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Drug Binding of Ophthalmic Viscoelastic Agents

Drug Binding of Ophthalmic Viscoelastic Agents Abstract • When viscoelastic agents that contain hyaluronate sodium are used during anterior segment surgical procedures, it is common for some of the material to remain intraocularly after the surgery is completed. A variety of drugs, used intracamerally or topically following surgery, are also present. These drugs may be bound to the polyanionic hyaluronate molecule. This occurrence may cause drug alterations in therapeutic effectiveness, pharmacokinetics, and toxicity. To investigate the possibility for drug-viscoelastic agent adsorption, in vitro drug-binding studies were performed on three commercial viscoelastic agents; undiluted aliquots of Amvisc, Healon, or Viscoat were mixed with radiolabeled d-threo-chloramphenicol, dexamethasone, l-epinephrine, or pilocarpine hydrochloride, placed in dialysis membranes, and dialyzed for 24 hours against an isotonic phosphate buffer. The calculated drug binding by a viscoelastic agent ranged from 0% to 1.5%. These extremely low values for in vitro drug uptake by viscoelastic agents made it unlikely that any significant drug-viscoelastic agent interaction would occur in the postoperative eye. References 1. Alvere P: Intravitreal injection of high molecular weight hyaluronic acid in retinal detachment surgery . Acta Ophthalmol 1971;49:975-977. 2. Meyer K: Chemical structure of hyaluronic acid . FASEB J 1958;17:1075-1077. 3. Laurent TC: Structure of hyaluronic acid , in Balazs EA (ed): Chemistry and Molecular Biology of the Intercellular Matrix . Orlando, Fla, Academic Press Inc, 1970, pp 703-732. 4. Pape LG, Balazs EA: The use of Nahyaluronate in human anterior segment eye surgery . Ophthalmology 1980;87:699-705.Crossref 5. Miller D, Stegmann R: Use of sodium hyaluronate in anterior segment eye surgery . Am Intra-Ocular Implant Soc J 1980;6:13-15.Crossref 6. Polack FM, Demong T, Santaella H: Sodium hyaluronate (Healon®) in keratoplasty and IOL implantation . Ophthalmology 1981;88:425-431.Crossref 7. Alpar JJ: Sodium hyaluronate (Healon®) in glaucoma filtering procedures . Ophthalmic Surg 1986;17:724-730. 8. Stegmann R, Miller D: Use of sodium hyaluronate in severe penetrating ocular trauma . Ann Ophthalmol 1986;18:9-13. 9. Leith MM, Loftus SA, Kuo JW, et al: Comparison of the properties of AMVISC and Healon . J Cataract Refract Surg 1987;13:534-536.Crossref 10. Freeman JM, Gettlfinger TC: Maintaining pupillary dilatation during lens implant surgery . Am Intra-Ocular Implant Soc J 1981;7:172-173.Crossref 11. Grehn F: Intraocular thymoxamine for miosis during surgery . Am J Ophthalmol 1987;103:709-711. 12. Gills JP: Prevention of endophthalmitis by intraocular solution filtration and antibiotics . Am Intra-Ocular Implant Soc J 1985;11:185-186.Crossref 13. Mannis MJ, Sweet E, Landers MB, et al: Uses of thrombin in ocular surgery . Arch Ophthalmol 1988;106:251-253.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Drug Binding of Ophthalmic Viscoelastic Agents

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1989.01070010267034
Publisher site
See Article on Publisher Site

Abstract

Abstract • When viscoelastic agents that contain hyaluronate sodium are used during anterior segment surgical procedures, it is common for some of the material to remain intraocularly after the surgery is completed. A variety of drugs, used intracamerally or topically following surgery, are also present. These drugs may be bound to the polyanionic hyaluronate molecule. This occurrence may cause drug alterations in therapeutic effectiveness, pharmacokinetics, and toxicity. To investigate the possibility for drug-viscoelastic agent adsorption, in vitro drug-binding studies were performed on three commercial viscoelastic agents; undiluted aliquots of Amvisc, Healon, or Viscoat were mixed with radiolabeled d-threo-chloramphenicol, dexamethasone, l-epinephrine, or pilocarpine hydrochloride, placed in dialysis membranes, and dialyzed for 24 hours against an isotonic phosphate buffer. The calculated drug binding by a viscoelastic agent ranged from 0% to 1.5%. These extremely low values for in vitro drug uptake by viscoelastic agents made it unlikely that any significant drug-viscoelastic agent interaction would occur in the postoperative eye. References 1. Alvere P: Intravitreal injection of high molecular weight hyaluronic acid in retinal detachment surgery . Acta Ophthalmol 1971;49:975-977. 2. Meyer K: Chemical structure of hyaluronic acid . FASEB J 1958;17:1075-1077. 3. Laurent TC: Structure of hyaluronic acid , in Balazs EA (ed): Chemistry and Molecular Biology of the Intercellular Matrix . Orlando, Fla, Academic Press Inc, 1970, pp 703-732. 4. Pape LG, Balazs EA: The use of Nahyaluronate in human anterior segment eye surgery . Ophthalmology 1980;87:699-705.Crossref 5. Miller D, Stegmann R: Use of sodium hyaluronate in anterior segment eye surgery . Am Intra-Ocular Implant Soc J 1980;6:13-15.Crossref 6. Polack FM, Demong T, Santaella H: Sodium hyaluronate (Healon®) in keratoplasty and IOL implantation . Ophthalmology 1981;88:425-431.Crossref 7. Alpar JJ: Sodium hyaluronate (Healon®) in glaucoma filtering procedures . Ophthalmic Surg 1986;17:724-730. 8. Stegmann R, Miller D: Use of sodium hyaluronate in severe penetrating ocular trauma . Ann Ophthalmol 1986;18:9-13. 9. Leith MM, Loftus SA, Kuo JW, et al: Comparison of the properties of AMVISC and Healon . J Cataract Refract Surg 1987;13:534-536.Crossref 10. Freeman JM, Gettlfinger TC: Maintaining pupillary dilatation during lens implant surgery . Am Intra-Ocular Implant Soc J 1981;7:172-173.Crossref 11. Grehn F: Intraocular thymoxamine for miosis during surgery . Am J Ophthalmol 1987;103:709-711. 12. Gills JP: Prevention of endophthalmitis by intraocular solution filtration and antibiotics . Am Intra-Ocular Implant Soc J 1985;11:185-186.Crossref 13. Mannis MJ, Sweet E, Landers MB, et al: Uses of thrombin in ocular surgery . Arch Ophthalmol 1988;106:251-253.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Feb 1, 1989

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