Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Systemic Steroids or Aminocaproic Acid in the Management of Traumatic Hyphema?—Yes!-Reply

Systemic Steroids or Aminocaproic Acid in the Management of Traumatic Hyphema?—Yes!-Reply Abstract In Reply. —One of the major advances in clinical medicine in recent years has been the application of epidemiologic principles to the solution of pressing clinical problems. Major clinical trials have used these principles to avoid potential or actual biases in determining the efficacy of therapy for such problems as diabetic retinopathy,' macular degeneration,2 and sickle cell retinopathy.3 Prospective, randomized, controlled protocols with masked observations are important in such undertakings, and may give different results from more poorly constructed studies (compare the results of references 4 and 5 and references 6 and 7).Dr Romano believes that previous investigations have proved the value of systemic corticosteroids in reducing the rate of secondary hemorrhage following traumatic hyphema.6 Although these studies are of interest, the methodologies employed were deficient enough that we cannot agree. For example, the use of historic data, as well as data from patients of a References 1. The Diabetic Retinopathy Study Research Group: Preliminary report on effects of photocoagulation therapy . Am J Ophthalmol 1976;81:383-396. 2. Macular Photocoagulation Study Group: Argon laser photocoagulation for senile macular degeneration: Results of a randomized clinical trial . Arch Ophthalmol 1982;100:912-918.Crossref 3. Jampol LM, Condon P, Farber M, et al: A randomized clinical trial of feeder vessel photocoagulation of proliferative sickle cell retinopathy . Ophthalmology 1983;90:540-545.Crossref 4. Roper DL, Nesbit RM: Effect of hyaluronidase on the incidence of cystoid macular edema . Ann Ophthalmol 1978;10:1673-1678. 5. Kraff MC, Sanders DR, Jampol LM, et al: Effect of retrobulbar hyaluronidase on pseudophakic cystoid macular edema . Am Intraocular Implant Soc J 1983;9:184-185.Crossref 6. Rynne MV, Romano P: Systemic corticosteroid in the treatment of traumatic hyphema . J Pediatr Ophthalmol Strabismus 1980;17:141-143. 7. Fujikawa LS, Meisler DM, Nozik RA: Hyperosmolar hyperglycemic nonketotic coma: A complication of short-term systemic corticosteriod use . Ophthalmology 1983;90:1239-1242.Crossref 8. Spoor TC, Hammer ME, Belloso H: Traumatic hyphema: Failure of steroids to alter its course: A double-blind prospective study . Arch Ophthalmol 1980;98:116-119.Crossref 9. Spoor TC, Hammer ME: Traumatic hyphema . Arch Ophthalmol 1981;99:2053-2054.Crossref 10. Goldberg MF: Antifibrinolytic agents in the management of traumatic hyphema . Arch Ophthalmol 1983;101:1029-1030.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Systemic Steroids or Aminocaproic Acid in the Management of Traumatic Hyphema?—Yes!-Reply

Systemic Steroids or Aminocaproic Acid in the Management of Traumatic Hyphema?—Yes!-Reply

Abstract

Abstract In Reply. —One of the major advances in clinical medicine in recent years has been the application of epidemiologic principles to the solution of pressing clinical problems. Major clinical trials have used these principles to avoid potential or actual biases in determining the efficacy of therapy for such problems as diabetic retinopathy,' macular degeneration,2 and sickle cell retinopathy.3 Prospective, randomized, controlled protocols with masked observations are...
Loading next page...
 
/lp/american-medical-association/systemic-steroids-or-aminocaproic-acid-in-the-management-of-traumatic-AoL4uCEkvd

References (12)

Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030143006
Publisher site
See Article on Publisher Site

Abstract

Abstract In Reply. —One of the major advances in clinical medicine in recent years has been the application of epidemiologic principles to the solution of pressing clinical problems. Major clinical trials have used these principles to avoid potential or actual biases in determining the efficacy of therapy for such problems as diabetic retinopathy,' macular degeneration,2 and sickle cell retinopathy.3 Prospective, randomized, controlled protocols with masked observations are important in such undertakings, and may give different results from more poorly constructed studies (compare the results of references 4 and 5 and references 6 and 7).Dr Romano believes that previous investigations have proved the value of systemic corticosteroids in reducing the rate of secondary hemorrhage following traumatic hyphema.6 Although these studies are of interest, the methodologies employed were deficient enough that we cannot agree. For example, the use of historic data, as well as data from patients of a References 1. The Diabetic Retinopathy Study Research Group: Preliminary report on effects of photocoagulation therapy . Am J Ophthalmol 1976;81:383-396. 2. Macular Photocoagulation Study Group: Argon laser photocoagulation for senile macular degeneration: Results of a randomized clinical trial . Arch Ophthalmol 1982;100:912-918.Crossref 3. Jampol LM, Condon P, Farber M, et al: A randomized clinical trial of feeder vessel photocoagulation of proliferative sickle cell retinopathy . Ophthalmology 1983;90:540-545.Crossref 4. Roper DL, Nesbit RM: Effect of hyaluronidase on the incidence of cystoid macular edema . Ann Ophthalmol 1978;10:1673-1678. 5. Kraff MC, Sanders DR, Jampol LM, et al: Effect of retrobulbar hyaluronidase on pseudophakic cystoid macular edema . Am Intraocular Implant Soc J 1983;9:184-185.Crossref 6. Rynne MV, Romano P: Systemic corticosteroid in the treatment of traumatic hyphema . J Pediatr Ophthalmol Strabismus 1980;17:141-143. 7. Fujikawa LS, Meisler DM, Nozik RA: Hyperosmolar hyperglycemic nonketotic coma: A complication of short-term systemic corticosteriod use . Ophthalmology 1983;90:1239-1242.Crossref 8. Spoor TC, Hammer ME, Belloso H: Traumatic hyphema: Failure of steroids to alter its course: A double-blind prospective study . Arch Ophthalmol 1980;98:116-119.Crossref 9. Spoor TC, Hammer ME: Traumatic hyphema . Arch Ophthalmol 1981;99:2053-2054.Crossref 10. Goldberg MF: Antifibrinolytic agents in the management of traumatic hyphema . Arch Ophthalmol 1983;101:1029-1030.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1984

There are no references for this article.