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Fluorescein Appearance Time Curves: Continuous Recordings of Iris and Anterior Chamber Dye Flow Contours

Fluorescein Appearance Time Curves: Continuous Recordings of Iris and Anterior Chamber Dye Flow... Abstract • Fluorescein appearance time (FAT) curves were recorded at 5-s intervals from the feline iris and anterior chamber using a modified video-frame store unit. Anterior chamber washout slopes were also recorded following intracameral injection. The iris FAT interval following intravenous injection was maximally 5 s. Passage of the dye bolus then appeared during the next 10 s, followed by a rapid (100-s) rise to maximum levels. In contrast to the iris, anterior chamber FAT curves recorded from the pupillary space showed an approximate two-minute delay after injection (mean = 1.92 ± 0.360 minutes), followed by a gradual (20-minute) rise to maximum recordable levels. The mean anterior chamber washout rate following intracameral injection of 10-6 g/mL of dye levels was 2.323% ± 0.810%/min. There are potential applications of the method and a need for shorter recording intervals. References 1. O'Rourke J, Mendeloff T, D'Amato DP: Continuous in vivo recordings of intraocular capillary and aqueous humor flows . Ophthalmol Res 1978;10:212-224.Crossref 2. O'Rourke J, Lindsay M, Reddy S: Use of needle crimping to seal limbal punctures: Technical note . Ophthalmol Res 1980;12:57-63.Crossref 3. Kotow MH: Anterior Segment Fluorescein Angiography . Baltimore, Williams & Wilkins Co, 1978, pp 46-55. 4. Van Nerom PR, Rosenthal AR, Jacobson DR, et al: Iris angiography and aqueous photofluorometry in normal subjects . Arch Ophthalmol 1981;99:489-493.Crossref 5. Kraff MC, Sanders DR, Peyman GA, et al: Slit-lamp fluorophotometry in intraocular lens patients . Ophthalmology 1980;87:877-880.Crossref 6. Jones RF, Maurice DM: New methods of measuring the rate of aqueous flow in man with fluorescein . Exp Eye Res 1966;5:208-220.Crossref 7. Coakes RL, Brubaker RF: Method of measuring aqueous humor flow and corneal endothelial permeability using a fluorophotometry normogram . Invest Ophthalmol Vis Sci 1979;18:288-302. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Fluorescein Appearance Time Curves: Continuous Recordings of Iris and Anterior Chamber Dye Flow Contours

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030040805020
Publisher site
See Article on Publisher Site

Abstract

Abstract • Fluorescein appearance time (FAT) curves were recorded at 5-s intervals from the feline iris and anterior chamber using a modified video-frame store unit. Anterior chamber washout slopes were also recorded following intracameral injection. The iris FAT interval following intravenous injection was maximally 5 s. Passage of the dye bolus then appeared during the next 10 s, followed by a rapid (100-s) rise to maximum levels. In contrast to the iris, anterior chamber FAT curves recorded from the pupillary space showed an approximate two-minute delay after injection (mean = 1.92 ± 0.360 minutes), followed by a gradual (20-minute) rise to maximum recordable levels. The mean anterior chamber washout rate following intracameral injection of 10-6 g/mL of dye levels was 2.323% ± 0.810%/min. There are potential applications of the method and a need for shorter recording intervals. References 1. O'Rourke J, Mendeloff T, D'Amato DP: Continuous in vivo recordings of intraocular capillary and aqueous humor flows . Ophthalmol Res 1978;10:212-224.Crossref 2. O'Rourke J, Lindsay M, Reddy S: Use of needle crimping to seal limbal punctures: Technical note . Ophthalmol Res 1980;12:57-63.Crossref 3. Kotow MH: Anterior Segment Fluorescein Angiography . Baltimore, Williams & Wilkins Co, 1978, pp 46-55. 4. Van Nerom PR, Rosenthal AR, Jacobson DR, et al: Iris angiography and aqueous photofluorometry in normal subjects . Arch Ophthalmol 1981;99:489-493.Crossref 5. Kraff MC, Sanders DR, Peyman GA, et al: Slit-lamp fluorophotometry in intraocular lens patients . Ophthalmology 1980;87:877-880.Crossref 6. Jones RF, Maurice DM: New methods of measuring the rate of aqueous flow in man with fluorescein . Exp Eye Res 1966;5:208-220.Crossref 7. Coakes RL, Brubaker RF: Method of measuring aqueous humor flow and corneal endothelial permeability using a fluorophotometry normogram . Invest Ophthalmol Vis Sci 1979;18:288-302.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1982

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