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Cavernous Hemangioma of the Retina: Immunohistochemical and Ultrastructural Observations

Cavernous Hemangioma of the Retina: Immunohistochemical and Ultrastructural Observations Abstract • A 6-month old girl had unilateral leukokoria. Because retinoblastoma could not be excluded, the blind left eye was enucleated. Histopathologically, a total retinal detachment associated with a widespread cavernous hemangioma of the retina and a preretinal membrane were found. The specimen was further examined by immunohistochemistry and electron microscopy to determine the origin of the preretinal membrane and to study the anatomy of the telangiectatic retinal vessels. The preretinal membrane was mostly composed of spindle-shaped cells that demonstrated immunohistochemically the presence of glial fibrillary-acidic protein and showed, ultrastructurally, numerous glial filaments in their cytoplasm. These findings support the view that this membrane was of glial origin. By electron microscopy, the telangiectatic retinal vessels displayed the anatomic features normally encountered in retinal vessels, which accounts for the absence of exudates observed clinically and angiographically in cases of cavernous hemangioma of the retina. References 1. Niccol W, Moore RF: A case of angiomatosis retinae . Br J Ophthalmol 1934;18:454-457.Crossref 2. Appelmans M, Decock G, van Opstal R: Traitement de l'angiome rétinien par diathermocoagulation . Bull Soc Belge Ophtalmol 1949; 92:326-341. 3. Davies WS, Thumim M: Cavernous hemangioma of the optic disc and retina . Trans Am Acad Ophthalmol Otolaryngol 1956;60:217-218. 4. Kogan L, Boniuk M: Causes for enucleation in childhood with special reference to pseudogliomas and unsuspected retinoblastomas . Int Ophthalmol Clin 1962;2:507-524.Crossref 5. Gass JDM: Cavernous hemangioma of the retina . Am J Ophthalmol 1971;71:799-814. 6. Sternberger LA, Hardy PH, Cuculis JJ, et al: The unlabeled antibody enzyme method of immunohistochemistry: Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes . J Histochem Cytochem 1970;18:315-555.Crossref 7. Reese AB: Telangiectasis of the retina and Coats' disease . Am J Ophthalmol 1956;42:1-8. 8. Wessing A: Fluorescein Angiography of the Retina: Textbook and Atlas , von Noorden GK (trans). St Louis, CV Mosby Co, 1969, pp 132-133. 9. Egerer I, Tasman W, Tomer TL: Coats' disease . Arch Ophthalmol 1974;92:109-112.Crossref 10. Tripathi R, Ashton N: Electron microscopical study of Coats' disease . Br J Ophthalmol 1971;55:289-301.Crossref 11. Foos RY: Nonvascular proliferative extra-retinal retinopathies . Am J Ophthalmol 1978; 86:723-725. 12. Laqua H, Machemer R: Glial cell proliferation in retinal detachment (massive periretinal proliferation) . Am J Ophthalmol 1975;80:602-618. 13. Lewis RA, Cohen MH, Wise GN: Cavernous hemangioma of the retina and optic disc . Br J Ophthalmol 1975;59:422-434.Crossref 14. Krause U: A case of cavernous haemangioma of the retina . Acta Ophthalmol 1971;49:221-231.Crossref 15. Scheyhing H: Ein seltener Fall von angiomatösen Veränderungen der Netzhaut . Klin Monatsbl Augenheilkd 1937;99:362-367. 16. Witmer R, Verrey F, Speiser P: Retinal angiomatosis. Atypical cases of retinal angiomatosis and telangiectases . Bibl Ophthalmol 1968; 76:113-123. 17. Klein M, Goldberg MF, Cotlier E: Cavernous hemangioma of the retina . Ann Ophthalmol 1975;7:1213-1221. 18. Winning von CHOM: Hemangiomas of the fundus . Doc Ophthalmol 1976;40:361-381.Crossref 19. Turut P, Francois P: Hémangiome caverneux de la retine . J Fr Ophthalmol 1979;2:393-404. 20. Gislason I, Stenkula S, Alm A, et al: Cavernous hemangioma of the retina . Acta Ophthalmol 1976;57:709-717.Crossref 21. Augsburger JJ, Shields JA, Goldberg RE: Classification and management of hereditary retinal angiomas . Int Ophthalmol 1981;4:93-106.Crossref 22. Gautier-Smith PC, Sanders MD, Sanderson KV: Ocular and nervous system involvement in angioma serpinginosum . Br J Ophthalmol 1971;55:433-443.Crossref 23. Colvard DM, Robertson DM, Trautmann JC: Cavernous hemangioma of the retina . Arch Ophthalmol 1978;96:2042-2044.Crossref 24. Goldberg RE, Pheasant TR, Shields JA: Cavernous hemangioma of the retina . Arch Ophthalmol 1979;97:2321-2324.Crossref 25. Voigt K, Yasargil MG: Cerebral cavernous haemangiomas or cavernomas: Incidence, pathology, localization, diagnosis, clinical features and treatment: Review of the literature and report of an unusual case . Neurochirurgia 1976;19:59-68. 26. Roberson GH, Kase CS, Wolpow ER: Telangiectases and cavernous angiomas of the brainstem: 'Cryptic' vascular malformations . Neuroradiology 1974;8:83-89.Crossref 27. McCormick WF, Hardman JM, Boulter TR: Vascular malformations ('angiomas') of the brain, with special reference to those occurring in the posterior fossa . J Neurosurg 1968;28:241-251.Crossref 28. Davis DG, Smith JL: Retinal involvement in hereditary hemorrhagic telangiectasia . Arch Ophthalmol 1971;85:618-623.Crossref 29. Welch RB: Von Hippel-Lindau disease: The recognition and treatment of early angiomatosis retinae and the use of cryosurgery as an adjunct to therapy . Trans Am Ophthalmol Soc 1970; 68:367-424. 30. Archer DB, Deutman A, Ernest JT, et al: Arteriovenous communications of the retina . Am J Ophthalmol 1973;75:224-241. 31. Jurco S, Nadji M, Harvey DG, et al: Hemangioblastomas: Histogenesis of the stromal cell studied by immunocytochemistry . Hum Pathol 1982;13:13-18.Crossref 32. Cameron ME, Greer CH: Congenital arterio-venous aneurysm of the retina: A postmortem report . Br J Ophthalmol 1968;52:768-772.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Cavernous Hemangioma of the Retina: Immunohistochemical and Ultrastructural Observations

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References (34)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030331031
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Abstract

Abstract • A 6-month old girl had unilateral leukokoria. Because retinoblastoma could not be excluded, the blind left eye was enucleated. Histopathologically, a total retinal detachment associated with a widespread cavernous hemangioma of the retina and a preretinal membrane were found. The specimen was further examined by immunohistochemistry and electron microscopy to determine the origin of the preretinal membrane and to study the anatomy of the telangiectatic retinal vessels. The preretinal membrane was mostly composed of spindle-shaped cells that demonstrated immunohistochemically the presence of glial fibrillary-acidic protein and showed, ultrastructurally, numerous glial filaments in their cytoplasm. These findings support the view that this membrane was of glial origin. By electron microscopy, the telangiectatic retinal vessels displayed the anatomic features normally encountered in retinal vessels, which accounts for the absence of exudates observed clinically and angiographically in cases of cavernous hemangioma of the retina. References 1. Niccol W, Moore RF: A case of angiomatosis retinae . Br J Ophthalmol 1934;18:454-457.Crossref 2. Appelmans M, Decock G, van Opstal R: Traitement de l'angiome rétinien par diathermocoagulation . Bull Soc Belge Ophtalmol 1949; 92:326-341. 3. Davies WS, Thumim M: Cavernous hemangioma of the optic disc and retina . Trans Am Acad Ophthalmol Otolaryngol 1956;60:217-218. 4. Kogan L, Boniuk M: Causes for enucleation in childhood with special reference to pseudogliomas and unsuspected retinoblastomas . Int Ophthalmol Clin 1962;2:507-524.Crossref 5. Gass JDM: Cavernous hemangioma of the retina . Am J Ophthalmol 1971;71:799-814. 6. Sternberger LA, Hardy PH, Cuculis JJ, et al: The unlabeled antibody enzyme method of immunohistochemistry: Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes . J Histochem Cytochem 1970;18:315-555.Crossref 7. Reese AB: Telangiectasis of the retina and Coats' disease . Am J Ophthalmol 1956;42:1-8. 8. Wessing A: Fluorescein Angiography of the Retina: Textbook and Atlas , von Noorden GK (trans). St Louis, CV Mosby Co, 1969, pp 132-133. 9. Egerer I, Tasman W, Tomer TL: Coats' disease . Arch Ophthalmol 1974;92:109-112.Crossref 10. Tripathi R, Ashton N: Electron microscopical study of Coats' disease . Br J Ophthalmol 1971;55:289-301.Crossref 11. Foos RY: Nonvascular proliferative extra-retinal retinopathies . Am J Ophthalmol 1978; 86:723-725. 12. Laqua H, Machemer R: Glial cell proliferation in retinal detachment (massive periretinal proliferation) . Am J Ophthalmol 1975;80:602-618. 13. Lewis RA, Cohen MH, Wise GN: Cavernous hemangioma of the retina and optic disc . Br J Ophthalmol 1975;59:422-434.Crossref 14. Krause U: A case of cavernous haemangioma of the retina . Acta Ophthalmol 1971;49:221-231.Crossref 15. Scheyhing H: Ein seltener Fall von angiomatösen Veränderungen der Netzhaut . Klin Monatsbl Augenheilkd 1937;99:362-367. 16. Witmer R, Verrey F, Speiser P: Retinal angiomatosis. Atypical cases of retinal angiomatosis and telangiectases . Bibl Ophthalmol 1968; 76:113-123. 17. Klein M, Goldberg MF, Cotlier E: Cavernous hemangioma of the retina . Ann Ophthalmol 1975;7:1213-1221. 18. Winning von CHOM: Hemangiomas of the fundus . Doc Ophthalmol 1976;40:361-381.Crossref 19. Turut P, Francois P: Hémangiome caverneux de la retine . J Fr Ophthalmol 1979;2:393-404. 20. Gislason I, Stenkula S, Alm A, et al: Cavernous hemangioma of the retina . Acta Ophthalmol 1976;57:709-717.Crossref 21. Augsburger JJ, Shields JA, Goldberg RE: Classification and management of hereditary retinal angiomas . Int Ophthalmol 1981;4:93-106.Crossref 22. Gautier-Smith PC, Sanders MD, Sanderson KV: Ocular and nervous system involvement in angioma serpinginosum . Br J Ophthalmol 1971;55:433-443.Crossref 23. Colvard DM, Robertson DM, Trautmann JC: Cavernous hemangioma of the retina . Arch Ophthalmol 1978;96:2042-2044.Crossref 24. Goldberg RE, Pheasant TR, Shields JA: Cavernous hemangioma of the retina . Arch Ophthalmol 1979;97:2321-2324.Crossref 25. Voigt K, Yasargil MG: Cerebral cavernous haemangiomas or cavernomas: Incidence, pathology, localization, diagnosis, clinical features and treatment: Review of the literature and report of an unusual case . Neurochirurgia 1976;19:59-68. 26. Roberson GH, Kase CS, Wolpow ER: Telangiectases and cavernous angiomas of the brainstem: 'Cryptic' vascular malformations . Neuroradiology 1974;8:83-89.Crossref 27. McCormick WF, Hardman JM, Boulter TR: Vascular malformations ('angiomas') of the brain, with special reference to those occurring in the posterior fossa . J Neurosurg 1968;28:241-251.Crossref 28. Davis DG, Smith JL: Retinal involvement in hereditary hemorrhagic telangiectasia . Arch Ophthalmol 1971;85:618-623.Crossref 29. Welch RB: Von Hippel-Lindau disease: The recognition and treatment of early angiomatosis retinae and the use of cryosurgery as an adjunct to therapy . Trans Am Ophthalmol Soc 1970; 68:367-424. 30. Archer DB, Deutman A, Ernest JT, et al: Arteriovenous communications of the retina . Am J Ophthalmol 1973;75:224-241. 31. Jurco S, Nadji M, Harvey DG, et al: Hemangioblastomas: Histogenesis of the stromal cell studied by immunocytochemistry . Hum Pathol 1982;13:13-18.Crossref 32. Cameron ME, Greer CH: Congenital arterio-venous aneurysm of the retina: A postmortem report . Br J Ophthalmol 1968;52:768-772.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Mar 1, 1984

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