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Granulomatous Choroiditis in a Case of Disseminated Histoplasmosis: Histologic Demonstration of Histoplasma capsulatum in Choroidal Lesions

Granulomatous Choroiditis in a Case of Disseminated Histoplasmosis: Histologic Demonstration of... Abstract The identification of Histoplasma capsulatum in choroidal lesions of a fatal human case of disseminated histoplasmosis is described. Aside from granulomatous chorioretinitis, this patient had Addison's disease with bilateral adrenal calcification secondary to histoplasmosis of the adrenal glands and a cell-mediated immune deficiency. The fungus was isolated from bone marrow, skin, lymph nodes, and the cerebrospinal fluid during life and from the brain postmortem. The organisms observed within the choroid were identical to those in other tissues from which H capsulatum was isolated. The presence of H capsulatum in a granulomatous choroiditis fills a void in our knowledge about ocular histoplasmosis. References 1. Ajello L, Chick EW, Furcolow ML (eds): Histoplasmosis: Proceedings of the Second National Conference . Springfield, Ill, Charles C Thomas Publisher, 1971. 2. Fetter BF, Klintworth GK, Hendry WS: Mycoses of the Central Nervous System . Baltimore, Williams & Wilkins Co, 1967. 3. Schwartz J: Histoplasmosis , in Baker RD, et al: Human Infectious With Fungi, Actinomycetes and Algae . New York, Springer-Verlag, 1971, chap 4. 4. Reid JD, et al: Systemic histoplasmosis diagnosed before death and produced experimentally in guinea pigs . J Lab Clin Med 27:419-434, 1942. 5. Spaeth GL: Absence of so-called Histoplasma uveitis in 134 cases of proven histoplasmosis . Arch Ophthalmol 77:41-44, 1967.Crossref 6. Hoefnagels KLJ, Pijers PM: Histoplasma capsulatum in a human eye . Am J Ophthalmol 63:715-723, 1967. 7. Day R: Experimental ocular histoplasmosis . Am J Ophthalmol 32:1317-1330, 1949. 8. Woods AC, Wahlen HE: The probable role of benign histoplasmosis in the etiology of granulomatous uveitis . Am J Ophthalmol 49:205-220, 1960. 9. Krause AC, Hopkins WG: Ocular manifestations of histoplasmosis . Am J Ophthalmol 34:564-566, 1951 10. Gass JDM, Wilkinson CP: Follow-up study of presumed ocular histoplasmosis . Trans Am Acad Ophthalmol Otolaryngol 76:672-693, 1972. 11. Krill AE, et al: Multifocal inner choroiditis . Trans Am Acad Ophthalmol Otolaryngol 73:222-245, 1969. 12. Giles CL, Falls HF: Further evaluation of amphotericin-B therapy in presumptive histoplasmosis chorioretinitis . Am J Ophthalmol 51:588-598, 1961. 13. Schlaegel TF Jr, Weber JC: Follow-up study of presumed histoplasmic choroiditis . Am J Ophthalmol 71:1192-1195, 1971. 14. Van Metre TE Jr, Maumenee AE: Specific ocular lesions in patients with evidence of histoplasmosis . Arch Ophthalmol 71:314-324, 1964.Crossref 15. Cooper RA Jr, Goldstein E: Histoplasmosis of the central nervous system . Am J Med 35:45-57, 1963.Crossref 16. Rubin H, et al: The course and prognosis of histoplasmosis . Am J Med 27:278-288, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Granulomatous Choroiditis in a Case of Disseminated Histoplasmosis: Histologic Demonstration of Histoplasma capsulatum in Choroidal Lesions

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References (18)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1973.01000050047009
Publisher site
See Article on Publisher Site

Abstract

Abstract The identification of Histoplasma capsulatum in choroidal lesions of a fatal human case of disseminated histoplasmosis is described. Aside from granulomatous chorioretinitis, this patient had Addison's disease with bilateral adrenal calcification secondary to histoplasmosis of the adrenal glands and a cell-mediated immune deficiency. The fungus was isolated from bone marrow, skin, lymph nodes, and the cerebrospinal fluid during life and from the brain postmortem. The organisms observed within the choroid were identical to those in other tissues from which H capsulatum was isolated. The presence of H capsulatum in a granulomatous choroiditis fills a void in our knowledge about ocular histoplasmosis. References 1. Ajello L, Chick EW, Furcolow ML (eds): Histoplasmosis: Proceedings of the Second National Conference . Springfield, Ill, Charles C Thomas Publisher, 1971. 2. Fetter BF, Klintworth GK, Hendry WS: Mycoses of the Central Nervous System . Baltimore, Williams & Wilkins Co, 1967. 3. Schwartz J: Histoplasmosis , in Baker RD, et al: Human Infectious With Fungi, Actinomycetes and Algae . New York, Springer-Verlag, 1971, chap 4. 4. Reid JD, et al: Systemic histoplasmosis diagnosed before death and produced experimentally in guinea pigs . J Lab Clin Med 27:419-434, 1942. 5. Spaeth GL: Absence of so-called Histoplasma uveitis in 134 cases of proven histoplasmosis . Arch Ophthalmol 77:41-44, 1967.Crossref 6. Hoefnagels KLJ, Pijers PM: Histoplasma capsulatum in a human eye . Am J Ophthalmol 63:715-723, 1967. 7. Day R: Experimental ocular histoplasmosis . Am J Ophthalmol 32:1317-1330, 1949. 8. Woods AC, Wahlen HE: The probable role of benign histoplasmosis in the etiology of granulomatous uveitis . Am J Ophthalmol 49:205-220, 1960. 9. Krause AC, Hopkins WG: Ocular manifestations of histoplasmosis . Am J Ophthalmol 34:564-566, 1951 10. Gass JDM, Wilkinson CP: Follow-up study of presumed ocular histoplasmosis . Trans Am Acad Ophthalmol Otolaryngol 76:672-693, 1972. 11. Krill AE, et al: Multifocal inner choroiditis . Trans Am Acad Ophthalmol Otolaryngol 73:222-245, 1969. 12. Giles CL, Falls HF: Further evaluation of amphotericin-B therapy in presumptive histoplasmosis chorioretinitis . Am J Ophthalmol 51:588-598, 1961. 13. Schlaegel TF Jr, Weber JC: Follow-up study of presumed histoplasmic choroiditis . Am J Ophthalmol 71:1192-1195, 1971. 14. Van Metre TE Jr, Maumenee AE: Specific ocular lesions in patients with evidence of histoplasmosis . Arch Ophthalmol 71:314-324, 1964.Crossref 15. Cooper RA Jr, Goldstein E: Histoplasmosis of the central nervous system . Am J Med 35:45-57, 1963.Crossref 16. Rubin H, et al: The course and prognosis of histoplasmosis . Am J Med 27:278-288, 1959.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1973

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