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Prevention of the Ulcers of the Alkali-Burned Cornea: Preliminary Studies With Collagenase Inhibitors

Prevention of the Ulcers of the Alkali-Burned Cornea: Preliminary Studies With Collagenase... Abstract The corneal ulcers and perforations which inevitably occur with severe alkali burns have been prevented in six of eight eyes by the use of collagenase inhibitors. This indicates that collagenase is the cause of the ulcers and suggests an effective treatment for alkali burns and other ulcered states of the cornea where collagenase has been isolated. References 1. Slansky, H.H.; Freeman, M.I.; and Itoi, M.: Collagenolytic Activity in Bovine Corneal Epithelium , Arch Ophthal 80:496-498 ( (Oct) ) 1968.Crossref 2. Wünsch, E., and Heidrich, H.G.: Zur quantitativen Bestimmung der Kollagenase , Z Physiol Chem 333:149-151, 1963.Crossref 3. Brown, S.I.; Weller, C.A.; and Wassermann, H.E.: Collagenolytic Activity of Alkali Burned Corneas , Arch Ophthal 81:370-373 ( (March) ) 1969.Crossref 4. Gross, J., and Lapiere, C.M.: Collagenolytic Activity in Amphibian Tissues: A Tissue Culture Assay , Proc Nat Acad Sci 48:1014-1022 ( (June) ) 1962.Crossref 5. Evanston, J.M.; Jeffrey, J.J.; and Krane, S.M.: Human Collagenase: Identification and Characterization of an Enzyme From Rheumatoid Synovium in Culture , Science 158:499-502 ( (Oct 27) ) 1967.Crossref 6. Riley, W.B., and Peacock, E.E.: Identification, Distribution, and Significance of a Collagenolytic Enzyme in Human Tissues , Proc Soc Exp Biol Med 124:207-210 ( (Jan) ) 1967.Crossref 7. Hessburg, P.C.; Turant, J.P.; and Penn, W.P.: Corneal Infections in Experimental Animals: I. Introduction, Purpose, and Techniques , Amer J Ophthal 53:359-364 ( (Feb) ) 1962. 8. Grant, W.M.: New Treatment for Calcific Corneal Opacities , Arch Ophthal 48:681-685 ( (Dec) ) 1952.Crossref 9. Maurice, D.M.; Zauberman, H.; and Michaelson, I.C.: The Stimulus to Neovascularization in the Cornea , Exp Eye Res 5:168-184 ( (July) ) 1966.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Prevention of the Ulcers of the Alkali-Burned Cornea: Preliminary Studies With Collagenase Inhibitors

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1969.00990020097023
Publisher site
See Article on Publisher Site

Abstract

Abstract The corneal ulcers and perforations which inevitably occur with severe alkali burns have been prevented in six of eight eyes by the use of collagenase inhibitors. This indicates that collagenase is the cause of the ulcers and suggests an effective treatment for alkali burns and other ulcered states of the cornea where collagenase has been isolated. References 1. Slansky, H.H.; Freeman, M.I.; and Itoi, M.: Collagenolytic Activity in Bovine Corneal Epithelium , Arch Ophthal 80:496-498 ( (Oct) ) 1968.Crossref 2. Wünsch, E., and Heidrich, H.G.: Zur quantitativen Bestimmung der Kollagenase , Z Physiol Chem 333:149-151, 1963.Crossref 3. Brown, S.I.; Weller, C.A.; and Wassermann, H.E.: Collagenolytic Activity of Alkali Burned Corneas , Arch Ophthal 81:370-373 ( (March) ) 1969.Crossref 4. Gross, J., and Lapiere, C.M.: Collagenolytic Activity in Amphibian Tissues: A Tissue Culture Assay , Proc Nat Acad Sci 48:1014-1022 ( (June) ) 1962.Crossref 5. Evanston, J.M.; Jeffrey, J.J.; and Krane, S.M.: Human Collagenase: Identification and Characterization of an Enzyme From Rheumatoid Synovium in Culture , Science 158:499-502 ( (Oct 27) ) 1967.Crossref 6. Riley, W.B., and Peacock, E.E.: Identification, Distribution, and Significance of a Collagenolytic Enzyme in Human Tissues , Proc Soc Exp Biol Med 124:207-210 ( (Jan) ) 1967.Crossref 7. Hessburg, P.C.; Turant, J.P.; and Penn, W.P.: Corneal Infections in Experimental Animals: I. Introduction, Purpose, and Techniques , Amer J Ophthal 53:359-364 ( (Feb) ) 1962. 8. Grant, W.M.: New Treatment for Calcific Corneal Opacities , Arch Ophthal 48:681-685 ( (Dec) ) 1952.Crossref 9. Maurice, D.M.; Zauberman, H.; and Michaelson, I.C.: The Stimulus to Neovascularization in the Cornea , Exp Eye Res 5:168-184 ( (July) ) 1966.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Jul 1, 1969

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