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Gentamicin, Tobramycin, Amikacin, and Netilmicin Levels in Tears Following Intravenous Administration

Gentamicin, Tobramycin, Amikacin, and Netilmicin Levels in Tears Following Intravenous... Abstract • Peak and trough tear and serum concentrations were determined in 27 human volunteers undergoing intravenous (IV) gentamicin sulfate, tobramycin sulfate, amikacin sulfate, and netilmicin sulfate therapy. Although effective serum concentrations were achieved, tear levels were subtherapeutic. The mean peak tear concentrations were 0.4 μg/mL, 0.5 μg/ mL, 1.7 μg/mL, and 0.3 μg/mL for gentamicin, tobramycin, amikacin, and netilmicin, respectively. These levels did not approach the minimum inhibitory concentrations for Pseudomonas and raise some concern regarding the risk-benefit ratio of IV antibiotics for bacterial keratitis. References 1. Jones DB: Decision-making in the management of microbial keratitis . Ophthalmology 1981; 88:814-820.Crossref 2. Jones DB: Early diagnosis and therapy of bacterial corneal ulcer . Int Ophthalmol Clin 1973; 13:1-29.Crossref 3. Baum JL, Barza M, Shushan D, et al: Concentration of gentamicin in experimental corneal ulcer . Arch Ophthalmol 1974;92:315-317.Crossref 4. Davis SD, Sarff LD, Hyndiuk RA: Antibiotic therapy of experimental Pseudomonas keratitis in guinea pigs . Arch Ophthalmol 1977;95:1638-1643.Crossref 5. Davis SD, Sarff LD, Hyndiuk RA: Comparison of therapeutic routes in experimental Pseudomonas keratitis . Am J Ophthalmol 1979;87:710-716. 6. Baum J, Barza M: Topical vs. subconjunctival treatment of bacterial corneal ulcers . Ophthalmology 1983;90:162-168.Crossref 7. Leibowitz HM, Ryan WJ, Kupferman A: Route of antibiotic administration in bacterial keratitis . Arch Ophthalmol 1981;99:1420-1423.Crossref 8. Woolfrey BF, Fox JM, Quail CO: A comparison of minimum inhibitory concentration values determined by three antimicrobic dilution methods for Pseudomonas aeruginosa . Am J Clin Pathol 1981;75:39-44. 9. Goodman LS, Gilman A: The Pharmacological Basis of Therapeutics , ed 6. New York, Macmillan Publishing Co, Inc, 1980, pp 1162-1178. 10. Sloane H, Peyman GA, Raichand M, et al: Netilmicin: A new aminoglycoside effective against bacterial endophthalmitis . Can J Ophthalmol 1981;16:22-26. 11. Eiferman RA, Stagner JI: Intraocular penetration of amikacin . Arch Ophthalmol 1982; 100:1817-1819.Crossref 12. Furgiuele FP, Smith JP, Baron JG: Tobramycin levels in human eyes . Am J Ophthalmol 1978;85:121-123. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Gentamicin, Tobramycin, Amikacin, and Netilmicin Levels in Tears Following Intravenous Administration

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1985.01050020068022
Publisher site
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Abstract

Abstract • Peak and trough tear and serum concentrations were determined in 27 human volunteers undergoing intravenous (IV) gentamicin sulfate, tobramycin sulfate, amikacin sulfate, and netilmicin sulfate therapy. Although effective serum concentrations were achieved, tear levels were subtherapeutic. The mean peak tear concentrations were 0.4 μg/mL, 0.5 μg/ mL, 1.7 μg/mL, and 0.3 μg/mL for gentamicin, tobramycin, amikacin, and netilmicin, respectively. These levels did not approach the minimum inhibitory concentrations for Pseudomonas and raise some concern regarding the risk-benefit ratio of IV antibiotics for bacterial keratitis. References 1. Jones DB: Decision-making in the management of microbial keratitis . Ophthalmology 1981; 88:814-820.Crossref 2. Jones DB: Early diagnosis and therapy of bacterial corneal ulcer . Int Ophthalmol Clin 1973; 13:1-29.Crossref 3. Baum JL, Barza M, Shushan D, et al: Concentration of gentamicin in experimental corneal ulcer . Arch Ophthalmol 1974;92:315-317.Crossref 4. Davis SD, Sarff LD, Hyndiuk RA: Antibiotic therapy of experimental Pseudomonas keratitis in guinea pigs . Arch Ophthalmol 1977;95:1638-1643.Crossref 5. Davis SD, Sarff LD, Hyndiuk RA: Comparison of therapeutic routes in experimental Pseudomonas keratitis . Am J Ophthalmol 1979;87:710-716. 6. Baum J, Barza M: Topical vs. subconjunctival treatment of bacterial corneal ulcers . Ophthalmology 1983;90:162-168.Crossref 7. Leibowitz HM, Ryan WJ, Kupferman A: Route of antibiotic administration in bacterial keratitis . Arch Ophthalmol 1981;99:1420-1423.Crossref 8. Woolfrey BF, Fox JM, Quail CO: A comparison of minimum inhibitory concentration values determined by three antimicrobic dilution methods for Pseudomonas aeruginosa . Am J Clin Pathol 1981;75:39-44. 9. Goodman LS, Gilman A: The Pharmacological Basis of Therapeutics , ed 6. New York, Macmillan Publishing Co, Inc, 1980, pp 1162-1178. 10. Sloane H, Peyman GA, Raichand M, et al: Netilmicin: A new aminoglycoside effective against bacterial endophthalmitis . Can J Ophthalmol 1981;16:22-26. 11. Eiferman RA, Stagner JI: Intraocular penetration of amikacin . Arch Ophthalmol 1982; 100:1817-1819.Crossref 12. Furgiuele FP, Smith JP, Baron JG: Tobramycin levels in human eyes . Am J Ophthalmol 1978;85:121-123.

Journal

Archives of Ophthalmology – American Medical Association

Published: Feb 1, 1985

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