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Refractive Keratoplasty in Monkeys Using Intracorneal Lenses of Various Refractive Indexes

Refractive Keratoplasty in Monkeys Using Intracorneal Lenses of Various Refractive Indexes Abstract • The refractive power of the cornea can be altered with an intracorneal lens when it is inserted within a freehand lamellar-pocket incision. The effectiveness of the implant in altering the refractive power of the cornea depends on the refractive index of the intracorneal lens, since little change in the anterior corneal curvature occurs. Thirteen nonhuman primate eyes received intracorneal lenses made of synthetic polymers with refractive indexes ranging from 1.3686 to 1.633. The lidofilcon-B hydrogel (refractive index, 1.3686) lenses created no significant alteration in the refractive power of the cornea. The polymethylmethacrylate (refractive index, 1.4900D) and polysulfone (refractive index, 1.633) lenses created a predictable and significant alteration of corneal power that increased with each implant with a successively higher refractive index. The polymethylmethacrylate lens created a refractive alteration that was approximately 31% of the lens power in air. The polysulfone lens created a corneal power alteration that was approximately 40% of the lens power in air. References 1. Ainslie D: The surgical correction of refractive errors by keratomileusis and keratophakia . Ann Ophthalmol 1976;8:349-367. 2. Swinger CA, Barraquer JI: Keratophakia and keratomileusis: Clinical results . Ophthalmology 1981;88:709-715.Crossref 3. Taylor DM, Stern AL, Romanchuk KG, et al: Keratophakia: Clinical evaluation . Ophthalmology 1981;88:1141-1150.Crossref 4. McCarey BE, Andrews DM: Refractive keratoplasty with intrastromal hydrogel lenticular implants . Invest Ophthalmol Vis Sci 1981;21:107-115. 5. McCarey BE, Andrews DM, Hatchell DL, et al: Hydrogel implants for refractive keratoplasty: Corneal morphology . Curr Eye Res 1982/ 83;2:29-38.Crossref 6. Binder PS, Deg JK, Zavala EY, et al: Hydrogel keratophakia in nonhuman primates . Curr Eye Res 1981/82;1:535-542.Crossref 7. Werblin TP, Blaydes JE, Fryczkowski AW, et al: Stability of hydrogel intracorneal implants in nonhuman primates . CLAO J 1983;9:157-161. 8. McDonald MB, Koenig SB, Friedlander MH, et al: Alloplastic epikeratophakia for the correction of aphakia . Ophthalmic Surg 1983;14:65-69. 9. Koenig SB, Hamano T, Yamaguchi T, et al: Refractive keratoplasty with hydrogel implants in primates . Ophthalmic Surg 1984;15:225-229. 10. McCarey BE, van Rij G, Beekhuis WH, et al: Hydrogel keratophakia: A freehand pocket dissection in the monkey model . Br J Ophthalmol 1986;70:187-191.Crossref 11. Watsky MA, McCarey BE, Beekhuis WH: Predicting refractive alterations with hydrogel keratophakia . Invest Ophthalmol Vis Sci 1985;26:240-243. 12. Beekhuis WH, McCarey BE, van Rij G, et al: Hydrogel keratophakia: A microkeratome dissection in the monkey model . Br J Ophthalmol 1986;70:192-198.Crossref 13. Choyce DP: The correction of refractive errors with polysulfone corneal inlays: A new frontier to be explored? Trans Ophthal Soc UK 1985;104:332-342. 14. Kirkness CM, Steele AD, Gardner A: Polysulfone corneal inlays. Adverse Reactions: A preliminary report . Trans Ophthalmol Soc UK 1985;104:343-350. 15. Lane SL, Cameron JD, Lindstrom RL, et al: Polysulfone corneal lenses . J Cataract Refract Surg 1986;12:50-60.Crossref 16. Climenhaga H, McCarey BE: Biocompatibility of polysulfone intracorneal lenses in the cat model . Invest Ophthalmol Vis Sci 1986;27( (suppl) ):14. 17. Ratner BD: Biomedical applications of hydrogels: Review and critical appraisal , in Williams DF (ed): Biocompatibility of Clinical Implant Materials . Boca Raton, Fla, CRC press Inc, 1981, vol 2, pp 145-175. 18. Beekhuis WH, McCarey BE, van Rij G, et al: Complications of hydrogel intracorneal lenses in monkeys. Arch Ophthalmol, in press. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Refractive Keratoplasty in Monkeys Using Intracorneal Lenses of Various Refractive Indexes

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References (21)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1987.01060010129044
Publisher site
See Article on Publisher Site

Abstract

Abstract • The refractive power of the cornea can be altered with an intracorneal lens when it is inserted within a freehand lamellar-pocket incision. The effectiveness of the implant in altering the refractive power of the cornea depends on the refractive index of the intracorneal lens, since little change in the anterior corneal curvature occurs. Thirteen nonhuman primate eyes received intracorneal lenses made of synthetic polymers with refractive indexes ranging from 1.3686 to 1.633. The lidofilcon-B hydrogel (refractive index, 1.3686) lenses created no significant alteration in the refractive power of the cornea. The polymethylmethacrylate (refractive index, 1.4900D) and polysulfone (refractive index, 1.633) lenses created a predictable and significant alteration of corneal power that increased with each implant with a successively higher refractive index. The polymethylmethacrylate lens created a refractive alteration that was approximately 31% of the lens power in air. The polysulfone lens created a corneal power alteration that was approximately 40% of the lens power in air. References 1. Ainslie D: The surgical correction of refractive errors by keratomileusis and keratophakia . Ann Ophthalmol 1976;8:349-367. 2. Swinger CA, Barraquer JI: Keratophakia and keratomileusis: Clinical results . Ophthalmology 1981;88:709-715.Crossref 3. Taylor DM, Stern AL, Romanchuk KG, et al: Keratophakia: Clinical evaluation . Ophthalmology 1981;88:1141-1150.Crossref 4. McCarey BE, Andrews DM: Refractive keratoplasty with intrastromal hydrogel lenticular implants . Invest Ophthalmol Vis Sci 1981;21:107-115. 5. McCarey BE, Andrews DM, Hatchell DL, et al: Hydrogel implants for refractive keratoplasty: Corneal morphology . Curr Eye Res 1982/ 83;2:29-38.Crossref 6. Binder PS, Deg JK, Zavala EY, et al: Hydrogel keratophakia in nonhuman primates . Curr Eye Res 1981/82;1:535-542.Crossref 7. Werblin TP, Blaydes JE, Fryczkowski AW, et al: Stability of hydrogel intracorneal implants in nonhuman primates . CLAO J 1983;9:157-161. 8. McDonald MB, Koenig SB, Friedlander MH, et al: Alloplastic epikeratophakia for the correction of aphakia . Ophthalmic Surg 1983;14:65-69. 9. Koenig SB, Hamano T, Yamaguchi T, et al: Refractive keratoplasty with hydrogel implants in primates . Ophthalmic Surg 1984;15:225-229. 10. McCarey BE, van Rij G, Beekhuis WH, et al: Hydrogel keratophakia: A freehand pocket dissection in the monkey model . Br J Ophthalmol 1986;70:187-191.Crossref 11. Watsky MA, McCarey BE, Beekhuis WH: Predicting refractive alterations with hydrogel keratophakia . Invest Ophthalmol Vis Sci 1985;26:240-243. 12. Beekhuis WH, McCarey BE, van Rij G, et al: Hydrogel keratophakia: A microkeratome dissection in the monkey model . Br J Ophthalmol 1986;70:192-198.Crossref 13. Choyce DP: The correction of refractive errors with polysulfone corneal inlays: A new frontier to be explored? Trans Ophthal Soc UK 1985;104:332-342. 14. Kirkness CM, Steele AD, Gardner A: Polysulfone corneal inlays. Adverse Reactions: A preliminary report . Trans Ophthalmol Soc UK 1985;104:343-350. 15. Lane SL, Cameron JD, Lindstrom RL, et al: Polysulfone corneal lenses . J Cataract Refract Surg 1986;12:50-60.Crossref 16. Climenhaga H, McCarey BE: Biocompatibility of polysulfone intracorneal lenses in the cat model . Invest Ophthalmol Vis Sci 1986;27( (suppl) ):14. 17. Ratner BD: Biomedical applications of hydrogels: Review and critical appraisal , in Williams DF (ed): Biocompatibility of Clinical Implant Materials . Boca Raton, Fla, CRC press Inc, 1981, vol 2, pp 145-175. 18. Beekhuis WH, McCarey BE, van Rij G, et al: Complications of hydrogel intracorneal lenses in monkeys. Arch Ophthalmol, in press.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jan 1, 1987

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