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Treponeme-like Forms in Chimpanzee Aqueous Humor and Cerebrospinal Fluid

Treponeme-like Forms in Chimpanzee Aqueous Humor and Cerebrospinal Fluid Abstract Two hundred and ninety-four specimens of aqueous humor and cerebrospinal fluid from 34 chimpanzees were examined for treponeme-like forms with a direct fluorescent antibody technique. One such form was found in 44 specimens from eight animals having a reactive fluorescent treponemal antibody-absorption (FTA-ABS) test prior to experimental infection, one in 170 specimens from six animals having untreated experimental syphilis of two to three years' duration, and one in 14 specimens of aqueous humor from six animals having pinta of one to two years' duration. None was seen in 49 specimens from animals with non-reactive FTA-ABS tests prior to experimental infection, or in 18 specimens from eight animals examined three to four years following penicillin treatment for experimental syphilis. Seven percent of the fluids examined contained "suspicious" forms which could not definitely be classified as treponemes. References 1. Smith JL, Israel CW: Treponemes in aqueous humor in late seronegative syphilis . Trans Amer Acad Ophthal Otolaryng 72:63-74, 1968. 2. Smith JL: Spirochetes in Late Seronegative Syphilis, Penicillin Notwithstanding . Springfield, Ill, Charles C Thomas Publisher, 1969. 3. Goldman JN, Girard KF: Intraocular treponemes in treated congenital syphilis . Arch Ophthal 78:47-50, 1967.Crossref 4. Goldman JN, Girard KF: Fluorescent antibody staining of treponemes in uveitis . Arch Ophthal 79:716-722, 1968.Crossref 5. Rice NSC, Jones BR, Wilkinson AE: Study of late ocular syphilis . Trans Ophthal Soc UK 88:257-273, 1968. 6. Rice NSC, Dunlop EMC, Jones BR, et al: Demonstration of treponeme-like forms in cases of treated and untreated late syphilis and of treated early syphilis . Brit J Vener Dis 46:1-9, 1970. 7. Dunlop EMC, King AJ, Wilkinson AE: Study of late ocular syphilis . Trans Ophthal Soc UK 88:275-291, 1968. 8. Christman EH, Hamilton RW, Heaton CL, et al: Intraocular treponemes . Arch Ophthal 80:303-307, 1968.Crossref 9. Brown WJ, Kuhn USG, Tolliver EA, et al: Experimental syphilis in the chimpanzee . Brit J Vener Dis 46:198-200, 1970. 10. Kuhn USG, Medina R, Cohen PG, et al: Inoculation pinta in the chimpanzee . Brit J Vener Dis 46:311-312, 1970. 11. Venereal Disease Research Laboratory: A provisional technique for the direct immunofluorescent identification of Treponema pallidum in body fluids and tissue sections in current use at the Venereal Disease Research Laboratory . Atlanta, 1967. 12. Wilkinson AE: Study of late ocular syphilis . Trans Ophthal Soc UK 88:251-256, 1968. 13. Rios Montenegro EN, Nicol WG, Smith JL: Treponema-like forms and artifacts . Amer J Ophthal 68:196-205, 1969. 14. Kuhn USG, Brown WJ, Falcone VH: Sero reactivity of non-human primates in treponemal and nontreponemal antigen tests for syphilis . WHO/ DVT/RES/ 68:137, 1968. 15. Levine BM, Smith JL, Israel CW: Serology of normal primates . Brit J Vener Dis 46:307-310, 1970. 16. Fribourg-Blanc A, Mollaret HH: Natural treponematosis in the African monkey . WHO/VDT/ RES/ 68:135, 1968. 17. Sepetjian M, Guerraz FT, Salussola D: Contribution to the study of the treponeme isolated from monkeys by A. Fribourg-Blanc . WHO/VDT/ RES/ 68:149, 1968. 18. Golden B, Watzke RC, Lindell SS: Treponemal-like organisms in the aqueous of nonsyphilitic patients: An immunologic study . Arch Ophthal 80:727-731, 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Treponeme-like Forms in Chimpanzee Aqueous Humor and Cerebrospinal Fluid

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References (19)

Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1972.01000020335019
Publisher site
See Article on Publisher Site

Abstract

Abstract Two hundred and ninety-four specimens of aqueous humor and cerebrospinal fluid from 34 chimpanzees were examined for treponeme-like forms with a direct fluorescent antibody technique. One such form was found in 44 specimens from eight animals having a reactive fluorescent treponemal antibody-absorption (FTA-ABS) test prior to experimental infection, one in 170 specimens from six animals having untreated experimental syphilis of two to three years' duration, and one in 14 specimens of aqueous humor from six animals having pinta of one to two years' duration. None was seen in 49 specimens from animals with non-reactive FTA-ABS tests prior to experimental infection, or in 18 specimens from eight animals examined three to four years following penicillin treatment for experimental syphilis. Seven percent of the fluids examined contained "suspicious" forms which could not definitely be classified as treponemes. References 1. Smith JL, Israel CW: Treponemes in aqueous humor in late seronegative syphilis . Trans Amer Acad Ophthal Otolaryng 72:63-74, 1968. 2. Smith JL: Spirochetes in Late Seronegative Syphilis, Penicillin Notwithstanding . Springfield, Ill, Charles C Thomas Publisher, 1969. 3. Goldman JN, Girard KF: Intraocular treponemes in treated congenital syphilis . Arch Ophthal 78:47-50, 1967.Crossref 4. Goldman JN, Girard KF: Fluorescent antibody staining of treponemes in uveitis . Arch Ophthal 79:716-722, 1968.Crossref 5. Rice NSC, Jones BR, Wilkinson AE: Study of late ocular syphilis . Trans Ophthal Soc UK 88:257-273, 1968. 6. Rice NSC, Dunlop EMC, Jones BR, et al: Demonstration of treponeme-like forms in cases of treated and untreated late syphilis and of treated early syphilis . Brit J Vener Dis 46:1-9, 1970. 7. Dunlop EMC, King AJ, Wilkinson AE: Study of late ocular syphilis . Trans Ophthal Soc UK 88:275-291, 1968. 8. Christman EH, Hamilton RW, Heaton CL, et al: Intraocular treponemes . Arch Ophthal 80:303-307, 1968.Crossref 9. Brown WJ, Kuhn USG, Tolliver EA, et al: Experimental syphilis in the chimpanzee . Brit J Vener Dis 46:198-200, 1970. 10. Kuhn USG, Medina R, Cohen PG, et al: Inoculation pinta in the chimpanzee . Brit J Vener Dis 46:311-312, 1970. 11. Venereal Disease Research Laboratory: A provisional technique for the direct immunofluorescent identification of Treponema pallidum in body fluids and tissue sections in current use at the Venereal Disease Research Laboratory . Atlanta, 1967. 12. Wilkinson AE: Study of late ocular syphilis . Trans Ophthal Soc UK 88:251-256, 1968. 13. Rios Montenegro EN, Nicol WG, Smith JL: Treponema-like forms and artifacts . Amer J Ophthal 68:196-205, 1969. 14. Kuhn USG, Brown WJ, Falcone VH: Sero reactivity of non-human primates in treponemal and nontreponemal antigen tests for syphilis . WHO/ DVT/RES/ 68:137, 1968. 15. Levine BM, Smith JL, Israel CW: Serology of normal primates . Brit J Vener Dis 46:307-310, 1970. 16. Fribourg-Blanc A, Mollaret HH: Natural treponematosis in the African monkey . WHO/VDT/ RES/ 68:135, 1968. 17. Sepetjian M, Guerraz FT, Salussola D: Contribution to the study of the treponeme isolated from monkeys by A. Fribourg-Blanc . WHO/VDT/ RES/ 68:149, 1968. 18. Golden B, Watzke RC, Lindell SS: Treponemal-like organisms in the aqueous of nonsyphilitic patients: An immunologic study . Arch Ophthal 80:727-731, 1968.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1972

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