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Electrophysiologic Findings in Bilateral Optic Nerve Hypoplasia

Electrophysiologic Findings in Bilateral Optic Nerve Hypoplasia Abstract • Electrophysiologic studies were performed on 17 patients with bilateral optic nerve hypoplasia. Since most patients were infants, the diffuse light visualevoked response was more helpful than the visual-evoked response obtained with pattern stimulation. In children over 1 year of age, the amplitude with diffuse light stimulation correlated well with other clinical measurements used to assess visual function. Before 6 months of age, it correlated better with visual prognosis than did clinical analysis. Photopic and scotopic electroretinographic measurements were normal in all except two in whom the scotopic b wave was supernormal. References 1. Whinery RD, Blodi FC: Hypoplasia of the optic nerve: A clinical and histopathologic correlation . Trans Am Acad Ophthalmol Otolaryngol 1963;67:733-738. 2. Ellenberger C, Runyan TE: Holoprosencephaly with hypoplasia of the optic nerves, dwarfism and agenesis of septum pellucidum . Am J Ophthalmol 1970;70:960-967. 3. Jan JE, Robinson GG, Kinnis C, et al: Blindness due to optic nerve atrophy and hypoplasia in children: An epidemiologic study . Dev Med Child Neurol 1977;19:353-363.Crossref 4. Walton DS, Robb RM: Optic nerve hypoplasia . Arch Ophthalmol 1980;84:572-578.Crossref 5. Edwards WE, Layden WE: Optic nerve hypoplasia . Am J Ophthalmol 1970;70:950-959. 6. Bjork A, Carrell CG, Laurell U: Bilateral optic nerve hypoplasia with normal visual acuity . Am J Ophthalmol 1978;86:524-529. 7. Gardner HB, Irvine AR: Optic nerve hypoplasia with good visual acuity . Arch Ophthalmol 1972;88:255-258.Crossref 8. Wilson WB: Visual-evoked response differentiation of ischemic optic neuritis from the optic neuritis of multiple sclerosis . Am J Ophthalmol 1978;86:530-535. 9. Marmor MF: Corneal electroretinograms in children without sedation . J Pediatr Ophthalmol 1970;13:112-118. 10. DeMorsier G: Median cranioencephalic dysraphias and olfacto-genital dysplasia . World Neurol 1962;3:485-503. 11. McKinna AJ: Quinine-induced hypoplasia of the optic nerve . Can J Ophthalmol 1966;1:261-266. 12. Petersen RA, Walton DS: Optic nerve hypoplasia with good visual acuity and visual field defects . Arch Ophthalmol 1977;95:254-258.Crossref 13. Mosier MA, Lieberman MF, Green WR, et al: Hypoplasia of the optic nerve . Arch Ophthalmol 1978;96:1437-1442.Crossref 14. Jacobson JG, Gestring CF: Centrifugal influences upon the electroretinogram . Ann NY Acad Sci 1958;74:362-371.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Electrophysiologic Findings in Bilateral Optic Nerve Hypoplasia

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References (18)

Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1981.03930011028009
Publisher site
See Article on Publisher Site

Abstract

Abstract • Electrophysiologic studies were performed on 17 patients with bilateral optic nerve hypoplasia. Since most patients were infants, the diffuse light visualevoked response was more helpful than the visual-evoked response obtained with pattern stimulation. In children over 1 year of age, the amplitude with diffuse light stimulation correlated well with other clinical measurements used to assess visual function. Before 6 months of age, it correlated better with visual prognosis than did clinical analysis. Photopic and scotopic electroretinographic measurements were normal in all except two in whom the scotopic b wave was supernormal. References 1. Whinery RD, Blodi FC: Hypoplasia of the optic nerve: A clinical and histopathologic correlation . Trans Am Acad Ophthalmol Otolaryngol 1963;67:733-738. 2. Ellenberger C, Runyan TE: Holoprosencephaly with hypoplasia of the optic nerves, dwarfism and agenesis of septum pellucidum . Am J Ophthalmol 1970;70:960-967. 3. Jan JE, Robinson GG, Kinnis C, et al: Blindness due to optic nerve atrophy and hypoplasia in children: An epidemiologic study . Dev Med Child Neurol 1977;19:353-363.Crossref 4. Walton DS, Robb RM: Optic nerve hypoplasia . Arch Ophthalmol 1980;84:572-578.Crossref 5. Edwards WE, Layden WE: Optic nerve hypoplasia . Am J Ophthalmol 1970;70:950-959. 6. Bjork A, Carrell CG, Laurell U: Bilateral optic nerve hypoplasia with normal visual acuity . Am J Ophthalmol 1978;86:524-529. 7. Gardner HB, Irvine AR: Optic nerve hypoplasia with good visual acuity . Arch Ophthalmol 1972;88:255-258.Crossref 8. Wilson WB: Visual-evoked response differentiation of ischemic optic neuritis from the optic neuritis of multiple sclerosis . Am J Ophthalmol 1978;86:530-535. 9. Marmor MF: Corneal electroretinograms in children without sedation . J Pediatr Ophthalmol 1970;13:112-118. 10. DeMorsier G: Median cranioencephalic dysraphias and olfacto-genital dysplasia . World Neurol 1962;3:485-503. 11. McKinna AJ: Quinine-induced hypoplasia of the optic nerve . Can J Ophthalmol 1966;1:261-266. 12. Petersen RA, Walton DS: Optic nerve hypoplasia with good visual acuity and visual field defects . Arch Ophthalmol 1977;95:254-258.Crossref 13. Mosier MA, Lieberman MF, Green WR, et al: Hypoplasia of the optic nerve . Arch Ophthalmol 1978;96:1437-1442.Crossref 14. Jacobson JG, Gestring CF: Centrifugal influences upon the electroretinogram . Ann NY Acad Sci 1958;74:362-371.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jun 1, 1981

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