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Obstruction of the Trabecular Meshwork by Retinal Rod Outer Segments

Obstruction of the Trabecular Meshwork by Retinal Rod Outer Segments Abstract • Rod outer segments (ROS) have been described in the anterior chamber of patients with the Schwartz syndrome (retinal detachment, uveitis, and glaucoma). The effect of ROS on aqueous outflow was studied by intracameral injection of ROS in human eye bank eyes and in vivo in the cat. Injection of 108 ROS in eye bank eyes (n = 8) caused a 19.7% decrease in outflow facility. This was significantly different than in control eyes (n = 8), where the outflow facility decreased 5.2%. Injection of intracameral ROS in the cat resulted in a rise in intraocular pressure (IOP) from a baseline of 19.7 ± 1.3 mm Hg to a peak of 30.0 ± 0.7 mm Hg at 24 hours. By 48 hours, IOP returned to baseline. Control injection did not cause a change in IOP. Electron microscopy of the cat trabecular meshwork revealed occlusion of the intratrabecular spaces by ROS with little evidence of inflammatory activity. References 1. Schwartz A, Chronic open-angle glaucoma secondary to rhegmatogenous retinal detachment . Am J Ophthalmol 1973;75:205-211. 2. Phelps C, Burton TC: Glaucoma and retinal detachment . Arch Ophthalmol 1977;95:418-422.Crossref 3. Matsuo N, Takabatake M, Ueno H, et al: Photoreceptor outer segments in the aqueous humor in rhegmatogenous retinal detachment . Am J Ophthalmol 1986;101:673-679. 4. Papermaster DS, Dreyer WJ: Rhodopsin content in the outer segment membranes of bovine and frog retinal rods . Biochemistry 1974;13:2438-2444.Crossref 5. Grant WM: Further studies on facility of flow through the trabecular meshwork . Arch Ophthalmol 1958;60:523-533.Crossref 6. Barany EH: Simultaneous measurement of changing intraocular pressure and outflow facility in the vervet monkey by constant pressure infusion . Invest Ophthalmol Vis Sci 1964;3:135-143. 7. Gaasterland DE, Pederson JE, MacLellan HM, et al: Rhesus monkey aqueous humor composition and a primate ocular perfusate . Invest Ophthalmol Vis Sci 1979;18:1139-1150. 8. Linnér E: Intra-ocular pressure in retinal detachment . Acta Ophthalmol 1966;84( (suppl) ):101-106. 9. Davidorf FH: Retinal pigment epithelial glaucoma . Ophthalmol Dig 1976;38:11-16. 10. Lambrou FH, Campbell DG, Aiken D, et al: The production and mechanism of ghost cell glaucoma in the cat and primate . Invest Ophthalmol Vis Sci 1983;26:893-897. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Obstruction of the Trabecular Meshwork by Retinal Rod Outer Segments

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1989.01070010760041
Publisher site
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Abstract

Abstract • Rod outer segments (ROS) have been described in the anterior chamber of patients with the Schwartz syndrome (retinal detachment, uveitis, and glaucoma). The effect of ROS on aqueous outflow was studied by intracameral injection of ROS in human eye bank eyes and in vivo in the cat. Injection of 108 ROS in eye bank eyes (n = 8) caused a 19.7% decrease in outflow facility. This was significantly different than in control eyes (n = 8), where the outflow facility decreased 5.2%. Injection of intracameral ROS in the cat resulted in a rise in intraocular pressure (IOP) from a baseline of 19.7 ± 1.3 mm Hg to a peak of 30.0 ± 0.7 mm Hg at 24 hours. By 48 hours, IOP returned to baseline. Control injection did not cause a change in IOP. Electron microscopy of the cat trabecular meshwork revealed occlusion of the intratrabecular spaces by ROS with little evidence of inflammatory activity. References 1. Schwartz A, Chronic open-angle glaucoma secondary to rhegmatogenous retinal detachment . Am J Ophthalmol 1973;75:205-211. 2. Phelps C, Burton TC: Glaucoma and retinal detachment . Arch Ophthalmol 1977;95:418-422.Crossref 3. Matsuo N, Takabatake M, Ueno H, et al: Photoreceptor outer segments in the aqueous humor in rhegmatogenous retinal detachment . Am J Ophthalmol 1986;101:673-679. 4. Papermaster DS, Dreyer WJ: Rhodopsin content in the outer segment membranes of bovine and frog retinal rods . Biochemistry 1974;13:2438-2444.Crossref 5. Grant WM: Further studies on facility of flow through the trabecular meshwork . Arch Ophthalmol 1958;60:523-533.Crossref 6. Barany EH: Simultaneous measurement of changing intraocular pressure and outflow facility in the vervet monkey by constant pressure infusion . Invest Ophthalmol Vis Sci 1964;3:135-143. 7. Gaasterland DE, Pederson JE, MacLellan HM, et al: Rhesus monkey aqueous humor composition and a primate ocular perfusate . Invest Ophthalmol Vis Sci 1979;18:1139-1150. 8. Linnér E: Intra-ocular pressure in retinal detachment . Acta Ophthalmol 1966;84( (suppl) ):101-106. 9. Davidorf FH: Retinal pigment epithelial glaucoma . Ophthalmol Dig 1976;38:11-16. 10. Lambrou FH, Campbell DG, Aiken D, et al: The production and mechanism of ghost cell glaucoma in the cat and primate . Invest Ophthalmol Vis Sci 1983;26:893-897.

Journal

Archives of Ophthalmology – American Medical Association

Published: May 1, 1989

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