Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Partial Ocular Albinism in Mystromys albicaudatus (The African White-Tailed Rat): An Electron Microscopic Study

Partial Ocular Albinism in Mystromys albicaudatus (The African White-Tailed Rat): An Electron... Abstract In a previous study, partial oculocutaneous albinism observed in a colony of Mystromys albicaudatus was found to be due to a paucity of choroidal pigmentation combined with hypopigmentation of the iris, ciliary, and retinal pigment epithelia. By electron microscopy in the present study, the choroidal cells in the adult were observed to possess large numbers of apparently empty vacuoles and no evidence of early melanogenesis. Melanin granules in both immature and abnormal forms were observed in the neuroepithelial layers. Patchy photoreceptor degeneration was also present in the affected adult animals. The pigment epithelium of the affected animals was abnormal from birth, while the neural retina seemed to be normal up to 1 month of age. Further propagation of this aberrant colony of M albicaudatus should permit future determination of the age at which photoreceptors begin to degenerate. References 1. Rodrigues MM, Streett RP, Highman B: Partial ocular albinism in Mystromys albicaudatus (African white-tailed rat) . Arch Path 92:212-218, 1971. 2. Fine BS, Yanoff M: Ocular Histology: A Text and Atlas, New York, Harper & Row, to be published. 3. Mund ML, Rodrigues MM, Fine BS: Light and electron microscopic observations on the developing pigmented layers of the human eye. Amer J Ophthal, to be published. 4. Dowling JE, Gibbons IR: The fine structure of the pigment epithelium in the albino rat . J Cell Biol 14:459-474, 1962.Crossref 5. Braekevelt CR, Hollenberg MJ: The development of the retina of the albino rat . Amer J Anat 127:281-301, 1970.Crossref 6. Braekevelt CR, Hollenberg MJ: Development of the retinal pigment epithelium, choriocapillaris, and Bruch's membrane in the albino rat . Exp Eye Res 9:124-131, 1970.Crossref 7. Leeson TS: The outer layers of the optic cup and associated tissues . Canad J Ophthal 3:77-96, 1968. 8. Weidman TA, Kuwabara T: Development of the rat retina . Invest Ophthal 8:60-69, 1969. 9. Feeney L, Grieshaber JA, Hogan MJ: Studies on human ocular pigment , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 535. 10. Porter KR, Yamada E: Studies of the endoplasmic reticulum: V. Its form and differentiation in pigment epithelial cells of the frog retina . J Biophys Biochem Cytol 8:181-190, 1960.Crossref 11. Yamada E: The Fine Structure of the pigment epithelium in the turtle eye , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 73. 12. Dowling JE, Gibbons IR: The Effect of vitamin A deficiency on the fine structure of the retina , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 85. 13. Dowling JE, Sidman RL: Inherited retinal dystrophy in the rat . J Cell Biol 14:73-109, 1962.Crossref 14. Kuwabara T, Gorn RA: Retinal damage by visible light: An electron microscopic study . Arch Ophthal 79:69-78, 1968.Crossref 15. Kuwabara T: Retinal recovery from light . Amer J Ophthal 79:187-198, 1970. 16. Noell WK: Functional and structural manifestations of a damaging effect of light upon the rat retina . Fed Proc 25:329-335, 1966. 17. Grignolo A: Retinal damage by visible light in albino rats: An electron microscopic study . Ophthalmologica 157:43-59, 1969.Crossref 18. Hansson H: A histochemical study of oxidative enzymes in rat retina damaged by visible light . Exp Eye Res 9:285-296, 1970.Crossref 19. Hansson H, Sourander P: A lipoid histochemical study of the rat retina damaged by visible light . Exp Eye Res 10:64-70, 1970.Crossref 20. Moyer F: Electron microscopic observations on the origin, development and genetic control of melanin granules in the mouse eye , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 469. 21. Moyer F: Genetic effects on melanosome fine structure and ontogeny in normal and malignant cells . Ann NY Acad Sci 100:584-606, 1963.Crossref 22. Breathnach AS, Wyllie L: Ultrastructure of retinal pigment epithelium of the human fetus . J Ultrastruct Res 16:584-597, 1966.Crossref 23. Spencer WH, Hogan MJ: Ocular manifestations of Chediak-Higashi syndrome . Amer J Ophthal 50:1197-1203, 1960. 24. Padgett GA, Reiquam CW, Gorhan JR, et al: Comparative studies of the Chediak-Higashi syndrome . Amer J Path 51:553-571, 1967. 25. Zelickson AS, Windhorst DR, White JG, et al: The Chediak-Higashi syndrome: Formation of giant melanosomes and the basis of hypopigmentation . J Invest Derm 49:575-581, 1967.Crossref 26. Tansley K: Hereditary degeneration of the mouse retina . Brit J Ophthal 35:573-582, 1951.Crossref 27. Dunn TB: The importance of differences in morphology in inbred strains . J Nat Cancer Inst 15:573-591, 1954. 28. Zimmerman LE, Eastham AB: Acid mucopolysaccharides in the retinal pigment epithelium and visual cell layer of the developing mouse eye . Amer J Ophthal 47:488-497, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Partial Ocular Albinism in Mystromys albicaudatus (The African White-Tailed Rat): An Electron Microscopic Study

Loading next page...
 
/lp/american-medical-association/partial-ocular-albinism-in-mystromys-albicaudatus-the-african-white-EyLxk0mn70

References (26)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1972.01000020339020
Publisher site
See Article on Publisher Site

Abstract

Abstract In a previous study, partial oculocutaneous albinism observed in a colony of Mystromys albicaudatus was found to be due to a paucity of choroidal pigmentation combined with hypopigmentation of the iris, ciliary, and retinal pigment epithelia. By electron microscopy in the present study, the choroidal cells in the adult were observed to possess large numbers of apparently empty vacuoles and no evidence of early melanogenesis. Melanin granules in both immature and abnormal forms were observed in the neuroepithelial layers. Patchy photoreceptor degeneration was also present in the affected adult animals. The pigment epithelium of the affected animals was abnormal from birth, while the neural retina seemed to be normal up to 1 month of age. Further propagation of this aberrant colony of M albicaudatus should permit future determination of the age at which photoreceptors begin to degenerate. References 1. Rodrigues MM, Streett RP, Highman B: Partial ocular albinism in Mystromys albicaudatus (African white-tailed rat) . Arch Path 92:212-218, 1971. 2. Fine BS, Yanoff M: Ocular Histology: A Text and Atlas, New York, Harper & Row, to be published. 3. Mund ML, Rodrigues MM, Fine BS: Light and electron microscopic observations on the developing pigmented layers of the human eye. Amer J Ophthal, to be published. 4. Dowling JE, Gibbons IR: The fine structure of the pigment epithelium in the albino rat . J Cell Biol 14:459-474, 1962.Crossref 5. Braekevelt CR, Hollenberg MJ: The development of the retina of the albino rat . Amer J Anat 127:281-301, 1970.Crossref 6. Braekevelt CR, Hollenberg MJ: Development of the retinal pigment epithelium, choriocapillaris, and Bruch's membrane in the albino rat . Exp Eye Res 9:124-131, 1970.Crossref 7. Leeson TS: The outer layers of the optic cup and associated tissues . Canad J Ophthal 3:77-96, 1968. 8. Weidman TA, Kuwabara T: Development of the rat retina . Invest Ophthal 8:60-69, 1969. 9. Feeney L, Grieshaber JA, Hogan MJ: Studies on human ocular pigment , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 535. 10. Porter KR, Yamada E: Studies of the endoplasmic reticulum: V. Its form and differentiation in pigment epithelial cells of the frog retina . J Biophys Biochem Cytol 8:181-190, 1960.Crossref 11. Yamada E: The Fine Structure of the pigment epithelium in the turtle eye , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 73. 12. Dowling JE, Gibbons IR: The Effect of vitamin A deficiency on the fine structure of the retina , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 85. 13. Dowling JE, Sidman RL: Inherited retinal dystrophy in the rat . J Cell Biol 14:73-109, 1962.Crossref 14. Kuwabara T, Gorn RA: Retinal damage by visible light: An electron microscopic study . Arch Ophthal 79:69-78, 1968.Crossref 15. Kuwabara T: Retinal recovery from light . Amer J Ophthal 79:187-198, 1970. 16. Noell WK: Functional and structural manifestations of a damaging effect of light upon the rat retina . Fed Proc 25:329-335, 1966. 17. Grignolo A: Retinal damage by visible light in albino rats: An electron microscopic study . Ophthalmologica 157:43-59, 1969.Crossref 18. Hansson H: A histochemical study of oxidative enzymes in rat retina damaged by visible light . Exp Eye Res 9:285-296, 1970.Crossref 19. Hansson H, Sourander P: A lipoid histochemical study of the rat retina damaged by visible light . Exp Eye Res 10:64-70, 1970.Crossref 20. Moyer F: Electron microscopic observations on the origin, development and genetic control of melanin granules in the mouse eye , in Smelser G (ed): The Structure of the Eye . New York, Academic Press, 1961, p 469. 21. Moyer F: Genetic effects on melanosome fine structure and ontogeny in normal and malignant cells . Ann NY Acad Sci 100:584-606, 1963.Crossref 22. Breathnach AS, Wyllie L: Ultrastructure of retinal pigment epithelium of the human fetus . J Ultrastruct Res 16:584-597, 1966.Crossref 23. Spencer WH, Hogan MJ: Ocular manifestations of Chediak-Higashi syndrome . Amer J Ophthal 50:1197-1203, 1960. 24. Padgett GA, Reiquam CW, Gorhan JR, et al: Comparative studies of the Chediak-Higashi syndrome . Amer J Path 51:553-571, 1967. 25. Zelickson AS, Windhorst DR, White JG, et al: The Chediak-Higashi syndrome: Formation of giant melanosomes and the basis of hypopigmentation . J Invest Derm 49:575-581, 1967.Crossref 26. Tansley K: Hereditary degeneration of the mouse retina . Brit J Ophthal 35:573-582, 1951.Crossref 27. Dunn TB: The importance of differences in morphology in inbred strains . J Nat Cancer Inst 15:573-591, 1954. 28. Zimmerman LE, Eastham AB: Acid mucopolysaccharides in the retinal pigment epithelium and visual cell layer of the developing mouse eye . Amer J Ophthal 47:488-497, 1959.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1972

There are no references for this article.