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W. Cox, A. Kupferman, H. Leibowitz (1972)
Topically applied steroids in corneal disease. II. The role of drug vehicle in stromal absorption of dexamethasone.Archives of Ophthalmology, 88
Flinn PE Juenge EC (1981)
Quantitative TLC determination of epimeric ratios of 16-methyl 18-ketone oxidation products of dexamethasone and related drugsJ Pharmacol Sci, 70
H. Leibowitz, A. Kupferman, R. Stewart, R. Kimbrough (1978)
Evaluation of dexamethasone acetate as a topical ophthalmic formulation.American journal of ophthalmology, 86 3
W. Cox, A. Kupferman, H. Leibowitz (1972)
Topically applied steroids in corneal disease. I. The role of inflammation in stromal absorption of dexamethasone.Archives of Ophthalmology, 88
Abstract • An in vitro method for evaluating efficacy of ophthalmic steroid preparations was developed using bovine eyes. The method was tested using three derivatives of dexamethasone (alcohol, acetate, and sodium phosphate) and the results obtained were similar to those obtained in studies using live rabbits, although differences were noted. Bioavailability of the acetate was greatest; that of the sodium phosphate was the lowest. On the basis of this study, bovine eyes could be used as an alternative method for assessing ophthalmic steroid efficacy. References 1. Kupferman A, Pratt MV, Suckewer K, et al: Topically applied steroids in corneal disease: III. The role of drug derivative in stromal absorption of dexamethasone . Arch Ophthalmol 1974;91:373-376.Crossref 2. Leibowitz HM, Kupferman A, Stewart RH, et al: Evaluation of dexamethasone acetate as a topical ophthalmic formulation . Am J Ophthalmol 1978;86:418-423. 3. Juenge EC, Flinn PE: Quantitative TLC determination of epimeric ratios of 16-methyl 18-ketone oxidation products of dexamethasone and related drugs . J Pharmacol Sci 1981;70:415-418.Crossref 4. Cox WV, Kupferman A, Leibowitz HM: Topically applied steroids in corneal disease: I. The role of inflammation in stromal absorption of dexamethasone . Arch Ophthalmol 1972;88:308-313.Crossref
Archives of Ophthalmology – American Medical Association
Published: Dec 1, 1984
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