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A Model for Steroid Effects in Herpes Keratitis

A Model for Steroid Effects in Herpes Keratitis Abstract Dextran-Blue 2000 was used as a marker to determine the effect of steroids on large molecule transfer through the cornea. In superficially scarified corneas topically applied steroids greatly enhanced the transfer of this chromophore through the cornea in the in vivo state, but had little effect in vitro. This implies that the steroid effect is an active process. Since herpes simplex virus is approximately the same molecular weight and configuration as the chromophore used, this study explains one aspect of how steroids may be detrimental when used in the presence of this virus. References 1. Jones BR: Herpes keratitis and its pathogenesis . Proc R Soc Med 51:917-924, 1958. 2. Kilbourne D, Horsfall F: Cortisone effects on viral multiplication . Proc Soc Exper Biol Med 76:116-118, 1951.Crossref 3. Jawetz E: Effect of steroids on herpes simplex keratitis in the rabbit . J Immunol 83:486-490, 1959. 4. Kimura SJ: Effect of steroids on herpes simplex keratitis . Am J Ophthalmol 51:945-948, 1961. 5. Kaufman HE, Maloney E: Herpes keratitis and the effect of steroids . Arch Ophthalmol 66:99-102, 1961.Crossref 6. Thomas C: Herpes keratitis and steroids . Am J Ophthalmol 60:204-217, 1965. 7. Easterbrook M, Wilkie J, Coleman V, et al: The effect of topical steroids on the susceptibility of immune animals to reinoculation with herpes simplex virus . Invest Ophthalmol 12:181-184, 1973. 8. Kimura SJ, Diaz-Bonnet V, Okumoto M, et al: The effect of steroid hormones on experimental herpes simplex keratitis: A clinical histopathologic and histochemical study . Am J Ophthalmol 51:945-948, 1961. 9. Castor CW: Corticoid suppression of mucopolysaccharide formation . J Lab Clin Med 60:788-795, 1962. 10. Anseth A: Glycosaminoglycans in corneal regeneration . Exp Eye Res 1:122-129, 1961.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

A Model for Steroid Effects in Herpes Keratitis

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1975.01010020716009
Publisher site
See Article on Publisher Site

Abstract

Abstract Dextran-Blue 2000 was used as a marker to determine the effect of steroids on large molecule transfer through the cornea. In superficially scarified corneas topically applied steroids greatly enhanced the transfer of this chromophore through the cornea in the in vivo state, but had little effect in vitro. This implies that the steroid effect is an active process. Since herpes simplex virus is approximately the same molecular weight and configuration as the chromophore used, this study explains one aspect of how steroids may be detrimental when used in the presence of this virus. References 1. Jones BR: Herpes keratitis and its pathogenesis . Proc R Soc Med 51:917-924, 1958. 2. Kilbourne D, Horsfall F: Cortisone effects on viral multiplication . Proc Soc Exper Biol Med 76:116-118, 1951.Crossref 3. Jawetz E: Effect of steroids on herpes simplex keratitis in the rabbit . J Immunol 83:486-490, 1959. 4. Kimura SJ: Effect of steroids on herpes simplex keratitis . Am J Ophthalmol 51:945-948, 1961. 5. Kaufman HE, Maloney E: Herpes keratitis and the effect of steroids . Arch Ophthalmol 66:99-102, 1961.Crossref 6. Thomas C: Herpes keratitis and steroids . Am J Ophthalmol 60:204-217, 1965. 7. Easterbrook M, Wilkie J, Coleman V, et al: The effect of topical steroids on the susceptibility of immune animals to reinoculation with herpes simplex virus . Invest Ophthalmol 12:181-184, 1973. 8. Kimura SJ, Diaz-Bonnet V, Okumoto M, et al: The effect of steroid hormones on experimental herpes simplex keratitis: A clinical histopathologic and histochemical study . Am J Ophthalmol 51:945-948, 1961. 9. Castor CW: Corticoid suppression of mucopolysaccharide formation . J Lab Clin Med 60:788-795, 1962. 10. Anseth A: Glycosaminoglycans in corneal regeneration . Exp Eye Res 1:122-129, 1961.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Sep 1, 1975

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