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Intraocular Involvement in Burkitt's Lymphoma

Intraocular Involvement in Burkitt's Lymphoma Abstract BURKITT'S lymphoma, which is a poorly differentiated lymphocytic lymphoma1,2 with unique epidemiologic features and a characteristic clinical and histologic pattern, is the most common malignant tumor among children in tropical Africa.3-6 It is also by far the most common of all orbital tumors, regardless of age, in Uganda.7 The tumor often arises in the superior portion of the maxilla and erodes the orbit to such an extent that exophthalmos, which may be extreme, is frequently the outstanding clinical feature and presenting symptom (Fig 1). Other clinical manifestations related to the infiltration of orbital soft tissues by the tumor may include chemosis and edema of the lid, tortuosity of retinal vessels, corneal anesthesia, exposure keratitis, corneal ulcers, and panophthalmitis.3-9 Recently we had an opportunity to study an eye that was enucleated from a patient with Burkitt's lymphoma, one in which there was massive invasion of the globe References 1. O'Conor GT, Davies JNP: Malignant tumors in African children . J Pediat 56:526-535, 1960.Crossref 2. O'Conor GT: Malignant lymphoma in African children: II. A pathological entity . Cancer 14:270-283, 1961.Crossref 3. Burkitt D: A sarcoma involving jaws in African children . Brit J Surg 46:218-223, 1958-1959.Crossref 4. Burkitt D, Davies JNP: Lymphoma syndrome in Uganda and tropical Africa . Med Press 245:367-369, 1961. 5. Burkitt D, O'Conor GT: Malignant lymphoma in African children: I. A clinical syndrome . Cancer 14:258-269, 1961.Crossref 6. Wright DH: The epidemiology of Burkitt's tumor . Cancer Res 27( (pt 1) ):2424-2438, 1967. 7. Templeton AC: Tumors of the eye and adnexa in Africans of Uganda . Cancer 20:1689-1698, 1967.Crossref 8. Zimmerman LE: The African malignant lymphoma . Arch Ophthal 63:838-839, 1962. 9. Lambert D: Les hematosarcomes de la face chez l'enfant en Afrique (maladie de Burkitt), thesis. Paris, 1964, pp 41-44. 10. Wright DH: Burkitt's tumor: A post-mortem study of 50 cases . Brit J Surg 51:245-251, 1964.Crossref 11. Quere MA, Camain R, Lambert D: Zur Pathologie der orbito-okularen Tumoren im Tropischen Africa . Klin Mbl Augenheilk 144:829-840, 1964. 12. Feman SS, et al: "Burkitt tumor" with intraocular involvement . Survey Ophthal 14:106-111, 1969. 13. Allen RA, Straatsma BR: Ocular involvement in leukemia and allied disorders . Arch Ophthal 66:490-508, 1961.Crossref 14. Hogan MJ, Zimmerman LE: Ophthalmic Pathology: An Atlas and Textbook , ed 2. Philadelphia, WB Saunders Co, 1962, pp 456-458. 15. Haddow AJ: Age incidence in Burkitt's lymphoma syndrome . E Afr Med J 41:1-6, 1964. 16. Simons PJ, Ross MGR: The isolation of herpes virus from Burkitt tumours . Europ J Cancer 1:135-136, 1965.Crossref 17. Griffin ER, Wright DH, Bell TM, et al: Demonstration of virus particles in biopsy material from cases of Burkitt's tumor . Europ J Cancer 2:353-358, 1966.Crossref 18. Wright DH, Bell TM, Williams MC: Burkitt's tumor: A review of clinical features, treatment, pathology, epidemiology, entomology and virology . E Afr Med J 44:51-61, 1967. 19. Harris RJC: A virus aetiology for Burkitt's tumor . Int J Cancer 2:559-561, 1967.Crossref 20. Burkitt DP: Etiology of Burkitt's lymphoma: An alternative hypothesis to a vectored virus . J Nat Cancer Inst 42:19-28, 1969. 21. O'Conor GT, Rappaport H, Smith EB: Childhood lymphoma resembling "Burkitt tumor" in the United States . Cancer 18:411-417, 1965.Crossref 22. Dorfman RF: Childhood lymphosarcoma in St. Louis, Missouri, clinically and histologically resembling Burkitt's tumor . Cancer 18:418-430, 1965.Crossref 23. Burkitt D: Burkitt's lymphoma outside the known endemic areas of Africa and New Guinea . Int J Cancer 2:562-565, 1967.Crossref 24. Fagundes LA, de Oliveira RM, Amaral R: Childhood lymphosarcoma in the state of Rio Grande do Sul, Brazil: Report of 20 cases histologically similar to Burkitt's tumor . Cancer 22:1283-1291, 1969.Crossref 25. Cohen MH, et al: Burkitt's tumor in the United States . Cancer 23:1259-1272, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Intraocular Involvement in Burkitt's Lymphoma

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References (26)

Publisher
American Medical Association
Copyright
Copyright © 1971 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1971.00990050297009
Publisher site
See Article on Publisher Site

Abstract

Abstract BURKITT'S lymphoma, which is a poorly differentiated lymphocytic lymphoma1,2 with unique epidemiologic features and a characteristic clinical and histologic pattern, is the most common malignant tumor among children in tropical Africa.3-6 It is also by far the most common of all orbital tumors, regardless of age, in Uganda.7 The tumor often arises in the superior portion of the maxilla and erodes the orbit to such an extent that exophthalmos, which may be extreme, is frequently the outstanding clinical feature and presenting symptom (Fig 1). Other clinical manifestations related to the infiltration of orbital soft tissues by the tumor may include chemosis and edema of the lid, tortuosity of retinal vessels, corneal anesthesia, exposure keratitis, corneal ulcers, and panophthalmitis.3-9 Recently we had an opportunity to study an eye that was enucleated from a patient with Burkitt's lymphoma, one in which there was massive invasion of the globe References 1. O'Conor GT, Davies JNP: Malignant tumors in African children . J Pediat 56:526-535, 1960.Crossref 2. O'Conor GT: Malignant lymphoma in African children: II. A pathological entity . Cancer 14:270-283, 1961.Crossref 3. Burkitt D: A sarcoma involving jaws in African children . Brit J Surg 46:218-223, 1958-1959.Crossref 4. Burkitt D, Davies JNP: Lymphoma syndrome in Uganda and tropical Africa . Med Press 245:367-369, 1961. 5. Burkitt D, O'Conor GT: Malignant lymphoma in African children: I. A clinical syndrome . Cancer 14:258-269, 1961.Crossref 6. Wright DH: The epidemiology of Burkitt's tumor . Cancer Res 27( (pt 1) ):2424-2438, 1967. 7. Templeton AC: Tumors of the eye and adnexa in Africans of Uganda . Cancer 20:1689-1698, 1967.Crossref 8. Zimmerman LE: The African malignant lymphoma . Arch Ophthal 63:838-839, 1962. 9. Lambert D: Les hematosarcomes de la face chez l'enfant en Afrique (maladie de Burkitt), thesis. Paris, 1964, pp 41-44. 10. Wright DH: Burkitt's tumor: A post-mortem study of 50 cases . Brit J Surg 51:245-251, 1964.Crossref 11. Quere MA, Camain R, Lambert D: Zur Pathologie der orbito-okularen Tumoren im Tropischen Africa . Klin Mbl Augenheilk 144:829-840, 1964. 12. Feman SS, et al: "Burkitt tumor" with intraocular involvement . Survey Ophthal 14:106-111, 1969. 13. Allen RA, Straatsma BR: Ocular involvement in leukemia and allied disorders . Arch Ophthal 66:490-508, 1961.Crossref 14. Hogan MJ, Zimmerman LE: Ophthalmic Pathology: An Atlas and Textbook , ed 2. Philadelphia, WB Saunders Co, 1962, pp 456-458. 15. Haddow AJ: Age incidence in Burkitt's lymphoma syndrome . E Afr Med J 41:1-6, 1964. 16. Simons PJ, Ross MGR: The isolation of herpes virus from Burkitt tumours . Europ J Cancer 1:135-136, 1965.Crossref 17. Griffin ER, Wright DH, Bell TM, et al: Demonstration of virus particles in biopsy material from cases of Burkitt's tumor . Europ J Cancer 2:353-358, 1966.Crossref 18. Wright DH, Bell TM, Williams MC: Burkitt's tumor: A review of clinical features, treatment, pathology, epidemiology, entomology and virology . E Afr Med J 44:51-61, 1967. 19. Harris RJC: A virus aetiology for Burkitt's tumor . Int J Cancer 2:559-561, 1967.Crossref 20. Burkitt DP: Etiology of Burkitt's lymphoma: An alternative hypothesis to a vectored virus . J Nat Cancer Inst 42:19-28, 1969. 21. O'Conor GT, Rappaport H, Smith EB: Childhood lymphoma resembling "Burkitt tumor" in the United States . Cancer 18:411-417, 1965.Crossref 22. Dorfman RF: Childhood lymphosarcoma in St. Louis, Missouri, clinically and histologically resembling Burkitt's tumor . Cancer 18:418-430, 1965.Crossref 23. Burkitt D: Burkitt's lymphoma outside the known endemic areas of Africa and New Guinea . Int J Cancer 2:562-565, 1967.Crossref 24. Fagundes LA, de Oliveira RM, Amaral R: Childhood lymphosarcoma in the state of Rio Grande do Sul, Brazil: Report of 20 cases histologically similar to Burkitt's tumor . Cancer 22:1283-1291, 1969.Crossref 25. Cohen MH, et al: Burkitt's tumor in the United States . Cancer 23:1259-1272, 1969.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1971

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