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Kühnel W (1968)
Vergleichende histologische, histochemiche und elektronmikroskopische Untersuchungen an Tränendrüsen: VI. Menschliche TränendrüseZellforschung, 89
Jones LT (1966)
The lacrimal secretory system and its treatmentAm J Ophthalmol, 62
W. Covey, P. Perillie, S. Finch (1971)
The Origin of Tear Lysozyme 1Proceedings of the Society for Experimental Biology and Medicine, 137
L. Minton (1965)
Paralimbal ring keratitis and absence of lysozyme.American journal of ophthalmology, 60 3
N. Haeringen, E. Glasius (1974)
Enzymatic studies in lacrimal secretion.Experimental eye research, 19 2
Seal DV Mackie IA (1976)
Quantitative tear lysozyme activity in units of activity per microlitreBr J Ophthalmol, 60
A. Fleming (1922)
On a Remarkable Bacteriolytic Element Found in Tissues and SecretionsProceedings of The Royal Society B: Biological Sciences, 93
J. Egeberg, Q. Jensen (1969)
THE ULTRASTRUCTURE OF THE ACINI OF THE HUMAN LACRIMAL GLANDActa Ophthalmologica, 47
T. Mason, R. Phifer, S. Spicer, R. Swallow, R. Dreskin (1969)
AN IMMUNOGLOBULIN-ENZYME BRIDGE METHOD FOR LOCALIZING TISSUE ANTIGENSJournal of Histochemistry and Cytochemistry, 17
Fleming A (1932)
LysozymeProc R Soc Med, 26
A. Sapse, B. Bonavida, W. Stone, E. Sercarz (1968)
Human tear lysozyme. 3. Preliminary study on lysozyme levels in subjects with smog eye irritation.American journal of ophthalmology, 66 1
D. Mason, C. Taylor (1975)
The distribution of muramidase (lysozyme) in human tissues.Journal of Clinical Pathology, 28
I. Mackie, D. Seal (1976)
Quantitative tear lysozyme assay in units of activity per microlitre.British Journal of Ophthalmology, 60
L. Jones (1966)
The lacrimal secretory system and its treatment.Journal of the All-India Ophthalmological Society, 14 5
E. Regan (1950)
The Lysozyme Content of TearsAmerican Journal of Ophthalmology, 33
D. Mcclelland, R. Furth (1975)
In vitro synthesis of lysozyme by human and mouse tissues and leucocytes.Immunology, 28 6
W. Mcewen, S. Kimura (1955)
Filter-paper electrophoresis of tears. I. Lysozyme and its correlation with keratoconjunctivitis sicca.American journal of ophthalmology, 39 2 Pt 2
M. Allen, P. Wright, L. Reid (1972)
The Human Lacrimal Gland: A Histochemical and Organ Culture Study of the Secretory CellsArchives of Ophthalmology, 88
Frater W Mepham BL (1979)
The use of proteolytic enzymes to improve immunoglobulin staining by the PAP techniqueHistochem J, 11
O. Bijsterveld (1969)
Diagnostic Tests in the Sicca SyndromeArchives of Ophthalmology, 82
Gregory J Curran RC (1977)
The unmasking of antigens in paraffin sections of tissue by trypsinExperientia, 33
Abstract • In an immunohistochemical study of the human lacrimal glands and other orbital adnexa, lysozyme was found to be present in the major and accessory lacrimal glands but absent from Meibomian glands and conjunctival epithelium. Almost all acinar and tubular cells in major and accessory lacrimal glands contain lysozyme, although occasional cells show diminished staining for lysozyme, probably because of secretion. Only one secretory lacrimal tubuloacinar cell type is demonstrable, although two types previously have been described. Lacrimal duct cells do not contain lysozyme. The findings of this study support the concept that the tubuloacinar cells of the main and accessory lacrimal glands are the sole source of the lysozyme secreted into tears. References 1. McClelland DBL, van Furth R: In vitro synthesis of lysozyme by human and mouse tissues and leukocytes . Immunology 1975;28:1099-1114. 2. Fleming A: On a remarkable bacteriolytic element found in tissues and secretions . Proc R Soc B 1922;93:306-317.Crossref 3. Fleming A: Lysozyme . Proc R Soc Med 1932;26:71-84. 4. Sapse AT, Bonavida B, Stone W: Human tear lysozyme: III. Preliminary study on lysozyme levels in subjects with smog eye irritation . Am J Ophthalmol 1968;66:76-80. 5. Minton LR: Paralimbal ring keratitis and absence of lysozyme . Am J Ophthalmol 1965; 60:532-535. 6. Regan E: The lysozyme content of tears . Am J Ophthalmol 1950;33:600-605. 7. McEwan WK, Kimura SJ: Filterpaper electrophoresis of tears: I. Lysozyme and its correlation with keratoconjunctivitis sicca . Am J Ophthalmol 1955;39:200-202. 8. Van Bijsterveld OP: Diagnostic tests in the sicca syndrome . Arch Ophthalmol 1969;82:10-14.Crossref 9. Mackie IA, Seal DV: Quantitative tear lysozyme activity in units of activity per microlitre . Br J Ophthalmol 1976;60:70-74.Crossref 10. Allen M, Wright P, Reid L: The human lacrimal gland: A histochemical and organ culture study of the secretory cells . Arch Ophthalmol 1972;88:493-497.Crossref 11. Mason DY, Taylor CR: The distribution of muramidase (lysozyme) in human tissues . J Clin Pathol 1975;28:124-132.Crossref 12. Mason TE, Phifer RF, Spicer SS, et al: An immunoglobulin-enzyme bridge method for localizing tissue antigens . J Histochem Cytochem 1969;17:563-569.Crossref 13. Curran RC, Gregory J: The unmasking of antigens in paraffin sections of tissue by trypsin . Experientia 1977;33:1400-1401.Crossref 14. Mepham BL, Frater W, Mitchell BS: The use of proteolytic enzymes to improve immunoglobulin staining by the PAP technique . Histochem J 1979;11:345-358.Crossref 15. Jones LT: The lacrimal secretory system and its treatment . Am J Ophthalmol 1966;62:47-60. 16. Van Haeringen NJ, Glasius E: Enzymatic studies in lacrimal secretion . Exp Eye Res 1974;19:135-139.Crossref 17. Kühnel W: Vergleichende histologische, histochemiche und elektronmikroskopische Untersuchungen an Tränendrüsen: VI. Menschliche Tränendrüse . Zellforschung 1968;89:550-572.Crossref 18. Egeberg J, Jensen OA: The ultrastructure of the acini of the human lacrimal gland . Acta Ophthalmol 1969;47:400-410.Crossref 19. Covey W, Perille P, Finch SC: The origin of tear lysozyme . Proc Soc Exp Biol Med 1971; 137:1362-1363.Crossref
Archives of Ophthalmology – American Medical Association
Published: Oct 1, 1981
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