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Calcific Band Keratopathy After Intraocular Chondroitin Sulfate

Calcific Band Keratopathy After Intraocular Chondroitin Sulfate Abstract • A patient developed an acute onset of pseudophakic bullous keratopathy and a diffuse, gray, subepithelial corneal deposit ten days following surgery during which sodium chondroitin sulfate was used. The deposit, identified histologically as calcium, was noted throughout Bowman's layer. The absence of chronic pathologic features in the posterior cornea eliminated Fuchs' endothelial dystrophy as the cause of the acute corneal decompensation. This histopathologic confirmation of calcium deposition with one formulation of chondroitin sulfate, combined with similar conclusions from previous case reports, stimulated the reformulation of the product, which has been shown to be useful in clinical practice. References 1. Duke-Elder S (ed): System of Ophthalmology. London, Henry Kimpton, 1965, vol 8: Diseases of the Outer Eye , p 770. 2. Henriksen E: Primary calcareous corneal dystrophy: A case report . Acta Ophthalmol 1982;60:759-764.Crossref 3. Grossniklaus HE, Wood WJ, Bargeron CB, et al: Sulfur and calcific keratopathy associated with retinal detachment surgery and vitrectomy . Ophthalmology 1986;93:260-264.Crossref 4. Stark AJ, Proctor J: Atypical band-shape calcific keratopathy with keratocyte changes . Br J Ophthalmol 1982;66:309-316.Crossref 5. O'Connor GR: Calcific band keratopathy . Trans Am Ophthalmol Soc 1972;70:58-81. 6. Cursino JW, Fine BS: A histologic study of calcific and noncalcific band keratopathies . Am J Ophthalmol 1976;82:395-404. 7. Freddo TF, Leibowitz HM: Bilateral acute corneal calcification . Ophthalmology 1985;92:537-542.Crossref 8. Bloomfield SE, David DS, Rubin AL: Acute corneal calcification . Ann Ophthalmol 1978;10:355-360. 9. Lemp MA, Ralph RA: Rapid development of band keratopathy in dry eyes . Am J Ophthalmol 1977;83:657-659. 10. Coffman MR, Mann PM: Corneal subepithelial deposits after use of sodium chondroitin . Am J Ophthalmol 1986;102:279-280.Crossref 11. Nevyas A: Rapid onset of band keratopathy following use of Viscoat . Curr Can Ophthalmic Pract 1986;4:80-81. 12. Ullman S, Lichtenstein SB, Heerlein K: Corneal opacities secondary to Viscoat . J Cataract Refract Surg 1986;12:489-492.Crossref 13. Bancroft JD, Cook HC: Manual of Histological Techniques . New York, Churchill Livingstone, 1984, pp 244. 14. Binder PS, Worthen DM, Wickham MG, et al: Corneal endothelial damage associated with phacoemulsification . Am J Ophthalmol 1976;82:48-54. 15. Kaufman HE, Katz JI: Endothelial damage from intraocular lens insertion . Invest Ophthalmol Vis Sci 1976;15:996-1000. 16. Vastine DW, Binder PS: Stripping of Descemet's membrane associated with intraocular lens implantation . Arch Ophthalmol 1983;101:1042-1045.Crossref 17. Edelhauser HF, Van Horn DL, Schultz RO, et al: Comparative toxicity of intraocular irrigation solutions on the corneal endothelium . Am J Ophthalmol 1976;81:473-481. 18. Maurice DM, McCulley JP, Schartz BD: The use of cultured endothelium in keratoplasty . Vision Res 1981;21:173-174.Crossref 19. Soll DB, Harrison SE, Arturi FC, et al: Evaluation and protection of corneal endothelium . Am Intra-ocular Implant Soc J 1980;6:239-242.Crossref 20. Kaufman HE, Varnell ED, Kaufman S, et al: K-Sol corneal preservation . Am J Ophthalmol 1985;100:299-304. 21. Bourne WM, Johnson DH, Campbell RJ: The ultrastructure of Descemet's membrane . Arch Ophthalmol 1982;100:1952-1955.Crossref 22. Hoopes PC: Sodium hyaluronate (Healon) in anterior segment surgery: A review and a new use in extracapsular surgery . Am Intra-ocular Implant Soc J 1982;8:148-154.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Calcific Band Keratopathy After Intraocular Chondroitin Sulfate

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References (24)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1987.01060090101037
Publisher site
See Article on Publisher Site

Abstract

Abstract • A patient developed an acute onset of pseudophakic bullous keratopathy and a diffuse, gray, subepithelial corneal deposit ten days following surgery during which sodium chondroitin sulfate was used. The deposit, identified histologically as calcium, was noted throughout Bowman's layer. The absence of chronic pathologic features in the posterior cornea eliminated Fuchs' endothelial dystrophy as the cause of the acute corneal decompensation. This histopathologic confirmation of calcium deposition with one formulation of chondroitin sulfate, combined with similar conclusions from previous case reports, stimulated the reformulation of the product, which has been shown to be useful in clinical practice. References 1. Duke-Elder S (ed): System of Ophthalmology. London, Henry Kimpton, 1965, vol 8: Diseases of the Outer Eye , p 770. 2. Henriksen E: Primary calcareous corneal dystrophy: A case report . Acta Ophthalmol 1982;60:759-764.Crossref 3. Grossniklaus HE, Wood WJ, Bargeron CB, et al: Sulfur and calcific keratopathy associated with retinal detachment surgery and vitrectomy . Ophthalmology 1986;93:260-264.Crossref 4. Stark AJ, Proctor J: Atypical band-shape calcific keratopathy with keratocyte changes . Br J Ophthalmol 1982;66:309-316.Crossref 5. O'Connor GR: Calcific band keratopathy . Trans Am Ophthalmol Soc 1972;70:58-81. 6. Cursino JW, Fine BS: A histologic study of calcific and noncalcific band keratopathies . Am J Ophthalmol 1976;82:395-404. 7. Freddo TF, Leibowitz HM: Bilateral acute corneal calcification . Ophthalmology 1985;92:537-542.Crossref 8. Bloomfield SE, David DS, Rubin AL: Acute corneal calcification . Ann Ophthalmol 1978;10:355-360. 9. Lemp MA, Ralph RA: Rapid development of band keratopathy in dry eyes . Am J Ophthalmol 1977;83:657-659. 10. Coffman MR, Mann PM: Corneal subepithelial deposits after use of sodium chondroitin . Am J Ophthalmol 1986;102:279-280.Crossref 11. Nevyas A: Rapid onset of band keratopathy following use of Viscoat . Curr Can Ophthalmic Pract 1986;4:80-81. 12. Ullman S, Lichtenstein SB, Heerlein K: Corneal opacities secondary to Viscoat . J Cataract Refract Surg 1986;12:489-492.Crossref 13. Bancroft JD, Cook HC: Manual of Histological Techniques . New York, Churchill Livingstone, 1984, pp 244. 14. Binder PS, Worthen DM, Wickham MG, et al: Corneal endothelial damage associated with phacoemulsification . Am J Ophthalmol 1976;82:48-54. 15. Kaufman HE, Katz JI: Endothelial damage from intraocular lens insertion . Invest Ophthalmol Vis Sci 1976;15:996-1000. 16. Vastine DW, Binder PS: Stripping of Descemet's membrane associated with intraocular lens implantation . Arch Ophthalmol 1983;101:1042-1045.Crossref 17. Edelhauser HF, Van Horn DL, Schultz RO, et al: Comparative toxicity of intraocular irrigation solutions on the corneal endothelium . Am J Ophthalmol 1976;81:473-481. 18. Maurice DM, McCulley JP, Schartz BD: The use of cultured endothelium in keratoplasty . Vision Res 1981;21:173-174.Crossref 19. Soll DB, Harrison SE, Arturi FC, et al: Evaluation and protection of corneal endothelium . Am Intra-ocular Implant Soc J 1980;6:239-242.Crossref 20. Kaufman HE, Varnell ED, Kaufman S, et al: K-Sol corneal preservation . Am J Ophthalmol 1985;100:299-304. 21. Bourne WM, Johnson DH, Campbell RJ: The ultrastructure of Descemet's membrane . Arch Ophthalmol 1982;100:1952-1955.Crossref 22. Hoopes PC: Sodium hyaluronate (Healon) in anterior segment surgery: A review and a new use in extracapsular surgery . Am Intra-ocular Implant Soc J 1982;8:148-154.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1987

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