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Hematoporphyrin Phototherapy for Experimental Intraocular Malignant Melanoma

Hematoporphyrin Phototherapy for Experimental Intraocular Malignant Melanoma Abstract • Administration of a hematoporphyrin derivative (HpD) followed by photoradiation with red light completely or partially destroyed Greene hamster melanoma developed in the anterior chamber of rabbit eyes. Tumor-bearing eyes were divided into two groups. Twenty-two eyes received an HpD injection followed by exposure to red light from a slide projector with a 500-W quartz halogen lamp and a red filter (intensity to the tumor was about 4.0 mW/sq cm). In the control group (six eyes), eyes were exposed either to red light only or to HpD injection only. Local complications after therapy included edema and congestion of the conjunctiva, clouding of the cornea, and hemorrhage on the iris surface. The HpD itself has no cytotoxic effect, is preferentially retained in tumor cells, and causes a destructive photodynamic effect as a result of the production of cytotoxic singlet oxygen in the tumor. Accordingly, it may be a safe and potentially therapeutic procedure in the treatment of uveal melanoma. n.amon References 1. Sery TW: Photodynamic killing of retinoblastoma cells with hematoporphyrin and light . Cancer Res 1979;39:96-100. 2. Benedict WF, Lingua RW, Doiron DR, et al: Tumor regression of human retinoblastoma in the nude mouse following photoradiation therapy: A preliminary report . Med Pediatr Oncol 1980;8:397-401.Crossref 3. Murphree AL, Benedict WF, Lingua RW, et al: Hematoporphyrin phototherapy in the treatment of retinoblastoma . Invest Ophthalmol Vis Sci 1981;20 ( (suppl) ):162. 4. Gomer CJ, Rucker N, Mark C, et al: Tissue distribution of 3H-hematoporphyrin derivative in athymic 'nude' mice heterotransplanted with human retinoblastoma . Invest Ophthalmol Vis Sci 1982;22:118-120. 5. Cunningham RD, Henderson JW: Experimental evaluation of hematoporphyrin in the detection and management of intraocular tumors . Am J Ophthalmol 1966;61:36-44. 6. Krohn DL, Jacobs R, Morris DA: Diagnosis of model choroidal malignant melanoma by hematoporphyrin derivative fluorescence in rabbits . Invest Ophthalmol Vis Sci 1974;13:244-255. 7. Dougherty T, Boyle D, Weishaupt K, et al: Phototherapy of human tumors , in Castellani R (ed): Research in Photobiology . New York, Plenum Press, 1976, pp 435-446. 8. Lipson RL, Baldes EJ, Olsen AM: The use of a derivative of hematoporphyrin in tumor detection . JNCI 1961;26:1-11. 9. Sanderson DR, Fontana RS, Lipson RL, et al: Hematoporphyrin as a diagnostic tool: A preliminary report of new techniques . Cancer 1972;30:1368-1372.Crossref 10. Jori G, Pizzi G, Reddi E, et al: Time dependence of hematoporphyrin distribution in selected tissues of normal rats and in ascites hepatomas . Tumori 1979;65:425-434. 11. Henderson RW, Christie GS, Clezy PS, et al: Hematoporphyrin diacetate: A probe to distinguish malignant from normal tissue by selective fluorescence . Br J Exp Pathol 1980;61:345-350. 12. Politzer IR, Griffin GW, Laseter JL: Singlet oxygen and biological systems . Chem Biol Interact 1971;3:73-93.Crossref 13. Weishaupt KR, Gomer CJ, Dougherty TJ: Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor . Cancer Res 1976;36:2326-2329. 14. Liu HS, Refojo MF, Albert DM: Experimental combined systemic and local chemotherapy for intraocular malignancy . Arch Ophthalmol 1980;98:905-908.Crossref 15. Liu LHS, Refojo MF, Ni C, et al: Sustained release of carmustine (BCNU) for treatment of experimental intraocular malignancy. Br J Ophthalmol, in press. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Hematoporphyrin Phototherapy for Experimental Intraocular Malignant Melanoma

Archives of Ophthalmology , Volume 101 (6) – Jun 1, 1983

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1983.01040010901009
Publisher site
See Article on Publisher Site

Abstract

Abstract • Administration of a hematoporphyrin derivative (HpD) followed by photoradiation with red light completely or partially destroyed Greene hamster melanoma developed in the anterior chamber of rabbit eyes. Tumor-bearing eyes were divided into two groups. Twenty-two eyes received an HpD injection followed by exposure to red light from a slide projector with a 500-W quartz halogen lamp and a red filter (intensity to the tumor was about 4.0 mW/sq cm). In the control group (six eyes), eyes were exposed either to red light only or to HpD injection only. Local complications after therapy included edema and congestion of the conjunctiva, clouding of the cornea, and hemorrhage on the iris surface. The HpD itself has no cytotoxic effect, is preferentially retained in tumor cells, and causes a destructive photodynamic effect as a result of the production of cytotoxic singlet oxygen in the tumor. Accordingly, it may be a safe and potentially therapeutic procedure in the treatment of uveal melanoma. n.amon References 1. Sery TW: Photodynamic killing of retinoblastoma cells with hematoporphyrin and light . Cancer Res 1979;39:96-100. 2. Benedict WF, Lingua RW, Doiron DR, et al: Tumor regression of human retinoblastoma in the nude mouse following photoradiation therapy: A preliminary report . Med Pediatr Oncol 1980;8:397-401.Crossref 3. Murphree AL, Benedict WF, Lingua RW, et al: Hematoporphyrin phototherapy in the treatment of retinoblastoma . Invest Ophthalmol Vis Sci 1981;20 ( (suppl) ):162. 4. Gomer CJ, Rucker N, Mark C, et al: Tissue distribution of 3H-hematoporphyrin derivative in athymic 'nude' mice heterotransplanted with human retinoblastoma . Invest Ophthalmol Vis Sci 1982;22:118-120. 5. Cunningham RD, Henderson JW: Experimental evaluation of hematoporphyrin in the detection and management of intraocular tumors . Am J Ophthalmol 1966;61:36-44. 6. Krohn DL, Jacobs R, Morris DA: Diagnosis of model choroidal malignant melanoma by hematoporphyrin derivative fluorescence in rabbits . Invest Ophthalmol Vis Sci 1974;13:244-255. 7. Dougherty T, Boyle D, Weishaupt K, et al: Phototherapy of human tumors , in Castellani R (ed): Research in Photobiology . New York, Plenum Press, 1976, pp 435-446. 8. Lipson RL, Baldes EJ, Olsen AM: The use of a derivative of hematoporphyrin in tumor detection . JNCI 1961;26:1-11. 9. Sanderson DR, Fontana RS, Lipson RL, et al: Hematoporphyrin as a diagnostic tool: A preliminary report of new techniques . Cancer 1972;30:1368-1372.Crossref 10. Jori G, Pizzi G, Reddi E, et al: Time dependence of hematoporphyrin distribution in selected tissues of normal rats and in ascites hepatomas . Tumori 1979;65:425-434. 11. Henderson RW, Christie GS, Clezy PS, et al: Hematoporphyrin diacetate: A probe to distinguish malignant from normal tissue by selective fluorescence . Br J Exp Pathol 1980;61:345-350. 12. Politzer IR, Griffin GW, Laseter JL: Singlet oxygen and biological systems . Chem Biol Interact 1971;3:73-93.Crossref 13. Weishaupt KR, Gomer CJ, Dougherty TJ: Identification of singlet oxygen as the cytotoxic agent in photo-inactivation of a murine tumor . Cancer Res 1976;36:2326-2329. 14. Liu HS, Refojo MF, Albert DM: Experimental combined systemic and local chemotherapy for intraocular malignancy . Arch Ophthalmol 1980;98:905-908.Crossref 15. Liu LHS, Refojo MF, Ni C, et al: Sustained release of carmustine (BCNU) for treatment of experimental intraocular malignancy. Br J Ophthalmol, in press.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jun 1, 1983

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