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Commonly Used Intraocular Medications and the Corneal Endothelium

Commonly Used Intraocular Medications and the Corneal Endothelium Abstract • Forty-one cats had balanced salt solution, chymotrypsin, epinephrine hydrochloride with preservatives in varying concentrations, acetylcholine chloride, and carbachol injected intracamerally to determine the toxic effects on the endothelium. Specular microscopy was performed both before and after injection, and for each of the medications, the cell densities were compared with the results obtained with the balanced salt solution. The mean postinjection density as compared with the preinjection density for the medications varied between 98% and 108%, and there were no statistically significant differences between each medication group and the balanced salt solution results. From the results of this study, it is believed that when indicated, these medications probably do not produce substantial toxic effects on the corneal endothelium. References 1. Hull DS, Chemotti T, Edelhauser HF, et al: Effect of epinephrine on the corneal endothelium . Am J Ophthalmol 79:245-250, 1975. 2. Van Horn DL, Sendele DD, Seideman S, et al: Regenerative capacity of the corneal endothelium in rabbit and cat . Invest Ophthalmol Vis Sci 16:597-613, 1977. 3. Olson RJ: Air and the corneal endothelium . Arch Ophthalmol 98:1283-1284, 1980.Crossref 4. Olson RJ, Kolodner H: Intraocular lens implantation in cats. Ann Ophthalmol, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Commonly Used Intraocular Medications and the Corneal Endothelium

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1980.01020041076017
Publisher site
See Article on Publisher Site

Abstract

Abstract • Forty-one cats had balanced salt solution, chymotrypsin, epinephrine hydrochloride with preservatives in varying concentrations, acetylcholine chloride, and carbachol injected intracamerally to determine the toxic effects on the endothelium. Specular microscopy was performed both before and after injection, and for each of the medications, the cell densities were compared with the results obtained with the balanced salt solution. The mean postinjection density as compared with the preinjection density for the medications varied between 98% and 108%, and there were no statistically significant differences between each medication group and the balanced salt solution results. From the results of this study, it is believed that when indicated, these medications probably do not produce substantial toxic effects on the corneal endothelium. References 1. Hull DS, Chemotti T, Edelhauser HF, et al: Effect of epinephrine on the corneal endothelium . Am J Ophthalmol 79:245-250, 1975. 2. Van Horn DL, Sendele DD, Seideman S, et al: Regenerative capacity of the corneal endothelium in rabbit and cat . Invest Ophthalmol Vis Sci 16:597-613, 1977. 3. Olson RJ: Air and the corneal endothelium . Arch Ophthalmol 98:1283-1284, 1980.Crossref 4. Olson RJ, Kolodner H: Intraocular lens implantation in cats. Ann Ophthalmol, to be published.

Journal

Archives of Ophthalmology – American Medical Association

Published: Dec 1, 1980

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