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Short-term Effect of Argon Laser Trabeculoplasty in Monkeys

Short-term Effect of Argon Laser Trabeculoplasty in Monkeys Abstract • We performed argon laser trabeculoplasty (ALT) in four cynomolgus monkeys and evaluated the morphologic changes in the trabecular meshwork one hour and 14 hours following the laser treatment. One hour after ALT, disruption of the trabecular beams and coagulative necrosis of the tissue were evident. Fragmented cells and fibrillar tissue debris were found in the trabecular spaces, accumulating in the juxtacanalicular region. This might explain the elevation of intraocular pressure seen immediately following ALT in some glaucomatous patients. Also, many trabecular endothelial cells were rounded up, displaying different stages of leaving the beams; these cells were actively phagocytic. Such stimulation of trabecular meshwork cells with subsequent removal of tissue debris might explain the temporary nature of elevation of intraocular pressure following ALT. References 1. Wise JB, Witter SC: Argon laser therapy for open-angle glaucoma . Arch Ophthalmol 1979; 97:319-322.Crossref 2. Wise JB: Long-term control of adult openangle glaucoma by argon laser treatment . Ophthalmology 1981;88:197-202.Crossref 3. Thomas JV, Simmons RJ, Belcher CD III: Argon laser trabeculoplasty in the presurgical glaucoma patient . Ophthalmology 1982;89:187-197.Crossref 4. Schwartz AL, Whitten ME, Bleiman B, et al: Argon laser trabecular surgery in uncontrolled phakic open-angle glaucoma . Ophthalmology 1981;88:203-212.Crossref 5. Wilensky JT, Jampol LM: Laser therapy for open-angle glaucoma . Ophthalmology 1981; 88:213-217.Crossref 6. Thomas JV, Simmons RJ, Belcher CD: Complications of argon laser trabeculoplasty . Glaucoma 1982;4:50-52. 7. Wickham MG, Worthen DM: Long-term follow-up of patients treated with the argon laser trabeculoplasty procedure . Ophthalmology 1979; 86:495-503.Crossref 8. Hoskins MD, Hetherington J, Minckler DS, et al: Complications of laser trabeculoplasty . Ophthalmology 1983;90:796-799.Crossref 9. Melamed S, Pei J, Puliafito C, et al: Q-switched neodymium-YAG laser trabeculopuncture in monkeys . Arch Ophthalmol 1985;103:129-133.Crossref 10. Greenidge KG, Rodrigues MM, Spaeth GL, et al: Acute intraocular pressure elevation after argon laser trabeculoplasty and iridectomy: A clinicopathologic study . Ophthalmic Surg 1984; 15:105-110. 11. Krupin T, Kolker AE, Kass MA, et al: Intraocular pressure the day of argon laser trabeculoplasty in primary open-angle glaucoma . Ophthalmology 1984;91:361-365.Crossref 12. Rodrigues MM, Spaeth GL, Donohoo P: Electron microscopy of argon laser therapy in phakic open-angle glaucoma . Ophthalmology 1982;89:198-210.Crossref 13. Koss ML, March WF, Nordquist RE, et al: Acute intraocular pressure elevation produced by argon laser trabeculoplasty in the cynomolgus monkey . Arch Ophthalmol 1984;102:1699-1703.Crossref 14. Van Buskirk EM, Pond V, Rosenquist RC, et al: Argon laser trabeculoplasty: Studies on mechanism of action . Ophthalmology 1984;91: 1005-1010.Crossref 15. Masuyama Y: Histopathological study of anterior chamber angle after laser trabeculoplasty . Nippon Ganka Gakkai Zasshi 1984; 88:1007-1020. 16. Freddo TF, Pei JH, Bassett-Chu S, et al: Morphological and physiological effects of experimental pigmentary dispersion in monkey eyes . Invest Ophthalmol Vis Sci 1985;24( (suppl) ):85. 17. Johnson DH, Richardson TM, Epstein DL: Trabecular meshwork phagocytosis: Long-term response . Invest Ophthalmol Vis Sci 1985;24 ( (suppl) ):136. 18. Rohen JW: Why is intraocular pressure elevated in chronic simple glaucoma? Anatomical considerations . Ophthalmology 1983;90:758-765.Crossref 19. Rohen JW, Witmer R: Electron microscopic studies on the trabecular meshwork in glaucoma simplex . Graefes Arch Clin Exp Ophthalmol 1972;83:251-266.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Short-term Effect of Argon Laser Trabeculoplasty in Monkeys

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References (24)

Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1985.01050100122032
Publisher site
See Article on Publisher Site

Abstract

Abstract • We performed argon laser trabeculoplasty (ALT) in four cynomolgus monkeys and evaluated the morphologic changes in the trabecular meshwork one hour and 14 hours following the laser treatment. One hour after ALT, disruption of the trabecular beams and coagulative necrosis of the tissue were evident. Fragmented cells and fibrillar tissue debris were found in the trabecular spaces, accumulating in the juxtacanalicular region. This might explain the elevation of intraocular pressure seen immediately following ALT in some glaucomatous patients. Also, many trabecular endothelial cells were rounded up, displaying different stages of leaving the beams; these cells were actively phagocytic. Such stimulation of trabecular meshwork cells with subsequent removal of tissue debris might explain the temporary nature of elevation of intraocular pressure following ALT. References 1. Wise JB, Witter SC: Argon laser therapy for open-angle glaucoma . Arch Ophthalmol 1979; 97:319-322.Crossref 2. Wise JB: Long-term control of adult openangle glaucoma by argon laser treatment . Ophthalmology 1981;88:197-202.Crossref 3. Thomas JV, Simmons RJ, Belcher CD III: Argon laser trabeculoplasty in the presurgical glaucoma patient . Ophthalmology 1982;89:187-197.Crossref 4. Schwartz AL, Whitten ME, Bleiman B, et al: Argon laser trabecular surgery in uncontrolled phakic open-angle glaucoma . Ophthalmology 1981;88:203-212.Crossref 5. Wilensky JT, Jampol LM: Laser therapy for open-angle glaucoma . Ophthalmology 1981; 88:213-217.Crossref 6. Thomas JV, Simmons RJ, Belcher CD: Complications of argon laser trabeculoplasty . Glaucoma 1982;4:50-52. 7. Wickham MG, Worthen DM: Long-term follow-up of patients treated with the argon laser trabeculoplasty procedure . Ophthalmology 1979; 86:495-503.Crossref 8. Hoskins MD, Hetherington J, Minckler DS, et al: Complications of laser trabeculoplasty . Ophthalmology 1983;90:796-799.Crossref 9. Melamed S, Pei J, Puliafito C, et al: Q-switched neodymium-YAG laser trabeculopuncture in monkeys . Arch Ophthalmol 1985;103:129-133.Crossref 10. Greenidge KG, Rodrigues MM, Spaeth GL, et al: Acute intraocular pressure elevation after argon laser trabeculoplasty and iridectomy: A clinicopathologic study . Ophthalmic Surg 1984; 15:105-110. 11. Krupin T, Kolker AE, Kass MA, et al: Intraocular pressure the day of argon laser trabeculoplasty in primary open-angle glaucoma . Ophthalmology 1984;91:361-365.Crossref 12. Rodrigues MM, Spaeth GL, Donohoo P: Electron microscopy of argon laser therapy in phakic open-angle glaucoma . Ophthalmology 1982;89:198-210.Crossref 13. Koss ML, March WF, Nordquist RE, et al: Acute intraocular pressure elevation produced by argon laser trabeculoplasty in the cynomolgus monkey . Arch Ophthalmol 1984;102:1699-1703.Crossref 14. Van Buskirk EM, Pond V, Rosenquist RC, et al: Argon laser trabeculoplasty: Studies on mechanism of action . Ophthalmology 1984;91: 1005-1010.Crossref 15. Masuyama Y: Histopathological study of anterior chamber angle after laser trabeculoplasty . Nippon Ganka Gakkai Zasshi 1984; 88:1007-1020. 16. Freddo TF, Pei JH, Bassett-Chu S, et al: Morphological and physiological effects of experimental pigmentary dispersion in monkey eyes . Invest Ophthalmol Vis Sci 1985;24( (suppl) ):85. 17. Johnson DH, Richardson TM, Epstein DL: Trabecular meshwork phagocytosis: Long-term response . Invest Ophthalmol Vis Sci 1985;24 ( (suppl) ):136. 18. Rohen JW: Why is intraocular pressure elevated in chronic simple glaucoma? Anatomical considerations . Ophthalmology 1983;90:758-765.Crossref 19. Rohen JW, Witmer R: Electron microscopic studies on the trabecular meshwork in glaucoma simplex . Graefes Arch Clin Exp Ophthalmol 1972;83:251-266.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Oct 1, 1985

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