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Improvement of the Blood-Retinal Barrier Induced by Bendazac Lysine: Preliminary Clinical Observation in Insulin-Dependent Diabetics

Improvement of the Blood-Retinal Barrier Induced by Bendazac Lysine: Preliminary Clinical... Abstract To the Editor. —Diabetes predominantly affects the microvascular system of the eye, and during the early stages of the disease, even in the absence of ophthalmoscopic signs of retinopathy, a breakdown of the blood-retinal barrier (BRB) may be observed.1,2 This has been shown by vitreous fluorophotometry, which has proved to be a useful clinical method to test the effects of drugs on the BRB.Bendazac lysine has been reported to be effective in inhibiting protein denaturation,3 thereby reducing the necrotic, inflammatory, and degenerative response of tissues in selected instances. For this reason it was thought that it might be protective in diabetes.We have measured the effect of bendazac lysine in insulin-dependent diabetic patients who showed mild background retinopathy and breakdown of the BRB.We examined 12 consecutive consenting adult patients affected by insulin-dependent diabetes mellitus who exhibited abnormal leakage of fluorescein into the vitreous gel in both References 1. Cunha-Vaz JG, Abreu JRF, Campos AJ, et al: Early breakdown of the blood-retinal barrier in diabetes . Br J Ophthalmol 1976;59:649-656.Crossref 2. Nuzzi G, Vanelli M, Venturini I, et al: Vitreous fluorophotometry in juvenile diabetics after oral fluorescein . Arch Ophthalmol 1986;104:1630-1631.Crossref 3. Silvestrini B, Catanese B, Lisciani R: A biochemical basis of the antiinflammatory activity of bendazac (af 983) , in Bartelli A, Houck JC (eds): Inflammation, Biochemistry and Drug Interaction . Amsterdam, Excerpta Medica, 1969, pp 283-288. 4. Kirk RE: Experimental Design , ed 2. Monterey, Calif, Brooks/Cole Publishing Co, 1982, pp 112-114. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Improvement of the Blood-Retinal Barrier Induced by Bendazac Lysine: Preliminary Clinical Observation in Insulin-Dependent Diabetics

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1987.01060090023007
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —Diabetes predominantly affects the microvascular system of the eye, and during the early stages of the disease, even in the absence of ophthalmoscopic signs of retinopathy, a breakdown of the blood-retinal barrier (BRB) may be observed.1,2 This has been shown by vitreous fluorophotometry, which has proved to be a useful clinical method to test the effects of drugs on the BRB.Bendazac lysine has been reported to be effective in inhibiting protein denaturation,3 thereby reducing the necrotic, inflammatory, and degenerative response of tissues in selected instances. For this reason it was thought that it might be protective in diabetes.We have measured the effect of bendazac lysine in insulin-dependent diabetic patients who showed mild background retinopathy and breakdown of the BRB.We examined 12 consecutive consenting adult patients affected by insulin-dependent diabetes mellitus who exhibited abnormal leakage of fluorescein into the vitreous gel in both References 1. Cunha-Vaz JG, Abreu JRF, Campos AJ, et al: Early breakdown of the blood-retinal barrier in diabetes . Br J Ophthalmol 1976;59:649-656.Crossref 2. Nuzzi G, Vanelli M, Venturini I, et al: Vitreous fluorophotometry in juvenile diabetics after oral fluorescein . Arch Ophthalmol 1986;104:1630-1631.Crossref 3. Silvestrini B, Catanese B, Lisciani R: A biochemical basis of the antiinflammatory activity of bendazac (af 983) , in Bartelli A, Houck JC (eds): Inflammation, Biochemistry and Drug Interaction . Amsterdam, Excerpta Medica, 1969, pp 283-288. 4. Kirk RE: Experimental Design , ed 2. Monterey, Calif, Brooks/Cole Publishing Co, 1982, pp 112-114.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1987

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