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D. Gregory, M. Sears, L. Bausher, H. Mishima, A. Mead (1981)
Intraocular pressure and aqueous flow are decreased by cholera toxin.Investigative ophthalmology & visual science, 20 3
K. Eakins (1977)
Prostaglandin and non-prostaglandin mediated breeakdown of the blood-aqueous barrier.Experimental eye research, 25 Suppl
Hedbys, Dohlman, A. Neufeld, Marvin Sears (1975)
Adenosine 3',5'-monophosphate analogue increases the outflow facility of the primate eye.Investigative ophthalmology, 14 9
A. Neufeld, L. Jampol, M. Sears (1972)
Cyclic-AMP in the aqueous humor: the effects of adrenergic agents.Experimental eye research, 14 3
Sharma PV (1956)
Dravya Guna Vigyan: Parts II and III
K. Seamon, W. Padgett, J. Daly (1981)
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.Proceedings of the National Academy of Sciences of the United States of America, 78 6
Padgett W Seamon KB (1981)
Unique diterpene activator of adenylate cyclase in membranes and in intact cellsProc Natl Acad Sci USA, 78
E. Lindner, Dohadwalla An, Bhattacharya Bk (1978)
Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin.Arzneimittel-Forschung, 28 2
H. Metzger, E. Lindner (1981)
The positive inotropic-acting forskolin, a potent adenylate cyclase activator.Arzneimittel-Forschung, 31 8
Chunekar KC (1960)
Bhav Prakash Nighantu
Butcher RW Robinson GA (1971)
Cyclic AMP
A. Siegl, J. Daly, J. Smith (1982)
Inhibition of aggregation and stimulation of cyclic AMP generation in intact human platelets by the diterpene forskolin.Molecular pharmacology, 21 3
Abstract • To our knowledge, this is the first report of a topically applied, specific adenylate cyclase activator that reduces intraocular pressure. Forskolin, a novel adenylate cyclase activator, is reported to increase cyclic adenosine monophosphate (AMP) in intact cells. Cyclic AMP levels are increased with various antiglaucoma agents. Intraocular pressure in rabbits was significantly reduced with two concentrations of forskolin, 0.1% and 0.05%. Ocular hypertension was noted with 0.5% and 0.2%. No change in IOP was noted with 0.01% forskolin. The IOP lowering with 0.1% and 0.05% forskolin lasted approximately six hours. Mild, transient conjunctival chemosis was noted in the doses that decreased IOP. The contralateral control eye showed decreases in IOP, but the differences between control and tested eyes were significant by the Student's paired t test. References 1. Chunekar KC: Bhav Prakash Nighantu , Hindi translation. Chaukhamba Vidya Bhavan, Banaras, India, 1960, p 86. 2. Sharma PV: Dravya Guna Vigyan: Parts II and III . Chaukhamba Vidaya Bhavan, Banaras, India, 1956, p 273. 3. Linder E, Dohadwalla A, Bhattacharya B: Positive inotropic and blood pressure lowering activity in a diterpene derivative isolated from coleus forskolin: Forskolin . Arzneimittelforsch 1978;28:284-289. 4. Robinson GA, Butcher RW, Sutherland EW: Cyclic AMP . New York, Academic Press Inc, 1971. 5. Metzger H, Linder E: The positive inotropicacting forskolin: A potent adenylatecyclase activator . Arzneimittelforsch 1981;31:1248-1250. 6. Siegl A, Daly J, Smith J: Inhibition of aggregation and stimulation of cyclic AMP generation in intact human platelets by the diterpene forskolin . Mol Pharmacol 1982;21:680-687. 7. Neufeld A, Jampol L, Sears M: Cyclic-AMP in the aqueous humor: The effects of adrenergic agents . Exp Eye Res 1972;14:242-250.Crossref 8. Neufeld A, Sears M: Adenosine 3′,5′monophosphate analogue increases the outflow facility of the primate eye . Invest Ophthalmol Vis Sci 1975;14:688-689. 9. Seamon KB, Padgett W, Daly J: Forskolin: Unique diterpene activator of adenylate cyclase in membranes and in intact cells . Proc Natl Acad Sci USA 1981;78:3363-3367.Crossref 10. Gregory D, Sears M, Bausher L, et al: Intraocular pressure and aqueous flow are decreased by cholera toxin . Invest Ophthalmol Vis Sci 1981;20:371-381. 11. Eakins KE: Prostaglandin and non-prostaglandin mediated breakdown of the blood-aqueous barrier . Exp Eye Res 1977;25( (suppl) ):483-498.Crossref
Archives of Ophthalmology – American Medical Association
Published: Jan 1, 1984
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