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Pigmentary Dispersion Syndrome and Pigmentary Glaucoma: A Prospective Study of the Natural History

Pigmentary Dispersion Syndrome and Pigmentary Glaucoma: A Prospective Study of the Natural History Abstract • The natural evolution of pigmentary dispersion syndrome and pigmentary glaucoma was studied in 55 patients for six to 43 months (mean, 27 months). Active dispersion of pigment was observed in 45 eyes in 31 patients and was associated with worsening of glaucoma in 32 eyes. Dispersion of pigment was defined as active when there was increase in iris transillumination, increase in corneal pigmentation, or appearance of pigment granules on the surface of the lens in the pupil. There were no differences in the frequency of active dispersion of pigment and worsening of glaucoma comparing patients aged less than 44, 45 to 64, and 65 or more years. This study demonstrates that active dispersion of pigment is clinically detectable, is correlated with elevation of intraocular pressure, and continues to occur in older patients. References 1. Sugar HS, Barbour FA: Pigmentary glaucoma: A rare clinical entity . Am J Ophthalmol 1949;32:90-92. 2. Lichter PR, Shaffer RN: Diagnostic and prognostic signs in pigmentary glaucoma . Trans Am Acad Ophthalmol Otolaryngol 1970;74:984-998. 3. Campbell DG: Pigmentary dispersion and glaucoma: A new theory . Arch Ophthalmol 1979; 97:1667-1672.Crossref 4. Ritch R: Nonprogressive low-tension glaucoma with pigmentary dispersion . Am J Ophthalmol 1982;94:190-196. 5. Speakman JS: Pigmentary dispersion . Br J Ophthalmol 1981;65:249-251.Crossref 6. Kampik A, Green R, Quigley HA, et al: Scanning and transmission electron microscopic studies of two cases of pigment dispersion syndrome . Am J Ophthalmol 1981;91:573-587. 7. Emiru VP: Response to mydriatics in the African . Br J Ophthalmol 1971;55:538-543.Crossref 8. Calhoun FP Jr: Pigmentary glaucoma and its relation to Krukenberg's spindles . Am J Ophthalmol 1953;36:1398-1415. 9. Lichter PR: Pigmentary glaucoma: Current concepts . Trans Am Acad Ophthalmol Otolaryngol 1974;78:309-313. 10. Becker B, Podos SM: Krukenberg's spindles and primary open-angle glaucoma . Arch Ophthalmol 1966;76:635-639.Crossref 11. Bellows AR, Jocson VL, Sears ML: Iris pigment granule obstruction of the aqueous outflow channel in enucleated monkey eyes. Read before the Association for Research in Vision and Ophthalmology National Meeting, April 28, 1974. 12. Grant WM: Experimental aqueous perfusion in enucleated human eyes . Arch Ophthalmol 1963;69:783-801.Crossref 13. Epstein DL, Boger WP III, Grant WM: Phenylephrine provocative testing in the pigmentary dispersion syndrome . Am J Ophthalmol 1978;85:43-50. 14. Richardson TM: Pigmentary glaucoma , in Ritch R, Shields MR (eds): The Secondary Glaucomas . St Louis, CV Mosby Co, 1982, pp 84-98. 15. Fine BS, Yanoff M, Scheie HG: Pigmentary 'glaucoma': A histologic study . Trans Am Acad Ophthalmol Otolarynyol 1974;78:314-325. 16. Epstein DL: Pigment dispersion and pigmentary glaucoma , in Chandler PA, Grant WM (eds): Glaucoma , ed 2. Philadelphia, Lea & Febiger, 1979, pp 122-129. 17. Richardson TM, Hutchinson BT, Grant WM: The outflow tract in pigmentary glaucoma . Arch Ophthalmol 1977;95:1015-1025.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Pigmentary Dispersion Syndrome and Pigmentary Glaucoma: A Prospective Study of the Natural History

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1986.01050140065021
Publisher site
See Article on Publisher Site

Abstract

Abstract • The natural evolution of pigmentary dispersion syndrome and pigmentary glaucoma was studied in 55 patients for six to 43 months (mean, 27 months). Active dispersion of pigment was observed in 45 eyes in 31 patients and was associated with worsening of glaucoma in 32 eyes. Dispersion of pigment was defined as active when there was increase in iris transillumination, increase in corneal pigmentation, or appearance of pigment granules on the surface of the lens in the pupil. There were no differences in the frequency of active dispersion of pigment and worsening of glaucoma comparing patients aged less than 44, 45 to 64, and 65 or more years. This study demonstrates that active dispersion of pigment is clinically detectable, is correlated with elevation of intraocular pressure, and continues to occur in older patients. References 1. Sugar HS, Barbour FA: Pigmentary glaucoma: A rare clinical entity . Am J Ophthalmol 1949;32:90-92. 2. Lichter PR, Shaffer RN: Diagnostic and prognostic signs in pigmentary glaucoma . Trans Am Acad Ophthalmol Otolaryngol 1970;74:984-998. 3. Campbell DG: Pigmentary dispersion and glaucoma: A new theory . Arch Ophthalmol 1979; 97:1667-1672.Crossref 4. Ritch R: Nonprogressive low-tension glaucoma with pigmentary dispersion . Am J Ophthalmol 1982;94:190-196. 5. Speakman JS: Pigmentary dispersion . Br J Ophthalmol 1981;65:249-251.Crossref 6. Kampik A, Green R, Quigley HA, et al: Scanning and transmission electron microscopic studies of two cases of pigment dispersion syndrome . Am J Ophthalmol 1981;91:573-587. 7. Emiru VP: Response to mydriatics in the African . Br J Ophthalmol 1971;55:538-543.Crossref 8. Calhoun FP Jr: Pigmentary glaucoma and its relation to Krukenberg's spindles . Am J Ophthalmol 1953;36:1398-1415. 9. Lichter PR: Pigmentary glaucoma: Current concepts . Trans Am Acad Ophthalmol Otolaryngol 1974;78:309-313. 10. Becker B, Podos SM: Krukenberg's spindles and primary open-angle glaucoma . Arch Ophthalmol 1966;76:635-639.Crossref 11. Bellows AR, Jocson VL, Sears ML: Iris pigment granule obstruction of the aqueous outflow channel in enucleated monkey eyes. Read before the Association for Research in Vision and Ophthalmology National Meeting, April 28, 1974. 12. Grant WM: Experimental aqueous perfusion in enucleated human eyes . Arch Ophthalmol 1963;69:783-801.Crossref 13. Epstein DL, Boger WP III, Grant WM: Phenylephrine provocative testing in the pigmentary dispersion syndrome . Am J Ophthalmol 1978;85:43-50. 14. Richardson TM: Pigmentary glaucoma , in Ritch R, Shields MR (eds): The Secondary Glaucomas . St Louis, CV Mosby Co, 1982, pp 84-98. 15. Fine BS, Yanoff M, Scheie HG: Pigmentary 'glaucoma': A histologic study . Trans Am Acad Ophthalmol Otolarynyol 1974;78:314-325. 16. Epstein DL: Pigment dispersion and pigmentary glaucoma , in Chandler PA, Grant WM (eds): Glaucoma , ed 2. Philadelphia, Lea & Febiger, 1979, pp 122-129. 17. Richardson TM, Hutchinson BT, Grant WM: The outflow tract in pigmentary glaucoma . Arch Ophthalmol 1977;95:1015-1025.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1986

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