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Massive Retinal Gliosis: A Reactive Proliferation of Müller Cells

Massive Retinal Gliosis: A Reactive Proliferation of Müller Cells Abstract • Both Müller cells and astrocytes have been implicated in the dispute over the histogenesis of massive retinal gliosis. We studied three cases of massive retinal gliosis by light and electron microscopy and immunocytochemistry. Spindle fibrillary glial cells were joined by zonulae adherentes resembling those of the external limiting membrane of the retina. Furthermore, these cells produced a continuous basement membrane around an extracellular space filled with fine filaments, which was highly suggestive of vitreous cavity. In the proliferating cells, immunoperoxidase technique disclosed the presence of carbonic anhydrase isoenzyme C, characteristically found only in Müller cells. The glial cells in the preretinal membrane away from the gliotic nodule showed similar characteristics. We concluded that both the nodule of massive retinal gliosis and the associated preretinal glial membrane resulted from the proliferation and migration of Müller cells. References 1. Von Hippel E: Über diffuse Gliose der Netzhout und ihre Beziehungen zu der Angiomatosis retinae . Graefes Arch Clin Exp Ophthalmol 1918;95:173-183.Crossref 2. Friedenwald JS: Massive gliosis of the retina , in Crisp WH, Finnoff WC (eds): Contributions of Ophthalmic Science: Dedicated to Dr Edward Jackson . Menasha, Wis, George Banta, 1926, pp 23-28. 3. Yanoff M, Zimmerman LE, Davis RL: Massive gliosis of the retina . Int Ophthalmol Clin 1971;11:211-229. 4. Duke-Elder S, Dobree JH: General considerations: Diseases of the retina , in Duke-Elder (ed): System of Ophthalmology . St Louis, CV Mosby Co, 1967, vol 10, chap 1, pp 3-41. 5. Lee WR: Degenerative and other disorders of the retina and choroid , in Garner A, Klintworth GF (eds): Pathobiology of Ocular Disease: A Dynamic Approach . New York, Marcel Dekker Inc, 1982, chap 47, pp 1321-1350. 6. Shields JA: Glial tumors of the retina and optic disc , in Shields JA (ed): Diagnosis and Management of Intraocular Tumors . St Louis, CV Mosby Co, 1983, chap 19, pp 569-594. 7. Berger B, Peyman GA, Juarez C, et al: Massive retinal gliosis simulating choroidal melanoma . Can J Ophthalmol 1979;14:285-290. 8. Peyman GA, Sanders DR: Advances in Uveal Surgery, Vitreous Surgery, and the Treatment of Endophthalmitis . East Norwalk, Conn, Appleton-Century-Crofts, 1975, pp 51-52. 9. Sternberger LA: The unlabeled antibody peroxidase-antiperoxidase (PAP) method , in Immunocytochemistry , ed 2. New York, John Wiley & Sons Inc, 1979, chap 5, pp 104-169. 10. Molnar ML, Stefansson K, Marton LS, et al: Distribution of S100 protein and glial fibrillary acidic protein in normal and gliotic human retina . Exp Eye Res 1984;38:27-34.Crossref 11. Jakobiec FA, Brodie SE, Haik B, et al: Giant cell astrocytoma of the retina: A tumor of possible Müller cell origin . Ophthalmology 1983;90:1565-1576.Crossref 12. Eisenfeld AJ, Bunt-Milam AH, Sarthy PV: Müller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina . Invest Ophthalmol Vis Sci 1984;25:1321-1328. 13. Musser GL, Rosen S: Localization of carbonic anhydrase activity in the vertebrate retina . Exp Eye Res 1973;15:105-109.Crossref 14. Ghandour MS, Langley OK, Vincendon G, et al: Double labeling immunohistochemical technique provides evidence of the specificity of glial cell markers . J Histochem Cytochem 1979;27:1634-1637.Crossref 15. Linser P, Moscona AA: Carbonic anhydrase C in the neural retina: Transition from generalized to glia-specific cell localization during embryonic development . Proc Natl Acad Sci USA 1981;78:7190-7194.Crossref 16. Kumpulainen T, Dahl D, Korhonen LK, et al: Immunolabeling of carbonic anhydrase isoenzyme C and glial fibrillary acidic protein in paraffin-embedded tissue sections of human brain and retina . J Histochem Cytochem 1983;31:879-886.Crossref 17. Erickson PA, Fisher SK, Anderson DH, et al: Retinal detachment in the cat: The outer nuclear and outer plexiform layers . Invest Ophthalmol Vis Sci 1983;24:927-942. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Massive Retinal Gliosis: A Reactive Proliferation of Müller Cells

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1986.01050210137041
Publisher site
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Abstract

Abstract • Both Müller cells and astrocytes have been implicated in the dispute over the histogenesis of massive retinal gliosis. We studied three cases of massive retinal gliosis by light and electron microscopy and immunocytochemistry. Spindle fibrillary glial cells were joined by zonulae adherentes resembling those of the external limiting membrane of the retina. Furthermore, these cells produced a continuous basement membrane around an extracellular space filled with fine filaments, which was highly suggestive of vitreous cavity. In the proliferating cells, immunoperoxidase technique disclosed the presence of carbonic anhydrase isoenzyme C, characteristically found only in Müller cells. The glial cells in the preretinal membrane away from the gliotic nodule showed similar characteristics. We concluded that both the nodule of massive retinal gliosis and the associated preretinal glial membrane resulted from the proliferation and migration of Müller cells. References 1. Von Hippel E: Über diffuse Gliose der Netzhout und ihre Beziehungen zu der Angiomatosis retinae . Graefes Arch Clin Exp Ophthalmol 1918;95:173-183.Crossref 2. Friedenwald JS: Massive gliosis of the retina , in Crisp WH, Finnoff WC (eds): Contributions of Ophthalmic Science: Dedicated to Dr Edward Jackson . Menasha, Wis, George Banta, 1926, pp 23-28. 3. Yanoff M, Zimmerman LE, Davis RL: Massive gliosis of the retina . Int Ophthalmol Clin 1971;11:211-229. 4. Duke-Elder S, Dobree JH: General considerations: Diseases of the retina , in Duke-Elder (ed): System of Ophthalmology . St Louis, CV Mosby Co, 1967, vol 10, chap 1, pp 3-41. 5. Lee WR: Degenerative and other disorders of the retina and choroid , in Garner A, Klintworth GF (eds): Pathobiology of Ocular Disease: A Dynamic Approach . New York, Marcel Dekker Inc, 1982, chap 47, pp 1321-1350. 6. Shields JA: Glial tumors of the retina and optic disc , in Shields JA (ed): Diagnosis and Management of Intraocular Tumors . St Louis, CV Mosby Co, 1983, chap 19, pp 569-594. 7. Berger B, Peyman GA, Juarez C, et al: Massive retinal gliosis simulating choroidal melanoma . Can J Ophthalmol 1979;14:285-290. 8. Peyman GA, Sanders DR: Advances in Uveal Surgery, Vitreous Surgery, and the Treatment of Endophthalmitis . East Norwalk, Conn, Appleton-Century-Crofts, 1975, pp 51-52. 9. Sternberger LA: The unlabeled antibody peroxidase-antiperoxidase (PAP) method , in Immunocytochemistry , ed 2. New York, John Wiley & Sons Inc, 1979, chap 5, pp 104-169. 10. Molnar ML, Stefansson K, Marton LS, et al: Distribution of S100 protein and glial fibrillary acidic protein in normal and gliotic human retina . Exp Eye Res 1984;38:27-34.Crossref 11. Jakobiec FA, Brodie SE, Haik B, et al: Giant cell astrocytoma of the retina: A tumor of possible Müller cell origin . Ophthalmology 1983;90:1565-1576.Crossref 12. Eisenfeld AJ, Bunt-Milam AH, Sarthy PV: Müller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina . Invest Ophthalmol Vis Sci 1984;25:1321-1328. 13. Musser GL, Rosen S: Localization of carbonic anhydrase activity in the vertebrate retina . Exp Eye Res 1973;15:105-109.Crossref 14. Ghandour MS, Langley OK, Vincendon G, et al: Double labeling immunohistochemical technique provides evidence of the specificity of glial cell markers . J Histochem Cytochem 1979;27:1634-1637.Crossref 15. Linser P, Moscona AA: Carbonic anhydrase C in the neural retina: Transition from generalized to glia-specific cell localization during embryonic development . Proc Natl Acad Sci USA 1981;78:7190-7194.Crossref 16. Kumpulainen T, Dahl D, Korhonen LK, et al: Immunolabeling of carbonic anhydrase isoenzyme C and glial fibrillary acidic protein in paraffin-embedded tissue sections of human brain and retina . J Histochem Cytochem 1983;31:879-886.Crossref 17. Erickson PA, Fisher SK, Anderson DH, et al: Retinal detachment in the cat: The outer nuclear and outer plexiform layers . Invest Ophthalmol Vis Sci 1983;24:927-942.

Journal

Archives of Ophthalmology – American Medical Association

Published: Sep 1, 1986

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