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Clinical Features of Superior Limbic Keratoconjunctivitis in Australia: A Probable Association With Thyrotoxicosis

Clinical Features of Superior Limbic Keratoconjunctivitis in Australia: A Probable Association... Abstract In Sydney, Australia, ten patients affected by superior limbic keratoconjunctivitis (SLKC) have been observed in one ophthalmic practice during a four-year period. Among the ten patients, three were found to be actively thyrotoxic, and two others had already undergone treatment for proven hyperthyroidism. Reference is made to a possible etiological contribution by the special anatomy of the upper conjunctival fornix and by secretions entering the conjunctival sac. The association with thyrotoxicosis revives the matter of an immunological (possibly auto-immune) origin for SLKC. A viral-induced mechanism has not been excluded. References 1. Theodore, F.H.: Superior Limbic Keratoconjunctivitis , Eye Ear Nose Throat Monthly 42:25-28 (Jan) 1963. 2. Thygeson, P., and Kimura, S.J.: Chronic Conjunctivitis , Trans Amer Acad Ophthal Otolaryng 67:494-517 ( (July-Aug) ) 1963. 3. Theodore, F.H.: Further Observations on Superior Limbic Keratoconjunctivitis , Trans Amer Acad Ophthal Otolaryng 71:341-351 ( (March-April) ) 1967. 4. Cher, I.: Epidemiology of SLKC, to be published. 5. Tenzel, R.R.: Comments on Findings of Elevated Protein-Bound Iodine in Superior Limbic Keratoconjunctivitis , letter to the editor, Arch Ophthal 79:508 ( (April) ) 1968.Crossref 6. Cher, I.: Comments on Dr. Tenzel's letter , letter to the editor, Arch Ophthal 80:416 ( (Sept) ) 1968.Crossref 7. Sutherland, A.L.: Lecture on SLKC, Trans Ophthal Soc New Zeal, to be published. 8. Jones, B.R., and Coop, H.V.: The Management of Keratoconjunctivitis Sicca , Trans Ophthal Soc UK 85:379-390, 1965. 9. Sapse, A.T., et al: Tears as Carriers of Antibodies , Arch Ophthal 77:526-529 ( (April) ) 1967.Crossref 10. McKenzie, J.M.: Humoral Factors in the Pathogenesis of Graves' Disease , Physiol Rev 48:252-310 ( (Jan) ) 1968. 11. Doniach, D., and Roitt, I.M.: " Auto-immune Thyroid Disease ," in Baldwin, R.W., and Humphrey, J.H. (eds.): Auto-immunity, Symposium of the International Academy of Pathology , Oxford: Blackwell Scientific Publications, 1965, pp 42-51. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Clinical Features of Superior Limbic Keratoconjunctivitis in Australia: A Probable Association With Thyrotoxicosis

Archives of Ophthalmology , Volume 82 (5) – Nov 1, 1969

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1969.00990020582002
Publisher site
See Article on Publisher Site

Abstract

Abstract In Sydney, Australia, ten patients affected by superior limbic keratoconjunctivitis (SLKC) have been observed in one ophthalmic practice during a four-year period. Among the ten patients, three were found to be actively thyrotoxic, and two others had already undergone treatment for proven hyperthyroidism. Reference is made to a possible etiological contribution by the special anatomy of the upper conjunctival fornix and by secretions entering the conjunctival sac. The association with thyrotoxicosis revives the matter of an immunological (possibly auto-immune) origin for SLKC. A viral-induced mechanism has not been excluded. References 1. Theodore, F.H.: Superior Limbic Keratoconjunctivitis , Eye Ear Nose Throat Monthly 42:25-28 (Jan) 1963. 2. Thygeson, P., and Kimura, S.J.: Chronic Conjunctivitis , Trans Amer Acad Ophthal Otolaryng 67:494-517 ( (July-Aug) ) 1963. 3. Theodore, F.H.: Further Observations on Superior Limbic Keratoconjunctivitis , Trans Amer Acad Ophthal Otolaryng 71:341-351 ( (March-April) ) 1967. 4. Cher, I.: Epidemiology of SLKC, to be published. 5. Tenzel, R.R.: Comments on Findings of Elevated Protein-Bound Iodine in Superior Limbic Keratoconjunctivitis , letter to the editor, Arch Ophthal 79:508 ( (April) ) 1968.Crossref 6. Cher, I.: Comments on Dr. Tenzel's letter , letter to the editor, Arch Ophthal 80:416 ( (Sept) ) 1968.Crossref 7. Sutherland, A.L.: Lecture on SLKC, Trans Ophthal Soc New Zeal, to be published. 8. Jones, B.R., and Coop, H.V.: The Management of Keratoconjunctivitis Sicca , Trans Ophthal Soc UK 85:379-390, 1965. 9. Sapse, A.T., et al: Tears as Carriers of Antibodies , Arch Ophthal 77:526-529 ( (April) ) 1967.Crossref 10. McKenzie, J.M.: Humoral Factors in the Pathogenesis of Graves' Disease , Physiol Rev 48:252-310 ( (Jan) ) 1968. 11. Doniach, D., and Roitt, I.M.: " Auto-immune Thyroid Disease ," in Baldwin, R.W., and Humphrey, J.H. (eds.): Auto-immunity, Symposium of the International Academy of Pathology , Oxford: Blackwell Scientific Publications, 1965, pp 42-51.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1969

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