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Treatment of Vaccinial Keratitis With Trifluorothymidine

Treatment of Vaccinial Keratitis With Trifluorothymidine Abstract • The efficacy of trifluorothymidine was compared with idoxuridine on a blind basis by noting the effect of topical administration of the drugs on the severity of vaccinial keratitis induced in rabbits. Trifluorothymidine was found to be substantially more effective, and was well tolerated. In addition, positive viral cultures after the treatment period were substantially reduced in the trifluorothymidine groups when compared with the idoxuridine or control groups. References 1. Jones BR, Khalof M, Al Mussaini MV: Therapeutic considerations in ocular vaccinia . Trans Ophthalmol Soc UK 83:613-631, 1964. 2. Bonnet P, Bonamour G: Vaccine oculaire professionnelle . Bull Soc Ophthalmol Fr 425-427, 1955. 3. Hyndiuk RA, Okumoto MA, Damiano RE, et al: Treatment of vaccinial keratitis with vidarabine . Arch Ophthalmol 94:1363-1364, 1976.Crossref 4. Kaufman HE, Heidelberger C: Therapeutic antiviral action of 5-trifluoromethyl-2-deoxyuridine, herpes simplex keratitis . Science 145:585-586, 1964.Crossref 5. Hyndiuk RA, Kaufman HE: Newer compounds in therapy of herpes simplex keratitis . Arch Ophthalmol 78:600-605, 1967.Crossref 6. Wellings PC, Awdry PN, Bors FH, et al: Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers . Am J Ophthalmol 73:932-942, 1972. 7. Allen LB, Sidwell RW: Target organ treatment of neurotropic virus diseases: Efficacy as a chemotherapeutic tool and comparison of activity of adenine arabinoside, cytosine arabinoside, idoxuridine, and trifluorothymidine . Antimicrob Agents Chemother 2:229-233, 1972.Crossref 8. Ellis PP, Winograd LA: Ocular vaccinia: A specific treatment . Arch Ophthalmol 68:600-609, 1962.Crossref 9. Fulginiti VA, Winograd LA, Jackson M, et al: Therapy of experimental vaccinial keratitis . Arch Ophthalmol 74:539-544, 1965.Crossref 10. Jones BR, Galbraith JEK: Vaccinial keratitis treated with interferon . Lancet 1:875-879, 1962.Crossref 11. Jack MK, Sorenson RW: Vaccinial keratitis treated with IDU . Arch Ophthalmol 69:730-732, 1963.Crossref 12. Kaufman HE, Nesburn AB, Maloney ED: Cure of vaccinia infection by 5-iodo-2 deoxyuridine . Virology 18:567-569, 1962.Crossref 13. Lepri G, Parducci F: Iodo-deoxyuridine in experimental vaccinial keratitis . Ann Ottal 88:443-447, 1962. 14. Heidelberger C, Parsons DG, Remy DC: Synthesis of 5-trifluoromethyluracil and 5-trifluoromethyl-2 deoxyuridine . J Med Chem 7:1-5, 1964.Crossref 15. Sugar J, Varnell E, Centifanto Y, et al: Trifluorothymidine treatment of herpetic iritis in rabbits and ocular penetration . Invest Ophthalmol 12:532-534, 1973. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Treatment of Vaccinial Keratitis With Trifluorothymidine

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1976.03910040559015
Publisher site
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Abstract

Abstract • The efficacy of trifluorothymidine was compared with idoxuridine on a blind basis by noting the effect of topical administration of the drugs on the severity of vaccinial keratitis induced in rabbits. Trifluorothymidine was found to be substantially more effective, and was well tolerated. In addition, positive viral cultures after the treatment period were substantially reduced in the trifluorothymidine groups when compared with the idoxuridine or control groups. References 1. Jones BR, Khalof M, Al Mussaini MV: Therapeutic considerations in ocular vaccinia . Trans Ophthalmol Soc UK 83:613-631, 1964. 2. Bonnet P, Bonamour G: Vaccine oculaire professionnelle . Bull Soc Ophthalmol Fr 425-427, 1955. 3. Hyndiuk RA, Okumoto MA, Damiano RE, et al: Treatment of vaccinial keratitis with vidarabine . Arch Ophthalmol 94:1363-1364, 1976.Crossref 4. Kaufman HE, Heidelberger C: Therapeutic antiviral action of 5-trifluoromethyl-2-deoxyuridine, herpes simplex keratitis . Science 145:585-586, 1964.Crossref 5. Hyndiuk RA, Kaufman HE: Newer compounds in therapy of herpes simplex keratitis . Arch Ophthalmol 78:600-605, 1967.Crossref 6. Wellings PC, Awdry PN, Bors FH, et al: Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers . Am J Ophthalmol 73:932-942, 1972. 7. Allen LB, Sidwell RW: Target organ treatment of neurotropic virus diseases: Efficacy as a chemotherapeutic tool and comparison of activity of adenine arabinoside, cytosine arabinoside, idoxuridine, and trifluorothymidine . Antimicrob Agents Chemother 2:229-233, 1972.Crossref 8. Ellis PP, Winograd LA: Ocular vaccinia: A specific treatment . Arch Ophthalmol 68:600-609, 1962.Crossref 9. Fulginiti VA, Winograd LA, Jackson M, et al: Therapy of experimental vaccinial keratitis . Arch Ophthalmol 74:539-544, 1965.Crossref 10. Jones BR, Galbraith JEK: Vaccinial keratitis treated with interferon . Lancet 1:875-879, 1962.Crossref 11. Jack MK, Sorenson RW: Vaccinial keratitis treated with IDU . Arch Ophthalmol 69:730-732, 1963.Crossref 12. Kaufman HE, Nesburn AB, Maloney ED: Cure of vaccinia infection by 5-iodo-2 deoxyuridine . Virology 18:567-569, 1962.Crossref 13. Lepri G, Parducci F: Iodo-deoxyuridine in experimental vaccinial keratitis . Ann Ottal 88:443-447, 1962. 14. Heidelberger C, Parsons DG, Remy DC: Synthesis of 5-trifluoromethyluracil and 5-trifluoromethyl-2 deoxyuridine . J Med Chem 7:1-5, 1964.Crossref 15. Sugar J, Varnell E, Centifanto Y, et al: Trifluorothymidine treatment of herpetic iritis in rabbits and ocular penetration . Invest Ophthalmol 12:532-534, 1973.

Journal

Archives of Ophthalmology – American Medical Association

Published: Oct 1, 1976

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