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Combination Therapy in Retinoblastoma: A 15-Year Summary of Methods and Results

Combination Therapy in Retinoblastoma: A 15-Year Summary of Methods and Results Abstract Results of combination chemotherapy and radiation therapy of bilateral retinoblastoma in a group of 307 patients treated from 1953 to 1966 are reported. An overall "cure rate" of 55% with useful vision is being achieved as compared to 23% prior to 1953 with radiation only. In the patients with less advanced disease (groups 1, 2, and 3) results of "cure" ranged from 60% to 87%. The development of the present therapeutic regimen and the future trends in the program are outlined. References 1. Reese, A.B.; et al: The Treatment of Retinoblastoma by X-ray and Triethylene Melamine , Arch Ophthal 60:897-906 ( (Nov) ) 1958.Crossref 2. Hyman, G.A., et al: Chemotherapy of Retinoblastoma , Cancer 17:992-996 ( (Aug) ) 1964.Crossref 3. Hyman, G.A.; Ellsworth, R.M.; and Reese, A.B.: The Results of Combination Therapy of Retinoblastoma: A Nine-Year Study of 250 Cases , Acta Un Int Cancer 20:407-410 (No. (1-2) ) 1964. 4. Reese, A.B.; Merriam, G.R., Jr.; and Martin, H.E.: Treatment of Bilateral Retinoblastoma by Irradiation and Surgery: Report on 15-Year Results , Amer J Ophthal 32:175-190 ( (Feb) ) 1949. 5. Hyman, G.A., and Reese, A.B.: Combination Therapy of Retinoblastoma With Triethylene Melamine and Radiotherapy , JAMA 162:1368-1373 ( (Dec) ) 1956.Crossref 6. Gillette, R., and Bodenstein, D.: Specific Developmental Inhibitions Produced in Amphibian Embryos by a Nitrogen Mustard Compound , J Exp Zool 103:1-32 ( (Oct) ) 1946.Crossref 7. Kupfer, C.: Retinoblastoma Treated With Intravenous Nitrogen Mustard , Amer J Ophthal 36:1721-1723 ( (Dec) ) 1953. 8. Reese, A.B., et al: Treatment of Retinoblastoma by Radiation and Triethylene Melamine , Arch Ophthal 53:505-513 ( (April) ) 1955.Crossref 9. Fletcher, G.: Textbook of Radiotherapy , Philadelphia: Lea & Febiger, 1966, pp 312-318. 10. Kitchin, F.D., et al: Newer Genetic Findings in Retinoblastoma, abstract, Fourth annual meeting, American Society of Clinical Oncology, Atlantic City, NJ, April 10, 1968. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Combination Therapy in Retinoblastoma: A 15-Year Summary of Methods and Results

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References (13)

Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1968.00980050746012
Publisher site
See Article on Publisher Site

Abstract

Abstract Results of combination chemotherapy and radiation therapy of bilateral retinoblastoma in a group of 307 patients treated from 1953 to 1966 are reported. An overall "cure rate" of 55% with useful vision is being achieved as compared to 23% prior to 1953 with radiation only. In the patients with less advanced disease (groups 1, 2, and 3) results of "cure" ranged from 60% to 87%. The development of the present therapeutic regimen and the future trends in the program are outlined. References 1. Reese, A.B.; et al: The Treatment of Retinoblastoma by X-ray and Triethylene Melamine , Arch Ophthal 60:897-906 ( (Nov) ) 1958.Crossref 2. Hyman, G.A., et al: Chemotherapy of Retinoblastoma , Cancer 17:992-996 ( (Aug) ) 1964.Crossref 3. Hyman, G.A.; Ellsworth, R.M.; and Reese, A.B.: The Results of Combination Therapy of Retinoblastoma: A Nine-Year Study of 250 Cases , Acta Un Int Cancer 20:407-410 (No. (1-2) ) 1964. 4. Reese, A.B.; Merriam, G.R., Jr.; and Martin, H.E.: Treatment of Bilateral Retinoblastoma by Irradiation and Surgery: Report on 15-Year Results , Amer J Ophthal 32:175-190 ( (Feb) ) 1949. 5. Hyman, G.A., and Reese, A.B.: Combination Therapy of Retinoblastoma With Triethylene Melamine and Radiotherapy , JAMA 162:1368-1373 ( (Dec) ) 1956.Crossref 6. Gillette, R., and Bodenstein, D.: Specific Developmental Inhibitions Produced in Amphibian Embryos by a Nitrogen Mustard Compound , J Exp Zool 103:1-32 ( (Oct) ) 1946.Crossref 7. Kupfer, C.: Retinoblastoma Treated With Intravenous Nitrogen Mustard , Amer J Ophthal 36:1721-1723 ( (Dec) ) 1953. 8. Reese, A.B., et al: Treatment of Retinoblastoma by Radiation and Triethylene Melamine , Arch Ophthal 53:505-513 ( (April) ) 1955.Crossref 9. Fletcher, G.: Textbook of Radiotherapy , Philadelphia: Lea & Febiger, 1966, pp 312-318. 10. Kitchin, F.D., et al: Newer Genetic Findings in Retinoblastoma, abstract, Fourth annual meeting, American Society of Clinical Oncology, Atlantic City, NJ, April 10, 1968.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1968

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