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C. Braekevelt, M. Hollenberg (1970)
Development of the retinal pigment epithelium, choriocapillaris and Bruch's membrane in the albino rat.Experimental eye research, 9 1
Thomas Weidman, Toichiro Kuwabara (1969)
Development of the rat retina.Investigative ophthalmology, 8 1
W. Spencer, M. Hogan (1960)
Ocular Manifestations of Chédiak-Higashi Syndrome*: Report of a Case with Histopathologic Examination of Ocular TissuesAmerican Journal of Ophthalmology, 50
Moyer F (1961)
The Structure of the Eye
G. Padgett, C. Reiquam, J. Gorham, J. Henson, C. O'mary (1967)
Comparative studies of the Chediak-Higashi syndrome.The American journal of pathology, 51 4
Hogan MJ Spencer WH (1960)
Ocular manifestations of Chediak-Higashi syndromeAmer J Ophthal, 50
Leeson TS (1968)
The outer layers of the optic cup and associated tissuesCanad J Ophthal, 3
K. Porter, E. Yamada (1960)
STUDIES ON THE ENDOPLASMIC RETICULUMThe Journal of Biophysical and Biochemical Cytology, 8
Yamada E Porter KR (1960)
Studies of the endoplasmic reticulum: V. Its form and differentiation in pigment epithelial cells of the frog retinaJ Biophys Biochem Cytol, 8
J. Dowling, R. Sidman (1962)
INHERITED RETINAL DYSTROPHY IN THE RATThe Journal of Cell Biology, 14
T. Kuwabara, R. Gorn (1968)
Retinal damage by visible light. An electron microscopic study.Archives of ophthalmology, 79 1
A. Grignolo, N. Orzalesi, R. Castellazzo, P. Vittone (1969)
Retinal damage by visible light in albino rats. An electron microscope study.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 157 1
L. Zimmerman, A. Eastham (1959)
Acid mucopolysaccharide in the retinal pigment epithelium and visual cell layer of the developing mouse eye.American journal of ophthalmology, 47 1 Pt 2
T. Dunn (1954)
The importance of differences in morphology in inbred strains.Journal of the National Cancer Institute, 15 3
K. Tansley (1951)
Hereditary Degeneration of the Mouse Retina *British Journal of Ophthalmology, 35
Moyer F (1963)
Genetic effects on melanosome fine structure and ontogeny in normal and malignant cellsAnn NY Acad Sci, 100
C. Braekevelt, M. Hollenberg (1970)
The development of the retina of the albino rat.The American journal of anatomy, 127 3
A. Zelickson, D. Windhorst, J. White, R. Good (1967)
The Chediak-Higashi syndrome: formation of giant melanosomes and the basis of hypopigmentation.The Journal of investigative dermatology, 49 6
A. Breathnah, L. Wyllie (1966)
Ultrastructure of retinal pigment epithelium of the human fetus.Journal of ultrastructure research, 16 5
F. Moyer (1963)
GENETIC EFFECTS ON MELANOSOME FINE STRUCTURE AND ONTOGENY IN NORMAL AND MALIGNANT CELLS *Annals of the New York Academy of Sciences, 100
J. Dowling, I. Gibbons (1962)
THE FINE STRUCTURE OF THE PIGMENT EPITHELIUM IN THE ALBINO RATThe Journal of Cell Biology, 14
Kuwabara T (1970)
Retinal recovery from lightAmer J Ophthal, 79
H. Hansson (1970)
A histochemical study of oxidative enzymes in rat retina damaged by visible light.Experimental eye research, 9 2
M. Rodrigues, R. Streett, B. Highman (1971)
Partial ocular albinism in Mystromys albicaudatus (African white-tailed rat).Archives of pathology, 92 3
Noell WK (1966)
Functional and structural manifestations of a damaging effect of light upon the rat retinaFed Proc, 25
H. Hansson, P. Sourander (1970)
A lipid histochemical study of the rat retina damaged by visible light.Experimental eye research, 10 1
Abstract In a previous study, partial oculocutaneous albinism observed in a colony of Mystromys albicaudatus was found to be due to a paucity of choroidal pigmentation combined with hypopigmentation of the iris, ciliary, and retinal pigment epithelia. By electron microscopy in the present study, the choroidal cells in the adult were observed to possess large numbers of apparently empty vacuoles and no evidence of early melanogenesis. Melanin granules in both immature and abnormal forms were observed in the neuroepithelial layers. Patchy photoreceptor degeneration was also present in the affected adult animals. The pigment epithelium of the affected animals was abnormal from birth, while the neural retina seemed to be normal up to 1 month of age. Further propagation of this aberrant colony of M albicaudatus should permit future determination of the age at which photoreceptors begin to degenerate. References 1. Rodrigues MM, Streett RP, Highman B: Partial ocular albinism in Mystromys albicaudatus (African white-tailed rat) . Arch Path 92:212-218, 1971. 2. Fine BS, Yanoff M: Ocular Histology: A Text and Atlas, New York, Harper & Row, to be published. 3. Mund ML, Rodrigues MM, Fine BS: Light and electron microscopic observations on the developing pigmented layers of the human eye. Amer J Ophthal, to be published. 4. Dowling JE, Gibbons IR: The fine structure of the pigment epithelium in the albino rat . J Cell Biol 14:459-474, 1962.Crossref 5. Braekevelt CR, Hollenberg MJ: The development of the retina of the albino rat . Amer J Anat 127:281-301, 1970.Crossref 6. Braekevelt CR, Hollenberg MJ: Development of the retinal pigment epithelium, choriocapillaris, and Bruch's membrane in the albino rat . Exp Eye Res 9:124-131, 1970.Crossref 7. Leeson TS: The outer layers of the optic cup and associated tissues . Canad J Ophthal 3:77-96, 1968. 8. Weidman TA, Kuwabara T: Development of the rat retina . Invest Ophthal 8:60-69, 1969. 9. Feeney L, Grieshaber JA, Hogan MJ: Studies on human ocular pigment , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 535. 10. Porter KR, Yamada E: Studies of the endoplasmic reticulum: V. Its form and differentiation in pigment epithelial cells of the frog retina . J Biophys Biochem Cytol 8:181-190, 1960.Crossref 11. Yamada E: The Fine Structure of the pigment epithelium in the turtle eye , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 73. 12. Dowling JE, Gibbons IR: The Effect of vitamin A deficiency on the fine structure of the retina , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 85. 13. Dowling JE, Sidman RL: Inherited retinal dystrophy in the rat . J Cell Biol 14:73-109, 1962.Crossref 14. Kuwabara T, Gorn RA: Retinal damage by visible light: An electron microscopic study . Arch Ophthal 79:69-78, 1968.Crossref 15. Kuwabara T: Retinal recovery from light . Amer J Ophthal 79:187-198, 1970. 16. Noell WK: Functional and structural manifestations of a damaging effect of light upon the rat retina . Fed Proc 25:329-335, 1966. 17. Grignolo A: Retinal damage by visible light in albino rats: An electron microscopic study . Ophthalmologica 157:43-59, 1969.Crossref 18. Hansson H: A histochemical study of oxidative enzymes in rat retina damaged by visible light . Exp Eye Res 9:285-296, 1970.Crossref 19. Hansson H, Sourander P: A lipoid histochemical study of the rat retina damaged by visible light . Exp Eye Res 10:64-70, 1970.Crossref 20. Moyer F: Electron microscopic observations on the origin, development and genetic control of melanin granules in the mouse eye , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 469. 21. Moyer F: Genetic effects on melanosome fine structure and ontogeny in normal and malignant cells . Ann NY Acad Sci 100:584-606, 1963.Crossref 22. Breathnach AS, Wyllie L: Ultrastructure of retinal pigment epithelium of the human fetus . J Ultrastruct Res 16:584-597, 1966.Crossref 23. Spencer WH, Hogan MJ: Ocular manifestations of Chediak-Higashi syndrome . Amer J Ophthal 50:1197-1203, 1960. 24. Padgett GA, Reiquam CW, Gorhan JR, et al: Comparative studies of the Chediak-Higashi syndrome . Amer J Path 51:553-571, 1967. 25. Zelickson AS, Windhorst DR, White JG, et al: The Chediak-Higashi syndrome: Formation of giant melanosomes and the basis of hypopigmentation . J Invest Derm 49:575-581, 1967.Crossref 26. Tansley K: Hereditary degeneration of the mouse retina . Brit J Ophthal 35:573-582, 1951.Crossref 27. Dunn TB: The importance of differences in morphology in inbred strains . J Nat Cancer Inst 15:573-591, 1954. 28. Zimmerman LE, Eastham AB: Acid mucopolysaccharides in the retinal pigment epithelium and visual cell layer of the developing mouse eye . Amer J Ophthal 47:488-497, 1959.
Archives of Ophthalmology – American Medical Association
Published: Mar 1, 1972
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