Abstract Drug eruptions following therapy with antibiotics are commonly encountered in clinical practice. Many of these are considered secondary to circulating immune complexes (Gel and Coombs'1(p1351) type III hypersensitivity). I examined a patient who developed bilateral limbal hyperemia with peripheral corneal stromal and epithelial edema concurrent with a fever and rash after receiving oral cefaclor. Report of a Case. —A 45-year-old white man was referred to the Eye Institute, Milwaukee, Wis, with bilateral keratoconjunctivitis. He reported that 9 days previously, he had noted a painful swelling of his right preauricular region. Infectious parotitis was diagnosed at a walk-in clinic, and the patient was begun on treatment with oral cefaclor. After 2 days, a rash developed abruptly, beginning on the palms and spreading to diffusely involve the entire body. The cefaclor was discontinued; however, fever and eye pain developed that night. An ophthalmologist diagnosed conjunctivitis, and gentamicin drops were prescribed without References 1. AMA Drug Evaluations . 6th ed. Chicago, Ill: American Medical Association; 1986:1337-1394. 2. Baum JL, Bierstock SR. Peripheral corneal infiltrates following intravenous injection of diatrizoate meglumine . Am J Ophthalmol . 1978;85:613-614. 3. Mondino BJ. Inflammatory diseases of the peripheral cornea . Ophthalmology . 1988;95:463-472.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Bilateral Peripheral Corneal Edema After Cefaclor Therapy

Archives of Ophthalmology , Volume 108 (2) – Feb 1, 1990

Bilateral Peripheral Corneal Edema After Cefaclor Therapy

Abstract

Abstract Drug eruptions following therapy with antibiotics are commonly encountered in clinical practice. Many of these are considered secondary to circulating immune complexes (Gel and Coombs'1(p1351) type III hypersensitivity). I examined a patient who developed bilateral limbal hyperemia with peripheral corneal stromal and epithelial edema concurrent with a fever and rash after receiving oral cefaclor. Report of a Case. —A 45-year-old white man was referred to the Eye Institute,...
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1990.01070040027014
Publisher site
See Article on Publisher Site

Abstract

Abstract Drug eruptions following therapy with antibiotics are commonly encountered in clinical practice. Many of these are considered secondary to circulating immune complexes (Gel and Coombs'1(p1351) type III hypersensitivity). I examined a patient who developed bilateral limbal hyperemia with peripheral corneal stromal and epithelial edema concurrent with a fever and rash after receiving oral cefaclor. Report of a Case. —A 45-year-old white man was referred to the Eye Institute, Milwaukee, Wis, with bilateral keratoconjunctivitis. He reported that 9 days previously, he had noted a painful swelling of his right preauricular region. Infectious parotitis was diagnosed at a walk-in clinic, and the patient was begun on treatment with oral cefaclor. After 2 days, a rash developed abruptly, beginning on the palms and spreading to diffusely involve the entire body. The cefaclor was discontinued; however, fever and eye pain developed that night. An ophthalmologist diagnosed conjunctivitis, and gentamicin drops were prescribed without References 1. AMA Drug Evaluations . 6th ed. Chicago, Ill: American Medical Association; 1986:1337-1394. 2. Baum JL, Bierstock SR. Peripheral corneal infiltrates following intravenous injection of diatrizoate meglumine . Am J Ophthalmol . 1978;85:613-614. 3. Mondino BJ. Inflammatory diseases of the peripheral cornea . Ophthalmology . 1988;95:463-472.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1990

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